Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 20 for “"mitochondrial quality"”.
-
Analysis of PINK1/Parkin-related mitochondrial quality control in Drosophila
… homeostatic processes operate to maintain mitochondrial integrity; however, terminally damaged organelles are degraded through the process of targeted mitochondrial autophagy (mitophagy) to prevent potentially catastrophic consequences. Such homeostatic mechanisms are particularly important …
-
Impacts of microRNAs on Skeletal Muscle Protein Synthesis and Mitochondrial Quality
… contents of COX-IV, a surrogate measure of mitochondrial content, were higher in both miR-1 (~100%) and -133b (~45%) overexpressed cells. Additionally, any change in mitochondrial content was separate from TFAM or PGC-1α protein as neither was changed by miR-1 or -133 overexpression. …
-
The Regulation of Lipid Metabolism and Mitochondrial Quality Control in Health and Disease
… as the interaction between lipid metabolism and mitochondrial health. </p><p>To study the overlap between obesity and neurodegeneration, we investigated two pathways that regulate both. First, we find that loss of cytoplasmic deacetylase HDAC6 leads to aberrant accumulation of lipid in vitro and …
-
Be Eaten to Stay Healthy: Elucidating the Mechanisms of Mitochondrial Quality Control by Mitophagy
… particularly susceptible to the consequences of mitochondrial damage as they have high energy needs and are post-mitotic. The clearance of damaged mitochondria by autophagy, or mitophagy, has emerged as an important quality control mechanism. The Parkinson's disease related proteins phosphatase …
-
Mitochondrial Quality Control Adaptations Support Malignant Progression of Serous Ovarian Cancer Cells and Spheroids
… migration, and invasion through modulation of quality control, mitochondrial dynamics, mitophagy, and mitobiogenesis. We have shown that aggregation of cancer cells supports increased mitochondrial fragmentation localized to the hypoxic core of our spheroid models. Further, aggregation supports …
-
Independent Functions Of Clueless In Differential Integrin Secretion And Mitochondrial Quality Control In Drosophila Muscle
… are known for their role in the prevention of mitochondrial clustering. Here, we uncover its independent roles in the delivery of integrin subunits and the regulation of mitochondrial quality control (MQC) in muscles. In clu mutants, αPS2, but not βPS, integrin abnormally accumulates in the …
-
THE ORGANIZATION OF MITOCHONDRIAL QUALITY CONTROL AND LIFE CYCLE IN THE NERVOUS SYSTEM IN VIVO IN THE ABSENCE OF PINK1
Maintenance of healthy mitochondria is crucial in cells, such as neurons, with high
-
Mitochondrial inheritance and cell cycle regulation in Saccharomyces cerevisiae
… cytokinesis when there are severe defects in mitochondrial inheritance. An established checkpoint signaling pathway, the mitotic exit network (MEN), participates in this process. Here, we describe mitochondrial motility during inheritance in budding yeast, emerging evidence for mitochondrial …
-
Skeletal muscle autophagy and mitophagy in response to high-fat feeding and endurance training
… are commonly associated with an accumulation of mitochondrial dysfunction, which is speculated to contribute toward insulin resistance. High-fat diets reduce human skeletal muscle insulin sensitivity and mitochondrial function. Conversely, endurance training increases insulin sensitivity and …
-
The Role of ATF4 in Mediating Skeletal Muscle Function in Response to Acute Contractile Activity
… Integrated Stress Response (ISR) is a newfound mitochondrial quality control stress mechanism that is activated in the face of intraorganellar stress and is capable of transducing various transcriptional responses in a manner dependent on the activating transcription factor 4 (ATF4). …
-
Axonal transport and life cycle of mitochondria in Parkinson's disease model
… Parkinson’s disease, has been implicated in mitochondrial dynamics and removal. However, it is not clear how Parkin plays a role in mitochondrial turnover in vivo, and whether the mature neurons possess a compartmentalized Parkin-dependent mitochondrial life cycle. Using the live …
-
Aerobic Exercise-Mediated Prevention Against Glucocorticoid Myopathy in Aged Skeletal Muscle
… contents of protein related to calcium handling, mitochondrial quality control, and glucocorticoid receptor in muscle. These findings define several important sexually dimorphic changes to aged skeletal muscle physiology in response to glucocorticoid treatment and define the capacity of short-term …
-
DYSREGULATION of PROTEIN QUALITY CONTROL IMPAIRS FUNCTION of PRIMARY CARDIOMYOCYTES
… of reactive oxygen species (ROS), by-products of mitochondrial respiration, within dysfunctional mitochondria results in the activation of cardiac cell death pathways and has been associated with heart failure development. Therefore, maintaining mitochondrial homeostasis as a balance between …
-
EXPLORING MITOCHONDRIAL AND REDOX VULNERABILITY IN FRIEDREICH'S ATAXIA USING GOLD NANOCLUSTERS IN HUMAN CELLULAR MODELS
… impaired iron–sulfur cluster biogenesis, mitochondrial dysfunction, and chronic oxidative stress. Despite significant advances in the understanding of FRDA pathophysiology, the identification of reliable cellular models for mechanistic studies and preclinical screening remains a major …
-
Mitochondrial Inheritance and Function in the Lifespan Control of Budding Yeast
… conserved protein phosphatase, Ptc1p, regulates mitochondrial anchorage by dephosphorylation of Mmr1p. Mitochondrial fitness decreases as a function of age, yet retention of less fit mitochondria occurs to the same extent in young and older cells. Disruption of mitochondrial anchorage at the bud …
-
Age-Related Hamster Mitochondrial Changes and Oocyte Changes Following Autologous Platelet Mitochondrial Microinjection
… study's objective was to verify age-related mitochondrial changes in oocytes from old hamsters compared with those from young hamsters. We used autologous platelet mitochondrial microinjection to improve the mitochondrial quality and quantity of aged oocytes to improve their pregnancy …
-
Mitochondrial mRNA Translation is Required for Maintenance of Oxidative Capacity
… forms of cardiomyopathy and to determine if mitochondrial mRNA translation initiation factor (mtIF2) is necessary to maintain oxidative capacity in cardiomyocytes. Methods Using a combination of animal and cell culture experiments, we first analyzed the oxidative detriments of the myocardium …
-
MECHANISM OF PINK1-MEDIATED UBIQUITIN PHOSPHORYLATION
… (PTEN-induced Putative Kinase 1) is crucial for mitochondrial quality control and loss or mutation of PINK1 can lead to autosomal recessive juvenile parkinsonism (AR-JP). PINK1 is an unusual kinase, as it is characterised by three unique insertions in its kinase N lobe and a C-terminal region …
-
Determination of the Composition and Architecture of the Mitochondrial Ubiquitome in PINK1/Parkin Mitophagy
… with multiple lines of evidence suggesting that mitochondrial dysfunction may underlie the etiology of the disease. The kinase PINK1, and the ubiquitin (Ub) E3 ligase Parkin, function in a pathway to maintain mitochondrial quality control through the engulfment of mitochondria by the autophagy …
-
Role of PARK2Gene in Maintenance of Pancreatic Beta Cell Functions
… for impaired mitochondria, plays a key role in mitochondrial quality control. Defects in mitophagy that contribute to causing mitochondrial dysfunction have been recently suggested to be involved in the pathogenesis of T2D as well as in neurodegenerative diseases. By performing a candidate-gene …