Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 117 for “"mitochondrial respiration"”.
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Cardiac mitochondrial respiration in two rodent models of obesity
… diabetes, increased FFA supply decreases cardiac mitochondrial bioenergetic capacity. Furthermore, we also hypothesized that females possess innate cardioprotective programs that will result in enhanced bioenergetic capacity compared to males. We examined our hypothesis employing two rodent models …
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Regulation of mitochondrial respiration by LDHB suppression in hepatoma cell lines
Increase in aerobic glycolysis and mitochondrial dysfunction are important metabolic features in human cancers. However, it still remains unclear how these phenomena are developed during tumorigenesis. To maintain aerobic glycolysis, continuous generation of NAD+ by lactate dehydrogenase (LDH) with …
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Lipid metabolism and mitochondrial respiration in adipose tissue and liver during obesity
… function. It has been proposed that changes in mitochondrial respiratory function are associated with WAT expansion and hepatic steatosis, but whether this is associated with alterations in the tissue lipid composition remains unclear. The impact of age and sex on lipid profile and mitochondrial …
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Modulation of Mitochondrial Respiration and Metabolic Signalling in Skeletal Muscle by Caveolin-3
… the muscle specific Cav3 isoform may make to mitochondrial respiratory capacity and to determine whether Cav3 has a role to play in the nutrient-dependent activation of mTORC1, an event that has been shown to be closely associated with the lysosome. Herein, I establish that Cav3 localises to …
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The Effect of Allopurinol and Inosine Administration on Xanthine Oxidoreductase Gene Expression, Mitochondrial Respiration, and Inflammation in Broiler Chickens
… BW). The purpose of this study was to assess mitochondrial function in broiler chickens in response to potential oxidative stress generated from the administration of allopurinol. Mitochondria were freshly isolated from liver tissue and assessed for State III and State IV respiration using …
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A License to Kill: Understanding Natural Killer Cell Licensing to Fight Cancer
… are highly glycolytic, and use glycolysis and mitochondrial respiration for cytolysis of leukemia targets, whereas unlicensed NK cells are dependent on mitochondrial respiration. We determined the metabolic pathways that are necessary for licensed and unlicensed NK cells to elicit a cytolytic …
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Control of Cellular Redox State and Biomass Synthesis
… rates. We uncover that some cancer cells elevate mitochondrial respiration and increase the NAD+/NADH ratio following serine withdrawal while others do not. Increasing mitochondrial respiration is sufficient to elevate the NAD+/NADH ratio and improve serine synthesis and proliferation in serine …
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Design and Synthesis of 8-Trifluoromethyl-Substituted Heterocyclic Small Molecule Mitochondrial Uncouplers for the Treatment of Metabolic Diseases
… converted into energy through a process called mitochondrial respiration. Through this process, mitochondria provide over 90% of cellular energy. However, during inflammatory events, mitochondrial respiration is less efficacious and could cause or progress diseases such as obesity, type 2 …
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The oxidative metabolism of malate plus pyruvate, and a-ketoglutarate by vitamin E-deficient rat liver mitochondria
… significant differences were seen among state 4 respiration with α-ketoglutarate, state 4 respiration(combined data with endogenous, pyruvate plus malate and α-ketoglutarate), state 3 endogenous respiration, and state 3 respiration (combined data with endogenous, pyruvate plus malate, and …
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Hibernation is super complex: dynamics of electron transport system supercomplexes
… complexes form supercomplexes (SCs) within mitochondrial membranes, perhaps increasing respiratory capacity or reducing reactive oxygen species production. My project aimed to determine the abundance, composition, and stability of SCs in a hibernator. Hibernators have dynamic metabolisms …
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The Role of Glutamine and Mevalonate Pathway In Affecting The Stemness and Viability of Glioblastoma Stem Cells
… the oxygen consumption as an indication of mitochondrial respiration cultured in serum-free medium in comparison with that incubated in medium containing FBS. We found that GSC11 and GSC23 stem cells exhibited low mitochondrial respiration when cultured in stem cell medium. Upon exposure to …
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Influence of Oxygenated Perfluorocarbon (oxyPFC) on survival and free radical production of Ischemic Cardiomyocytes
… in this study was the effect of oxyPFC on mitochondrial respiration in a hypoxic state of the cardiomyocyte, and the second was to find out which role oxygen free radicals, especially superoxide, play after administration of oxyPFC. Several cellular biological methods were used to analyse …
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The Effect of Alhagi maurorum Medik on Mitochondrial Function
Mitochondrial bioenergetics are crucial for the optimal activity of the cell and are emerging therapeutic targets for the treatment of several metabolic syndromes and cancer. Alhagi maurorum plant is traditionally used in several clinical conditions due to its potential anti-inflammatory, …
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Effect of aflatoxin on mitochondrial transcription and translation
… RNase. Aflatoxin B₁ inhibited in vitro mitochondrial ³H-UTP incorporation only 12% at high concentrations (0.4 mM or 130 nmol/mg protein). On the other hand, 25% inhibition was observed with mitochondria isolated 4 hr after animals had been treated with aflatoxin B₁ (5.3 mg/kg body …
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Yeast Ataxin-2, A Protein with Many Friends: Identification of a Novel Role for Pbp1 in Mitochondrial Biogenesis
… a respiratory environment forces the cell to use mitochondrial respiration, and as a result, mitochondrial biogenesis is induced. Puf3 functions as a glucose sensor in yeast to support mitochondrial biogenesis in respiratory conditions. It facilitates a rapid stabilization of its target …
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The Role of MCL-1 in the Heart: Gateway from Life to Death
… abnormal mitochondria ultrastructure, defective mitochondrial respiration, and impaired autophagy. Genetic ablation of both pro-apoptotic effectors (Bax and Bak) could largely rescue the lethality and impaired cardiac function induced by Mcl-1 deletion. However, Mcl-1-, Bax-, and Bak-deficient …
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Characterization of molecular and functional changes regulating hypobaric hypoxia-induced right ventricular hypertrophy
… admnistration elicited direct effects on mitochondrial respiratory function and cardiac contractility. The data show that Wy-14,643 treatment attenuated mitochondrial respiration (state 3 respiration and rate of ADP phosphorylation) in the RV while promoting uncoupling of mitochondrial …
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The effect of beta-oxidation or TCA cycle inhibition on mitochondrial function and the sensitivity of high resolution respiratory detection
… in HRR assessment to detect changes in mitochondrial respiration and dysfunction induced by the inhibition of either β-oxidation or the TCA cycle in C2C12 myotubes. Furthermore, we assessed MCAD, citrate synthase and aconitase enzyme activities when β-oxidation or TCA cycle was inhibited …
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Skeletal muscle weakness and mitochondrial dysfunction in the osteogenesis imperfecta murine (oim) model
… weakness primarily through the investigation of mitochondrial health in a mouse modeling a severe human type III OI (oim/oim), as mitochondria are important regulators of energy metabolism and overall cell health. We hypothesized that oim/oim mice, exhibiting severe skeletal muscle weakness would …
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