Global ETD Search
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Showing 1 to 7 of 7 for “"mitochondrial ribosome"”.
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Biogenesis and Function of the Mitochondrial Ribosome
… into the biogenesis and function of the human mitochondrial ribosome. The mammalian mitochondrial ribosome (mitoribosome) is one of the largest ribonucleoprotein complexes in the cell, with the overall molecular mass of the fully assembled 55S monosome being ~2.7 MDa. It is indispensable for …
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Protein factors involved in the biogenesis of the mitochondrial ribosome
… phosphorylation (OxPhos) system, and the mitochondrial (mt-) rRNAs and tRNAs required for their translation. The maturation of the mitochondrial ribosome requires both mt-rRNAs to undergo post-transcriptional chemical modifications, folding of the rRNA and assembly of the protein …
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Structural studies of the mitochondrial ribosome and co-translational insertion of membrane proteins
… and yeast are encoded by both nuclear DNA and in mitochondrial DNA. As such the mitochondrion has retained its own translational system to include mitochondrial ribosomes (mitoribosome) to translate these proteins along with other proteins which is species dependent. The mitoribosome is also …
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The role of RNA modifications in mitochondrial translation
Mitochondrial gene expression entails multiple steps, one of which is translation, performed by the mitochondrial ribosome. Post-transcriptional RNA nucleotide modifications have been identified in mitochondrial (mt)-rRNAs. However, little is known about their role in terms of mitochondrial …
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Modeling Complex Neurological Disorders With Human Induced Pluripotent Stem Cells
… only the 22qDS gene MRPL40, a component of the mitochondrial ribosome, sufficiently replicated the mitochondria deficits. Another important gene in the 22q region, CLDN5 functions in tight junctions in the blood-brain barrier (BBB). We hypothesized that there would be deficits in HiPSC-derived …
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Genetic Engineering as a Tool to Investigate Mitochondrial Gene Expression
… polypeptides for the OXPHOS system, alongside mitochondrial rRNAs and tRNAs required for their expression. Gene expression in mitochondria is distinct from the bacterial and eukaryotic cytosolic counterparts, and many aspects of the processes of transcription and translation are not fully …
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The Evolution of Ribosome Assembly: Making Ribosomes in the Mitochondria
<p>Mitochondrial ribosomes (mitoribosomes) synthesize proteins encoded within the mitochondrial genome that are assembled into oxidative phosphorylation complexes. As such, the biogenesis of mitoribosomes is essential for ATP production and cellular metabolism. Despite significant progress in …