Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 198 for “"mitochondrial membrane"”.
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Identification and functional characterisation of different inner mitochondrial membrane supercomplexes
The inner mitochondria membrane (IMM) is densely packed with proteins necessary for mitochondrial activity, including oxidative phosphorylation (OXPHOS) complexes and transporters. Mitochondrial respiratory chain (MRC) complexes, which generate ATP by OXPHOS, associate in higher-order assemblies, …
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Influence of mitochondrial membrane potential on the cryopreservation survival of hepatocytes
… agents and optimizing cooling rates. Membrane-permeable cryoprotectants, such as dimethyl sulfoxide, though widely used, can be extremely toxic to the cell. More natural, non-membrane-permeable cryoprotectants, inspired by freeze-tolerant animals have also been used. A …
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Development of Nanodiamond and Raman Spectroscopy Sensing Methods towards the Measurement of Mitochondrial Membrane Potential in Single Cells
Mitochondrial membrane potential ($\Delta\Psi_{\textrm{m}}$) in cells is a critical biological parameter that is related to diseases such as cancer through biological processes including metabolism, oxidative stress and apoptosis. Studying $\Delta\Psi_{\textrm{m}}$ in normal and diseased states is …
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Metaboloptics: In Vivo Optical Imaging to Enable Simultaneous Measurement of Glucose Uptake, Mitochondrial Membrane Potential, and Vascular Features in Cancer
… primary axes of metabolism are glycolysis and mitochondrial metabolism (OXPHOS), and alteration of either can promote unwanted outcomes in cancer. In particular, increased glucose uptake independent of oxygenation is a well-known mark of aggressive cancers that are more likely to metastasize …
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Distinct C-terminal Amino Acid Sequence Motifs Serve as the Targeting Signals for Outer Mitochondrial Membrane and Plastid Outer Envelope TA Proteins
… are a unique class of functionally diverse membrane proteins that are defined by their single C-terminal transmembrane domain and their ability to insert post-translationally into specific organelles in an Ncytosol-CIMS orientation. While in recent years considerable progress has been made …
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Sideroflexins enable mitochondrial transport of polar neutral amino acids
… transport of metabolites across the inner mitochondrial membrane. While many proteins enabling mitochondrial membrane transport of metabolites are known, how some metabolites are transported is not known, and several mitochondrial amino acid transporters are largely uncharacterized. The …
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5 ns Electric pulses evoke longer-lived calcium responses in adrenal chromaffin cells than the physiological stimulus: an experimental and computational study
… influx through VGCCs, and a disruption of mitochondrial membrane potential has been shown to delay calcium clearance, our first aim was to explore whether 5 ns pulses affect mitochondrial membrane potential using fluorescent mitochondrial membrane potential dyes. Control experiments …
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Functional and Pathophysiological-morphological Correlates of Neurodegenerative Diseases
… selected correlates in Huntington's disease and mitochondrial membrane protein-associated neurodegeneration (MPAN). It uses various methodological approaches such as basic laboratory research, clinical work, imaging, database formation, and database summary. Changes in the amount of respiratory …
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Early hippocampal dysfunction in a mouse model of dementia with Lewy bodies: Mechanisms of cellular dysfunction caused by alpha-synuclein accumulation
… DLB-specific mouse model, focusing on changes in mitochondrial function. Additionally, I explore the role of the wild-type and a DLB-related mutation of the protein beta-synuclein on mitochondrial function. The novel mouse model, known as CamS120, expresses a truncated form of the human …
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The Role of Bax and Bak in Necrotic Cell Death
… in cells deficient for Cyclophilin D (CypD), a mitochondrial prolyl isomerase that resides in the matrix of the mitochondria. CypD is required for programmed necrosis because it regulates the mitochondrial permeability transition pore (MPTP). The MPTP is thought to span the intermembrane space …
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Novel Synthetic Compound, KR-22332, has radio-protective effect through inhibition of Mitochondrial Dysfunction and ROS Generation
… reactive oxygen species generation, and mitochondrial membrane potential as well as changes in the signal pathway related to apoptosis were investigated. Then, the embryotoxicity of KR-22332 were explored in a zebrafish model. Radiation-induced apoptosis and altered mitochondrial membrane …
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NMR structural and functional studies of the mithochondrial outer membrane protein VDAC by Thomas J. Malia.
… their primary roles are carried out in the outer mitochondrial membrane. Anti-apoptotic Bcl-xL has been found previously to interact with VDAC, an outer mitochondrial membrane protein responsible for metabolite trafficking. Here, the NMR-based investigation of VDAC and its interaction with Bcl-xL …
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Biostabilization of Lipid Bilayers: Dealing with Water Stress in Embryos of Artemia franciscana
… to differentially solubilize the outer and inner membranes of mitochondria isolated from A. franciscana. Release of AfrLEA3m occurred simultaneously with the release of fumarase, a matrix-resident marker. As a second independent method to corroborate the above findings, I demonstrated that …
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Do Elevated Levels of Glutathione Decrease the Toxicity of Plasticizers in Mouse Liver Cells?
… observing cell viability, ATP production, mitochondrial membrane potential, and reactive oxygen species (ROS) production. Results indicate significant toxic effects of DEHP and MEHP from cell viability and ATP assessments and show that the two cell lines respond differently to the different …
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Effect of Quantum Dots, Novel Biological Imaging Agents, in Liver Cells in Vitro
… the effect on cell viability, ATP production, mitochondrial membrane potential and reactive oxygen species (ROS) production. The results showed no significant effect on cell viability, ATP production and ROS production. However, the mitochondrial membrane potential of cells was significantly …
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Interactions of shiga-like toxin-2 (Stx-2) from Escherichia coli O157:H7 and the Bcl-2 family of proteins during host cell programmed cell death
… other Bcl-2 family members such as Bak at the mitochondrial membrane therefore inducing mitochondrial membrane permeabilization (MMP) and its downstream effects.</p>
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Reorganization of mitochondrial architecture during apoptosis and mitophagy as investigated by correlative microscopy
… microscopy to investigate reorganization of mitochondrial architecture during two processes, apoptosis and mitophagy, in an effort to better understand the contribution of membrane remodeling to these biological processes. During apoptosis, Bax/Bak oligomerize and accumulate in and adjacent …
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Isolation and Characterization of Novel Estrogen Binding Proteins: Physiological Implications
… of estrogen and estrogen-like compounds on mitochondrial membrane-bound F0F1-ATPase and my efforts to isolate and identify cell membrane estrogen receptor have led me to discover a novel physiologically relevant estrogen binding protein: tubulin. Tubulin shows high affinity for estradiol and …
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The role of L-carnitine in preventing mitochondrial dysfunction after neonatal hypoxia-ischemia
… of cell death induced by neonatal HI is mitochondrial dysfunction leading to metabolic crisis and apoptosis. L-carnitine (LCAR) is an endogenous compound that transports fatty acids across the mitochondrial membrane for metabolism, buffers endogenous acyl-coA pools and improves the health …
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The role of L-carnitine in preventing mitochondrial dysfunction after neonatal hypoxia-ischemia
… of cell death induced by neonatal HI is mitochondrial dysfunction leading to metabolic crisis and apoptosis. L-carnitine (LCAR) is an endogenous compound that transports fatty acids across the mitochondrial membrane for metabolism, buffers endogenous acyl-coA pools and improves the health …
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