Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"mitogen activated protein kinases"”.
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Investigations on the role of mitogen-activated protein kinases 11 and 17 in defense response of Arabidopsis thaliana
… findings revealed the involvement of the two mitogen-activated protein kinases MPK3 and MPK6 in the regulation of priming in Arabidopsis thaliana. Since the A. thaliana genome encodes 20 MPKs, I wondered, whether one or more of the other MPKs would be involved in priming. Bioinformatic …
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Design, Synthesis and Evaluation of Diphenylamines as MEK5 Inhibitors
The mitogen-activated protein kinases (MAPK) are a family of interrelated signal transduction kinases mediating intracellular responses to extracellular events. They are involved in mediating complex cellular events including, cell differentiation, cell proliferation, and cell death. Extracellular …
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Cartilage mechanobiology and transcriptional effects of combined mechanical compression and IGF-1 stimulation on bovine cartilage explants
… responses at the level of gene transcription, protein translation and post-translational modifications. Intracellular pathways including those involving integrin signaling, mitogen activated protein kinases (MAPKs), and release of intracellular calcium have been confirmed in several …
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DUSP5 Regulation of Inflammation and Insulin Signaling
… factor ? (TNF?). TNF? stimulates signaling of mitogen-activated protein kinases (MAPKs) within adipocytes (i.e. fat cells) and muscle cells that drive systemic inflammation and insulin resistance, leading to T2D. Until recently, most studies focused on the role of upstream kinases that link …
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UNDERSTANDING HOW MAP KINASES INFLUENCE ENDOTHELIAL NITRIC-OXIDE SYNTHASE ACTIVITY
<p>Mitogen activated protein kinases (MAPK) p38 and ERK have both been reported to bind endothelial nitric oxide synthase (eNOS) with submicromolar affinity via proposed interactions with a pentabasic non-canonical MAPK binding sequence in the autoinhibitory insertion of eNOS. The neuronal isoform, …
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Molecular Basis of HDL-Mediated Endothelial Cell Migration and Reendothelialization
… to circulating levels of high density lipoprotein (HDL) cholesterol. The atheroprotective nature of HDL is attributed mainly to its role in reverse cholesterol transport (RCT). However, recent reports of human and animal studies have suggested that the atheroprotective nature of HDL is not …
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Characterisation of the molecular mechanisms of EGFR signal transactivation in human cancer
… concentrations of GPCR agonists such as the mitogens LPA and S1P as well as therapeutically relevant concentrations of cannabinoids. Moreover, this study reveals ADAM17 and HB-EGF as the main effectors of this mechanism in most of the cancer cell lines investigated. However, depending on the …
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Ein molekularer Mechanismus des „Primings” in Arabidopsis thaliana
… requires accumulation of mRNA and inactive protein of mitogen-activated protein kinases (MPK) 3 and MPK6. Only upon challenge exposure to biotic or abiotic stress, MPK3/MPK6 enzymes were strongly activated in primed plants, resulting in enhanced defense gene expression and manifestation of …
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Nucleocytoplasmic Localization of MAPKs
Mitogen-activated protein kinases (MAPKs) comprise a family of protein-serine/threonine kinases, which participate in signal transduction pathways that control intracellular events. MAPKs are regulated by phosphorylation cascades, which are usually initiated by external stimuli including a variety …
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Protomyces Comparative Genomics and Modulation of Arabidopsis Immunity
… Arabidopsis immune responses with MAPKs (mitogen-activated protein kinases) activation and upregulation of salicylic acid signaling and camalexin biosynthesis marker genes. Additionally, indolic compounds produced by Protomyces species are able to activate plant auxin responses. The …
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Strukturen der Kraftübertragung im quergestreiften Muskel : Protein-Protein-Wechselwirkungen und Regulationsmechanismen
… dramatisch ändert, was mit einer veränderten Proteinzusammensetzung einhergeht. Immunfluoreszenz-Analysen von Skelettmuskelzellen verschiedener Differenzierungsstadien implizieren, dass die Signalwege, welche die Dynamik der Fokalkontakte in Nichtmuskelzellen bestimmen, nur für frühe Stadien …
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The effects of chrysin on osteoclastogenesis in RAW264.7 murine macrophages and bone metabolism in Sprague Dawley rats
… no significant changes in the phosphorylation of mitogen-activated protein kinases (MAPKs), specifically ERK, JNK, and P38, and NFκB signally pathways when treated to chrysin. Immunofluorescence investigation showed a significant inhibition in the amount of NFκB that translocated to the nucleus …
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Analysis of Cellular Transcriptomic Changes Induced by Merkel Cell Polyomavirus miRNA
… has thus far been on the oncogenic MCV early proteins, large tumour (LT) and small tumour (sT) antigens, there is a knowledge gap regarding MCV miRNA and its functional significance in MCV pathogenesis. Given the emerging importance of viral miRNAs in virus-host interaction and pathogenesis, …
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Substrate Interaction and Sub-Cellular Localization in Map Kinase Pathways
Protein kinase cascades control responses to extracellular cues by transmitting signals throughout the cell. Prominent among multifunctional enzymes in kinase cascades are the mitogen-activated protein kinases (MAPKs). Among the various MAPKs identified, the extracellular signal-regulated kinases, …
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Identification and Characterization of the Multifunctional Epigenetic Regulator CFP1 as an ERK1/2 Substrate
… covalent modifications to both histone proteins and DNA, the presence of transcription factors, and modification directly to the transcriptional machinery. Our lab is interested in the control of cellular processes by the mitogen activated protein kinases ERK1/2. In a yeast two-hybrid …
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The serotonin (5-HT) 2C receptor (5-HT2CR) and its downstream signaling components: Distinct adaptations in cortical circuits associated with cocaine exposure
… repeated cocaine administration: 1) 5 HT2CR protein expression and subcellular localization; 2) 5-HT2CR mRNA editing; 3) expression and subcellular localization of postsynaptic-density (PSD) protein-95 (PSD-95); and 4) phosphorylation of p44/p42-mitogen-activated protein kinases …
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Role of phosphatases in controlling arabidopsis mapk signalling cascades
… responses to various environmental conditions. Mitogen-activated protein kinases (MAPKs) constitute a highly conserved family of enzymes in eukaryotes, and in plants MAPK-based signal transduction modules regulate a large number of physiological processes, including responses to environmental …
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Nrf2 in metabolic related inflammation in the brain
… increases OS and promotes AD. Amyloid precursor protein (APP) is intimately linked with AD, with the Swedish mutation (<i>hAPP<sub>swe</sub></i>) used in numerous transgenic models. Furthermore, increasing importance has been placed on the suggested link between nutritional status and AD. To …
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Sulfate -Reducing Bacteria and Their Contribution to Intestinal Epithelial Disorders
… cell cycle traverse after 4h. This H2S-induced mitogenic response was mediated by mitogen-activated protein kinases (MAPK) ERK and p38, as revealed by kinase inhibition studies. Microarray analysis using an Affymetrix Rat Array(TM) confirmed that exposure to H2S (90 min) caused acute hypoxia, as …
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