Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"mitochondrial morphology"”.
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IGF-1 signalling controls mitochondrial morphology and basal mitophagy in cancer
… elucidate the mechanisms by which IGF-1 promotes mitochondrial protection in cancer. Previously, we determined that the mitophagy receptor BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) is induced by IGF-1 to support mitochondrial turnover and protection. Here, we analysed a …
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Regulation of Mitochondrial Morphology by ERK1/2-Mediated Control of Mfn2 Stability
… 세포의 운명 결정과 직결된 다양한 생명활동에 관여하고 있으며, 미토콘드리아의 형태(morphology) 조절이 세포의 항상성(homeostasis) 유지에 필수적이라는 사실이 차츰 밝혀지고 있다. 미토콘드리아의 형태는 Mitofusin 1(Mfn1), Mitofusin 2(Mfn2), Optic atrophy protein 1(Opa1), Dynamin related protein 1(Drp1), Fission protein 1(Fis1) 등의 미토콘드리아 형태조절 단백질(mitochondria-shaping …
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Effects of loigomycin, F0/F1 ATP-synthase inhibitor on mitochondrial morphology and dynamics
Mitochondrial fission has recently been well-recognized as a factor involved in apoptosis although its role and the underlying mechanism remains unclear. Recently, we monitored the effects of mitochondrial respiratory inhibitors [rotenone, TTFA (2-thenoyltrifluoro-acetone), antimycin A, and …
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MITOCHONDRIA FACILITATE VASCULAR INFLAMMATION: THE ROLE OF CANONICAL INFLAMMATORY SIGNALING IN THE REGULATION OF MITOCHONDRIAL MORPHOLOGY
… inflammatory based diseases are associated with mitochondrial dysfunction and morphological alterations, the direct mechanisms tying the mitochondria to canonical NF-κB signaling remain elusive. Using pharmacological and genetic approaches, we show inflammatory-mediated mitochondrial fission, …
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Insights into the Functional Link between MtHsp40:MtHsp70 Network and Mitochondrial Homeostasis
Mitochondrial apoptosis, morphology and function can be modulated by the activity of mitochondrial chaperones including mtHsp40 and mtHsp70. We found that both overexpression and depletion of mtHsp40 reversibly changed mitochondrial morphology from tubular network to fragmented puncta, in a process …
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The Role of FAM21 in the Regulation of Mitochondrial Dynamics
Mitochondrial network remodelling is crucial for cells to adapt and respond to metabolic cues and stress signals. Processes collectively known as mitochondrial dynamics, including ongoing cycles of fusion and fission, regulate mitochondrial shape, size and distribution, governing mitochondrial …
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Mitochondrial dynamics in the radiation response of cancer cells
… that determine the response of cells to damage. Mitochondrial fission and fusion are associated with cell cycle regulation, apoptosis, cellular bioenergetics and redox status, which contribute to cellular homeostasis and damage response. The study aimed to describe and correlate cancer cell …
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The Effect of Alhagi maurorum Medik on Mitochondrial Function
Mitochondrial bioenergetics are crucial for the optimal activity of the cell and are emerging therapeutic targets for the treatment of several metabolic syndromes and cancer. Alhagi maurorum plant is traditionally used in several clinical conditions due to its potential anti-inflammatory, …
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Characterisation of new factors regulating mitochondrial dynamics and cellular metabolism
… Recently, the uncharacterised protein, mitochondrial fission regulator 1 like protein (MTFR1L), has been identified as a substrate for the metabolic kinase adenosine monophosphate kinase (AMPK). Phylogenetically, MTFR1L has been categorised within the mitochondrial fission regulator 1 …
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Insights Into Mitochondrial Genetic and Morphologic Dynamics Gained by Stochastic Simulation
… involved are not completely understood. The mitochondrial genetic bottleneck has puzzled biologists for a long time. Approximate models of genetic bottleneck proposed in the literature do not accurately model underlying biology. Recent studies indicate mitochondrial morphology changes during …
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Nuclear Encoded Proteins Important in Mitochondrial Genome Stability
… mutations. In addition, loss of Clu1p alters mitochondrial morphology.
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Axonal transport and life cycle of mitochondria in Parkinson's disease model
… Parkinson’s disease, has been implicated in mitochondrial dynamics and removal. However, it is not clear how Parkin plays a role in mitochondrial turnover in vivo, and whether the mature neurons possess a compartmentalized Parkin-dependent mitochondrial life cycle. Using the live …
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Identification of cellular functions of cardiolipin as physiological modifiers of barth syndrome
… is an anionic phospholipid synthesized in the mitochondrial inner membrane. Perturbation of CL metabolism leads to Barth syndrome (BTHS), a life threatening genetic disorder. I utilized genetic, biochemical and cell biological approaches in yeast to elucidate the cellular functions of CL. …
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Role of trans-Golgi network vesicles in mitochondrial fusion
… of membrane fusion and fission are hallmarks of mitochondrial behaviour. In recent decades, the study of mitochondrial dynamics has come to the forefront of cell biology due to a growing recognition that the ever-changing shape of mitochondria has a basic impact on their function, affecting a …
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Burn Serum Stimulates Mitochondrial Fission in C2C12 Myoblasts
… with a hypercatabolic status. Impairment of mitochondrial function has been observed in the muscle of burn patient's. OBJECTIVE: We hypothesize that muscle atrophy due to burn injur y is associated with an alteration in mitochondrial dynamics. This study was designed to investigate changes in …
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Role of Mitochondrial Dynamics and Autophagy in Removal of Helix-Distorting Mitochondrial DNA Damage
… to translate these proteins. Over 300 pathogenic mitochondrial DNA (mtDNA) mutations have been shown to cause a number of mitochondrial diseases emphasizing the importance of mtDNA maintenance and integrity to human health. Additionally, mitochondrial dysfunction and mtDNA instability are linked …
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Autism Spectrum Disorder and Mitochondrial Dysfunction: The Role of Mitochondrial Dynamics
… disorder (ASD). Our research group reported that mitochondrial dysfunction was associated with ASD in South African children diagnosed with ASD using differential methylation and metabolomics studies. Propionyl-CoA Carboxylase Subunit Beta (PCCB) was differentially methylated in our cohort ASD …
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Characterization of a Novel Fis1 Interactor Required for Peripheral Distribution of the Mitochondrion of Toxoplasma Gondii
… results in a complete disruption of the normal mitochondrial morphology. In intracellular LMF1 knockout parasites, the mitochondrial lasso shape is disrupted‚ and instead it is collapsed as normally only seen in extracellular parasites. Additionally, proper mitochondrial segregation is …
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Mechanism on Elongated Mitochondria Formation during Iorn Chelation-Induced Senescent Arrest
… Recently, we observed progressive changes of mitochondrial morphology to highly elongated form during iron chelation-induced senescence-associated growth arrest of Chang cells. Interestingly, addition of H₂O₂ (200uM) was enough to induce mitochondrial elongation with cellular senescent …
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Development of Quantitative Optical Coherence Tomography Methods for Cell Death Detection
… rate of the speckle intensities were linked to mitochondrial morphology. Finally, preliminary studies using mouse tumour models demonstrated the feasibility of using these parameters to detect cell death in vivo.
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