Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"mitochondrial physiology"”.
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Unraveling the interaction between hormones and incubation temperature on lizard cognition
… can shape cognitive abilities by altering brain physiology or function. Here, I investigated how prenatal thermal environment and corticosterone (CORT) - a key stress hormone in reptiles - affects cognitive development in two species of skinks: the delicate skink (Lampropholis delicata), and the …
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Unraveling the interaction between hormones and incubation temperature on lizard cognition
… can shape cognitive abilities by altering brain physiology or function. Here, I investigated how prenatal thermal environment and corticosterone (CORT) - a key stress hormone in reptiles - affects cognitive development in two species of skinks: the delicate skink (Lampropholis delicata), and the …
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Metabolic flux analysis and population heterogeneity in mammalian cell culture
… used to develop relations between mammalian cell physiology and specific culture environments and to formulate strategies for increasing cell culture performance. Mitochondrial characteristics associated with respiration, membrane potential, and apoptosis along with physiological state …
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Revealing a Non-canonical Role of Anti-apoptotic MCL-1 in Early Embryonic Development
… an unrecognized role of MCL-1 in promoting mitochondrial physiology, which is independent of its classical anti-apoptotic function and requires being imported into the mitochondrial matrix. In order to understand the role of MCL-1 in early embryonic development, we used CRISPR-Cas9 to target …
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Interplay of Iron and Hydrogen Sulfide in Pathophysiology of Vascular Damage
… through a series of studies spanning molecular, mitochondrial, cellular, and whole-animal levels. The molecular basis of H₂S–iron interactions in vascular smooth muscle cells was defined, demonstrating that endogenous H₂S upregulates ferritin expression, balances apoptosis–autophagy signaling, …
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Disruption of mitochondrial redox homeostasis as a cellular signal.
… to disentangle the overlapping effects of mitochondrial ROS signalling compared to a redox signal stemming from disruption of mitochondrial thiol homeostasis. Furthermore, it is important to distinguish between disturbing the cytosolic and mitochondrial protein antioxidant systems. I …
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A Role for the HSV Tegument Protein pUL16 in Modulating Cellular Energy Metabolism during HSV-2 Infection
… biotinylation experiments identified both mitochondrial-associated membrane and mitochondrial matrix components in proximity to HSV-2 pUL16 during virus infection. While the interaction between pUL16 and host cell mitochondria has been well-established, the implications have yet to be …
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Chronic low-level Pb exposure during development alters proteins involved in energy metabolism in auditory neurons of the brainstem
… is an ion channel involved in the regulation of mitochondrial physiology and is a critical component in controlling mitochondrial energy production. No studies to date have investigated the effect of Pb on VDAC, therefore the current series of studies examines the interactions between Pb and …
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Chronic low-level Pb exposure during development alters proteins involved in energy metabolism in auditory neurons of the brainstem
… is an ion channel involved in the regulation of mitochondrial physiology and is a critical component in controlling mitochondrial energy production. No studies to date have investigated the effect of Pb on VDAC, therefore the current series of studies examines the interactions between Pb and …
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Electron cryomicroscopy structures of respiratory supercomplexes from alphaproteobacteria suggest mechanisms to enhance catalysis and to prevent deactivation of respiratory complex I
… their selective advantage is. While the role of mitochondrial CIII-CIV-type supercomplexes in the context of enhancing catalysis is being delineated, the function of respiratory supercomplexes, particularly at the level of complexes I and III, is unresolved. Moreover, the structures of …
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Identification and functional characterisation of different inner mitochondrial membrane supercomplexes
… is densely packed with proteins necessary for mitochondrial activity, including oxidative phosphorylation (OXPHOS) complexes and transporters. Mitochondrial respiratory chain (MRC) complexes, which generate ATP by OXPHOS, associate in higher-order assemblies, known as supercomplexes (SC), that …