Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"mitochondrial transport"”.
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ROS regulation of axonal mitochondrial transport
… and survival in neurons, mitochondria are transported along axons, and accumulate in regions with high demand for their functions. Oxidative stress and abnormal mitochondrial axonal transport are associated with neurodegenerative disorders. However, we know little about the connection …
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Sideroflexins enable mitochondrial transport of polar neutral amino acids
… of metabolism necessitates regulated transport of metabolites across the inner mitochondrial membrane. While many proteins enabling mitochondrial membrane transport of metabolites are known, how some metabolites are transported is not known, and several mitochondrial amino acid …
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Microdevices for Isolating Single Axons for the Study of Axonal Transport in Dopaminergic Neurons
… isolation and study of axonal processes such as mitochondrial transport away from cell neuronal bodies. To achieve this goal, a PDMS microdevice comprised of two large chambers connected by a parallel array of microchannels successfully achieved separation of axons from the soma and allows …
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The role of mitochondrial transporters in human physiology and adverse drug effects
… prescribed medications often cause off-target mitochondrial dysfunction, but the underlying molecular mechanisms are largely unknown. Mitochondrial transport proteins form a significant class of potential off-targets that remain largely unexplored. The main aim of this thesis is to evaluate the …
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Mitofusin 2 Regulated Transport of Mitochondria is Necessary for Axonal Integrity
… that CMT2A associated MFN2 mutants disrupt the transport of axonal mitochondria in DRG neurons. Though MFN2 has a previously defined role in facilitating mitochondrial fusion, we propose a direct role for MFN2 in mediating transport based on its interaction with key components of the …
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Investigating the effect of amyotrophic lateral sclerosis-associated mutant vesicle-associated membrane protein B on axonal transport
… of neurons makes them dependent upon the proper transport of protein and organelle cargoes, especially through axons (axonal transport). Indeed, disruption to axonal transport is a very early, pathological event in ALS. A proline to serine substitution at position 56 in the vesicle-associated …
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The effects of hyperglycaemia on neuronal mitochondria
… functions. Through the processes of the electron transport chain (ETC) and oxidative phosphorylation, mitochondria convert pyruvate into adenosine triphosphate(ATP), a primary energy carrier. Mitochondria play an essential role in providing cellular energy by manufacturing ATP, buffering calcium …
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Investigating the Role of msBDNF – TrkB Signaling in the Maintenance of Mitochondrial Populations Through the BNIP3 Mitophagy Pathway
<p>Maintenance of mitochondrial transport and clearance at the pre- and post-synaptic terminal is an essential function of neuromuscular junctions to meet their high energy demands. Damaged or dysfunctional mitochondria can put stress on these synaptic junctions, ultimately leading to the …
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The role of Huntingtin in fast axonal transport
… the putative function of Htt in fast axonal transport, we characterized the co-localization of the Drosophila Htt homolog tagged with mRFP (dHtt-RFP), and the alterations in axonal transport kinetics associated with a dhtt null. We find that dHtt co-localizes with a subset of cargos including …
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IGF-1 signalling controls mitochondrial morphology and basal mitophagy in cancer
… elucidate the mechanisms by which IGF-1 promotes mitochondrial protection in cancer. Previously, we determined that the mitophagy receptor BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) is induced by IGF-1 to support mitochondrial turnover and protection. Here, we analysed a …
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Investigating putative pathogenic mechanisms within a family in which a chromosomal translocation confers risk of major mental illness
… in mitochondria may be due to the loss of the mitochondrial membrane potential, Δψm. The adoption of a co-staining protocol with antibodies for mitochondrial proteins enabled the visualisation of mitochondrial structure in all of the cells exogenously expressing CP60 and CP69. All of these …
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Mitochondrial ATP production and energy-buffering in the human pathogen Trypanosoma brucei
… Trypanosoma brucei. ATP is produced in the mitochondrial matrix from ADP and inorganic phosphate by substrate-level and oxidative phosphorylation. To maintain the cellular energy provision, ATP has to be exported from the mitochondrial matrix, and ADP and Pi imported from the cytosol. This …
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Functional characterisation of the human mitochondrial ATP-Mg/Pi carriers and their disease-causing variants
The mitochondrial ATP-Mg/Pi carriers (APCs) catalyses the exchange of adenine nucleotides for phosphate across the mitochondrial inner membrane, which is regulated by calcium. They are responsible for modulating the adenine nucleotide pool in the mitochondrial matrix, and therefore have a pivotal …
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Rationale Ansätze zur Prozessentwicklung eines Anti-EGF-IL2-Fusionsproteins mittels einer rekombinanten BHK-Zelllinie
… variations identified the influences of the mitochondrial transport systems on intracellular metabolic fluxes. The metabolic flux analysis allowed the balance of the fatty acid synthesis. The tool of metabolic flux analysis identified limitations within the fatty acid synthesis. Experiments …
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Use of Genetically Encoded Tools to Interrogate Mechanisms of Glutathione Homeostasis from Mitochondria to Mice
… Glutathione is thought to be critical for mitochondrial function, but it is not known how glutathione gets into mitochondria. Because of this, it has been very difficult to specifically deplete mitochondrial glutathione, resulting in circumstantial evidence that maintenance of glutathione …