Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 68 for “"mitochondrial metabolism"”.
-
Mitochondrial metabolism and CNS myelination
… of white matter involvement in patients with mitochondrial disorders has been increasing. Given the high-energy demand nature of the brain, this tissue is preferentially affected by energy deficiency caused by mitochondrial dysfunctions. After birth, partial oxygen pressures rise in the …
-
Mitochondrial Metabolism of Human Kidney Cancers
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
-
Mathematical modelling of mammalian mitochondrial metabolism
… variables in the reaction equations. In heart, mitochondrial energy metabolism involving utilization of dietary carbo-hydrates and fats bears a crucial importance for the normal physiological function of the cardiac muscle. The mammalian liver-specific tricarboxylic acid cycle (TCA) model …
-
Novel mitochondrial metabolism in excavate protists
… a host for heterologous expression, I tested the mitochondrial candidature of several of these N. gruberi novel proteins associated with anaerobic metabolism. Since the Heterolobosea are sister to the Euglenozoa, evidence for the expression and localisation of N. gruberi proteins in T. brucei is a …
-
Mitochondrial Metabolism in Ischaemia Reperfusion Injury
… been identified as a new therapeutic target. The mitochondrial metabolite succinate accumulates during ischaemia, before being rapidly oxidised by SDH upon reperfusion, producing reactive oxygen species (ROS), and leading to oxidative damage and cell death. The aim of this thesis was to determine …
-
Mitochondrial metabolism in cancer transformation and progression
… undergo a multifaceted rewiring of cellular metabolism to support their biosynthetic needs. Although the major determinants of this metabolic transformation have been elucidated, their broad biological implications and clinical relevance are unclear. In this study, I systematically analysed …
-
Mitochondrial Metabolism Elucidated by Rapid Fractionation from Tissue
… hubs, with many diseases found to have altered metabolism and mitochondrial dysfunction, such as ischaemia-reperfusion injury. A detailed understanding of the metabolic changes in different cellular pools would aid diagnosis and treatment. However, the current methods of mitochondrial isolation …
-
Coupling mechanisms of insulin secretion - roles of mitochondrial metabolism and cAMP.
… secretion. Both these findings prove that mitochondrial metabolism is important for insulin secretion, and points to the involvement of pyruvate cycling. We have also showed that PKA signaling is stimulated by glucose, and that inhibition of PKA decreases glucose-stimulated insulin …
-
VDAC and SOD1: two major players in mitochondrial metabolism and in ALS
… is a pore-forming protein located in the outer mitochondrial membrane, where it is suspected to play a key role in metabolism regulation, as the interface between mitochondria and cytosol, and in apoptosis regulation. In the small family of VDAC proteins, composed of three isoforms in chordates, …
-
TARGETING TYPE-I PRMTS RESTORES PLATINUM SENSITIVITY IN OVARIAN CARCINOMA THROUGH MITOCHONDRIAL METABOLISM
… post-translational modifications, and mitochondrial metabolic plasticity underpinning chemoresistance in EOC. We present an integrative multi-omics analysis of carboplatin-resistant A2780 ovarian cancer cells (A2780R) developed via stepwise drug adaptation, revealing pronounced …
-
The Role of Schwann Cell Mitochondrial Metabolism in Schwann Cell Biology and Axonal Survival
Mitochondrial dysfunction has emerged as a common cause of peripheral neuropathies. While the role of neuronal and axonal mitochondria in peripheral nerve disease is well appreciated, whether Schwann cell: SC) mitochondrial deficits contribute to peripheral neuropathies is unclear. Greater insight …
-
Reactive oxygen species and mitochondrial metabolism in acute myocardial ischaemia reperfusion injury: measurement and modulation
… (AMI), where their production is driven by the metabolism of the citric acid cyclic intermediate succinate that accumulates during ischaemia. This is a major driver of damage upon reperfusion of ischaemic tissue. ROS are however increasingly understood to not only have negative effects, but also …
-
Effect of selected drugs on mitochondrial metabolism in an in vitro model of human skeletal muscle
… Increasing number of reports reflect that mitochondrial dysfunction can be induced by some of the commonly used drugs and can play a key role in the development of their adverse effects. One of these drugs is a phenol derivative propofol. Propofol is an intravenous, fast and short-acting …
-
THE PROSURVIVAL ACTIVITIES OF APOPTOSIS-INDUCING FACTOR CONVERGE UPON THE REGULATION OF MITOCHONDRIAL METABOLISM, A NOVEL CELL DEATH PATHWAY, AND THE PROGRESSION OF PROSTATE CANCER
Apoptosis-inducing factor (AIF) is a mitochondrial NADH-oxidase originally discovered for its ability to trigger apoptosis through chromatin condensation and DNA cleavage. Although AIF is recognized for its apoptotic function, AIF-mediated cell death has emerged as an atypical cell death pathway; …
-
Caracterização da resposta imunometabólica frente a infecção por Leishmania amazonensis e Leishmania braziliensis em macrófagos de camundongos BALB/C
… and possess the ability to modulate cellular metabolism during infection, favoring their survival. The present study investigates the metabolic alterations induced by Leishmania spp. in the energy metabolism of macrophages, based on the hypothesis that infection promotes mitochondrial …
-
Nox4 mediates metabolic stress responses
Deficits in skeletal muscle mitochondrial metabolism are associated with a wide variety of chronic skeletal muscle and metabolic-related diseases, including diabetes and sarcopenia. Even in patients with advanced skeletal muscle-related diseases, exercise is a well-established method to improve …
-
The Tca Cycle As A Nexus of Metabolic Vulnerabilities In Cancer
… An increasing body of literature suggests that mitochondrial metabolism (tricarboxylic acid cycle (TCA) and oxidative phosphorylation) is imperative for cancer cell growth and proliferation. The scope of the works presented in this dissertation is to explore the importance of mitochondrial …
-
The Epithelial to Mesenchymal Transition In Breast Cancer Induces Alterations In Metabolism
… normal adipose tissue, FOXC2 regulates adipocyte metabolism by promoting the expression of genes associated with energy turnover, insulin sensitivity, differentiation, and mitochondrial biogenesis. I hypothesized that similar to its regulatory role of adipocyte metabolism, FOXC2 dictates metabolic …
Page 1 of 4