Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"mitochondrial injury"”.
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INTRA-MITOCHONDRIAL INJURY DURING ISCHEMIA-REPERFUSION
Cardiac injury is increased following ischemia-reperfusion. Mitochondria are the “effector organelles” that are damaged during ischemia (ISC) when there is no blood flow. Resumption of metabolism by damaged mitochondria during reperfusion (REP) results in increased cell injury. Current therapeutic …
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Characterization of Palmitic Acid Induced Lipotoxicity in Schwann Cells
… lysosomal membrane destabilization preceded mitochondrial membrane depolarization, oxidative stress and caspase 3/7 activation. The release of cathepsin L and B were also observed with PA treatments. However, in hyperglycemic SCs, PA-LTx induced- ER stress followed mitochondrial injury, …
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EFFECTS OF STRESS HYPERGLYCEMIA ACCORDING TO DIABETICSTATUS IN PATIENTS WITH ST-ELEVATION MYOCARDIALINFARCTION AND ITS RELATIONSHIP WITH CARDIAC CELL INJURYAND MITOCHONDRIAL DAMAGE: A TRANSLATIONAL APPROACH
… Moreover, AH may exacerbate, thorough mitochondrial dysfunction, infarct size (IS). We investigated the association between AH and chronic glycemia, considered separately or in combination, with mitochondrial injury and myocardial IS in STEMI patients with or without DM. Methods: We …
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Mechanisms of methylenedianiline toxicity to rat biliary epithelial cells
… however, suggested a possible role of mitochondrial dysfunction in the ability of BEC to maintain glucose transport and tight junction integrity. The working hypothesis for this dissertation project was that DAPM alters tight junction integrity and/or glucose absorption by mechanisms …
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Cellular regulation of platelet glycoprotein VI : in vivo and in vitro studies in mice
… is essential to limit blood loss after tissue injury. However, upon rupture of atherosclerotic plaques, this interaction may result in blood vessel occlusion leading to life threatening diseases such as myocardial infarction or stroke. Among the subendothelial matrix proteins, collagen is …
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Osteoarthritis: the role and mechanisms of the chondroprotective peptide Urocortin I
… agents, which protect against NOinduced mitochondrial injury, may have therapeutic potential in Osteoarthritis. The CRF related peptide, Urocortin I (UCNI), has been shown to protect the human chondrocyte cell line, C-20/A4, from SNAP/NO induced apoptotic death, but little is yet known …