Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 60 for “"mitochondrial dynamics"”.
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TAp73 regulates mitochondrial dynamics through an OPA1 axis
… the processes of fusion and fission to couple mitochondrial function with changing cellular demands. In this thesis, I have identified a new molecular mechanism involving TAp73/OPA1 that controls mitochondrial morphology (Buckley et al., 2020). OPA1 drives fusion of the inner mitochondrial …
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The Effect of Mitochondrial Dynamics on Cell Cycle Progression
… were collected and analyzed for the changes in mitochondrial DNA copy number and mitochondrial mass. We found that mitochondria mass gradually increased from G1 phase to mitotic phase and reduced back at the returning G1 phase. However, mtTFA, NRF-1, PRC, known as transcriptional factors …
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Mitochondrial dynamics in the radiation response of cancer cells
… that determine the response of cells to damage. Mitochondrial fission and fusion are associated with cell cycle regulation, apoptosis, cellular bioenergetics and redox status, which contribute to cellular homeostasis and damage response. The study aimed to describe and correlate cancer cell …
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Mechanisms of Regulation of Mitochondrial Dynamics by the Actin Cytoskeleton
… We investigated mechanisms of regulation of mitochondrial dynamics by the actin cytoskeleton. First, we examined actin’s influence over equivalent mitochondrial partitioning between daughter cells in mitosis. Propagating in the space surrounding mitochondria is a wave of actin polymerization …
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The Role of FAM21 in the Regulation of Mitochondrial Dynamics
Mitochondrial network remodelling is crucial for cells to adapt and respond to metabolic cues and stress signals. Processes collectively known as mitochondrial dynamics, including ongoing cycles of fusion and fission, regulate mitochondrial shape, size and distribution, governing mitochondrial …
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Characterisation of new factors regulating mitochondrial dynamics and cellular metabolism
… Recently, the uncharacterised protein, mitochondrial fission regulator 1 like protein (MTFR1L), has been identified as a substrate for the metabolic kinase adenosine monophosphate kinase (AMPK). Phylogenetically, MTFR1L has been categorised within the mitochondrial fission regulator 1 …
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Mitochondrial Dynamics: Exploring A Novel Target Against Myocardial Ischemia-Reperfusion Injury
<p>Mitochondrial fusion and fission, collectively termed mitochondrial dynamics, are among the core mechanisms responsible for maintaining mitochondrial health and functional integrity. Dynamin-related protein 1 (DRP1) is a key regulator of mitochondrial fission. Recent studies suggest that i) …
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Mitochondrial dynamics in demyelinated axons in a cerebellar slice culture system
… stationary sites of mitochondria, increased mitochondrial activity and increased transport speed of mitochondria. This axonal response of mitochondria to demyelination (ARMD) is protective, as there is an increase in energy demand due to the redistribution of sodium channels along the axon …
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Characterisation of Mitochondrial Dynamics and Mitochondrial DNA Inheritance in Drosophila melanogaster
… organelles and there is mounting evidence that mitochondrial dysfunction is linked to a variety of diseases. During spermatogenesis in <i>Drosophila melanogaster</i>, the organisation of mitochondrial networks is altered during each stage of development. This thesis is focused on a novel …
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Autism Spectrum Disorder and Mitochondrial Dysfunction: The Role of Mitochondrial Dynamics
… disorder (ASD). Our research group reported that mitochondrial dysfunction was associated with ASD in South African children diagnosed with ASD using differential methylation and metabolomics studies. Propionyl-CoA Carboxylase Subunit Beta (PCCB) was differentially methylated in our cohort ASD …
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Investigating mitochondrial dynamics in Drosophila spermatogenesis: a focused study on the mitoball
… – is accompanied by substantial alterations in mitochondrial shape, quantity, and distribution. Previous studies have mainly focused on mitochondrial dynamics in post-meiotic spermatids, consequently little is known about mitochondrial dynamics during early spermatogenesis and its impact on …
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Mitochondrial Dynamics Alteration in Astrocytes Following Primary Blast-Induced Traumatic Brain Injury
… approach to the role of mitochondria dynamics dysfunction in bTBI; however, changes in astrocyte-specific mitochondrial dynamics have not been characterized. As a result of fission and fusion, the mitochondrial structure is constantly altering shape to respond to physiological stimuli …
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Insulin-like growth factor 1 effects on mitochondrial dynamics and mitophagy in cancer
… in some pathologies, whether it is essential for mitochondrial homeostasis in tumour cells remains mostly unknown. Mitochondria are key organelles for energy production, and, therefore, cancer cells rely on mitochondrial maintenance to support rapid cell proliferation. In this thesis, the effects …
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Role of Mitochondrial Dynamics and Autophagy in Removal of Helix-Distorting Mitochondrial DNA Damage
… to translate these proteins. Over 300 pathogenic mitochondrial DNA (mtDNA) mutations have been shown to cause a number of mitochondrial diseases emphasizing the importance of mtDNA maintenance and integrity to human health. Additionally, mitochondrial dysfunction and mtDNA instability are linked …
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Investigating the effects of Wnt/β-catenin Signalling on Melanoma Cell Metabolism and Mitochondrial Dynamics
… of mitochondria with higher levels of mitochondrial networking and they show significant changes in the proteins of mitochondrial dynamics. Observed changes in mitochondrial fusion and fission proteins including MFN1, MFN2, OPA1 and DNM1L suggest that activation of Wnt/β-catenin …
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Mitochondrial Dynamics Imbalance as a Potential Driver of Neuronal Decline in the Aging Nervous System of Lymnaea stagnalis
… decline has become increasingly important. Mitochondrial dysfunction has long been implicated in the aging process, as neurons rely heavily on mitochondrial metabolism to meet their high energetic demands. However, the specific mechanisms through which mitochondrial dysfunction contributes …
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Investigating a Mitochondrial Fission Inhibitor as a Therapeutic for Inflammatory Bowel Diseases
Unbalanced mitochondrial dynamics exacerbates inflammation and is of interest for its possible role in the pathogenesis of inflammatory bowel disease (IBD). The current study utilized the P110 peptide drug, a selective inhibitor of mitochondrial fission, to investigate the relationship between …
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Axonal transport and life cycle of mitochondria in Parkinson's disease model
… Parkinson’s disease, has been implicated in mitochondrial dynamics and removal. However, it is not clear how Parkin plays a role in mitochondrial turnover in vivo, and whether the mature neurons possess a compartmentalized Parkin-dependent mitochondrial life cycle. Using the live …
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