Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"mitofusin"”.
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Mitofusin 2 Regulated Transport of Mitochondria is Necessary for Axonal Integrity
… type 2A, which is caused by mutations in the mitofusin 2: MFN2) gene. Utilizing an in vitro culture system, we find that CMT2A associated MFN2 mutants disrupt the transport of axonal mitochondria in DRG neurons. Though MFN2 has a previously defined role in facilitating mitochondrial fusion, we …
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Regulation of Mitochondrial Morphology by ERK1/2-Mediated Control of Mfn2 Stability
… 유지에 필수적이라는 사실이 차츰 밝혀지고 있다. 미토콘드리아의 형태는 Mitofusin 1(Mfn1), Mitofusin 2(Mfn2), Optic atrophy protein 1(Opa1), Dynamin related protein 1(Drp1), Fission protein 1(Fis1) 등의 미토콘드리아 형태조절 단백질(mitochondria-shaping protein)이 관여하는 미토콘드리아 융합-분열 기구(mitochondrial fusion-fission machinery)에 의해 정교하게 …
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Regulation and roles of nutrient-dependent mitochondrial fusion
… the regulators, Optic atrophy 1 (Opa1) and Mitofusin 1 (Mfn1).;Metabolomic analysis revealed both QLR-dependent and fusion-dependent changes in levels of metabolites involved in the urea cycle, Krebs cycle and REDOX balance. Findings in this project suggest putative mechanisms linking amino …
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IN VIVO AND IN VITRO EVALUATION OF THE COMBINATION OF RNA INTERFERING AND GENE THERAPY FOR TREATING MITOFUSIN2-RELATED DISEASES
Background: Mitofusin-2 (MFN2) is an outer mitochondrial membrane protein essential for mitochondrial networking in most cells. Autosomal dominant mutations in the MFN2 gene cause Charcot-Marie-Tooth type 2A disease (CMT2A), a severe and disabling sensory-motor neuropathy. Here, we propose a novel …
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Independent Functions Of Clueless In Differential Integrin Secretion And Mitochondrial Quality Control In Drosophila Muscle
… valosin-containing protein (VCP)-dependent Mitofusin/Marf proteasomal degradation to prevent damaged mitochondria from fusing with healthy ones, facilitating their clearance by autophagy (mitophagy). clu was found to genetically interact with PINK1 and parkin to regulate mitochondrial …
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The Role of FAM21 in the Regulation of Mitochondrial Dynamics
… accompanied by an increase of the fusion protein mitofusin 2 (Mfn2) and a reduction of the fission machinery components mitochondrial fission factor (MFF) and Dynamin-related protein 1 (Drp1). Mitochondrial elongation induced by FAM21 depletion was sensitive to fragmentation stimulus, suggesting a …
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REEP5-MFN1/2 tethering in ER-mitochondria crosstalk
… of several neurodegenerative diseases. Mitofusin 2 (MFN2), proposed to reside on the ER, is hypothesized to form heterotypic dimers with mitochondrial MFN1/2, enabling the transport of calcium and phosphatidylserine. However, its ER localization remains controversial, as super-resolution …
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Developmental Regulation of Mitochondrial Function in Ovine Fetal Skeletal Muscle
… of the adenine nucleotide transferase 1 and mitofusin 2 were all positively influenced by age, with the natural prepartum rise being prevented in the thyroidectomised fetuses. However, T3 infusion alone was insufficient to raise any of these factors prematurely. Cortisol infusion resulted in …
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Investigation into the mechanism of Nox2 NADPH oxidase-dependent signalling in doxorubicin cardiotoxicity
… (PGC1α), and the mitochondrial membrane protein, mitofusin 2 (Mfn2), which is known to be up- vi regulated by PGC1α, were selected as good candidates for further investigation. qPCR confirmed increased expression of Mfn2 mRNA in hearts from WT (1.3-fold) but not Nox2-/y DOX-treated animals, …
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Mechanism on Elongated Mitochondria Formation during Iorn Chelation-Induced Senescent Arrest
Enlarged or giant mitochondria have often been documented in aged tissues and several human disease harboring impaired function, although their role and the mechanism involved remain unclear. Recently, we observed progressive changes of mitochondrial morphology to highly elongated form during iron …