Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"mitochondrial medicine"”.
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Design, Synthesis, and Characterization of a Novel Class of Mitochondrial Delivery Vectors: Mitochondria-penetrating Peptides
… and neurodegenerative disorders. Advancing mitochondrial medicine by probing the subcellular biochemistry or targeting therapeutics into this organelle has motivated the development of effective mitochondrial delivery vectors. Thus, the rational design of novel mitochondrial-specific …
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Interactions with bioenergetics by the mitochondria-targeted anti-apoptotic imidazole fatty acid derivative ‘TPP-IOA’.
The mitochondrial pathway of apoptosis contributes to cell death and tissue degeneration in a variety of human diseases. Targeting the molecular events of this pathway represents a promising therapeutic strategy under pathological scenarios, particularly in tissues with limited regenerative …
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EFFECTS OF EXERCISE PRECONDITIONING ON MUSCLE HYPERTROPHY AND MITOCHONDRIAL REMODELING FOLLOWING THE SUBSEQUENT RESISTANCE TRAINING
… hypertrophy of muscle fiber depends on mitochondrial biogenic progression. Moreover, the majority of genes that encode mitochondrial proteins are within nuclear genome. Therefore, in this study, we investigated the effect of increased number of myonuclei in response to the previous …
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Mitochondrial dysfunction in hereditary optic neuropathies
MITOCHONDRIAL DYSFUNCTION IN HEREDITARY OPTIC NEUROPATHIES Mitochondrial pathologies are a heterogeneous group of clinical manifestations characterized by oxidative phosphorylation impairment. At the beginning of their recognition mitochondrial pathologies were regarded as rare disorders but indeed …
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Relationships in slow motion. How sequence evolution can be exploited to predict functional relationships between proteins
Contains fulltext : 117568.pdf (Publisher’s version ) (Open Access)
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New gene defects for human complex I deficiency.
Contains fulltext : 90832.pdf (Publisher’s version ) (Open Access)
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Disease biology of mitochondrial complex-I: Proteomics insights
Contains fulltext : 110935.pdf (Publisher’s version ) (Open Access)
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Identification and functional characterisation of different inner mitochondrial membrane supercomplexes
… is densely packed with proteins necessary for mitochondrial activity, including oxidative phosphorylation (OXPHOS) complexes and transporters. Mitochondrial respiratory chain (MRC) complexes, which generate ATP by OXPHOS, associate in higher-order assemblies, known as supercomplexes (SC), that …
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The Molecular Anatomy of Mitochondrial Disease: Identification and Characterisation of Novel Nuclear-Encoded Mitochondrial Disease Genes
Mitochondrial diseases are a group of clinically and genetically heterogeneous disorders typically associated with abnormal oxidative phosphorylation (OXPHOS). In recent years, next generation sequencing technologies have allowed for accurate genetic diagnoses of inherited mitochondrial diseases …