Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"mitochondrial defects"”.
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Identification of Mitochondrial Defects and Metabolic Consequences in Lynch Syndrome-Related Endometrial Cancer
… mouse model for LS-EC revealed mitochondrial dysfunction in EC pathogenesis. <strong>This new insight led to the central hypothesis of this dissertation: mitochondrial dysfunction is a novel carcinogenic phenotype of LS-related EC development.</strong></p> <p><strong> </strong>My …
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Effect of mitochondrial respiratory defecton hepatocellular carcinoma :Involvement of mtOGG1 and NUPR1
Many solid tumor cells exhibit mitochondrial respiratory impairment. However, the mechanisms of such impairments in cancer development remain unclear. In this study, to investigate an effect of mitochondrial dysfunction on hepatocellular carcinoma, the two projects were studied. The first project …
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Involvement of mitochondrial dysfunction during transforming growth factor β1-induced senescence-like growth arrest of MvlLu cells
… the senescence, recent studies have emphasized mitochondrial DNA hypothesis because mitochondria is the major ROS generator in addition to its high vulnerability to oxidative damage. Transforming growth factor β1 (TGF β1) has well been known to suppress epithelial cell growth and recently been …
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Reductive Carboxylation Is a Novel Pathway of Glutamine Metabolism That Supports the Growth of Tumor Cells with Metabolic Defects
… acid cycle that disable normal oxidative mitochondrial function. Importantly, it has been unknown how these cells generate the biosynthetic precursors required for growth. To address this, I used models of mitochondrial dysfunction in isogenic cancer cell lines and studied their metabolism …
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Mitochondrial Involvement in Pancreatic Beta Cell Glucolipotoxicity
… conclusively. In this thesis by exploring mitochondrial energy metabolism in INS-1E insulinoma cells and isolated pancreatic islets, a role of mitochondria in pancreatic β-cell glucolipotoxicity is uncovered. It is reported that prolonged palmitate exposure at high glucose attenuates …
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Investigating Cell-Type-Specific Vulnerability in Mitochondrial Disease Using Stem Cell-Derived Neuronal Models
Mitochondrial diseases are a group of widely heterogeneous genetic disorders that primarily affect tissues with high energy demands. Although disruption of oxidative phosphorylation is a shared hallmark across these conditions, their clinical manifestations display remarkable tissue specificity, …
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Post-translational control of mitochondria by Fbxo7 in Parkinson's disease
… the substantia nigra. At a cellular level, mitochondrial dysfunction, oxidative stress and proteasomal dysfunction are all implicated in the pathogenesis of the disease. The majority of PD cases are late onset and arise sporadically, with age being the primary risk factor. Approximately …
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Respiratory chain deficiency alters cellular proteostasis and triggers Alzheimer’s disease-like tau alterations
… fairly well with disease progression. Widespread mitochondrial dysfunction accompanies decreased glucose consumption. AD mitochondria display changes in number, ultrastructure, and enzyme activity. The evidence for mitochondrial dysfunction in AD is clear, however, the notion that defective …
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Mitochondrial dynamics in demyelinated axons in a cerebellar slice culture system
… stationary sites of mitochondria, increased mitochondrial activity and increased transport speed of mitochondria. This axonal response of mitochondria to demyelination (ARMD) is protective, as there is an increase in energy demand due to the redistribution of sodium channels along the axon …
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Mechanisms driving the expansion and progression of splicing factor-mutant clonal haematopoiesis
… which, alongside the previously described mitochondrial defects in SF3B1-mutant cells, demanded further investigation. We identified splicing alterations leading to the downregulation of several key proteins within the tricarboxylic acid (TCA) cycle and electron transport chain (ETC) in …
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Defining the role(s) of non-classical tumour suppressor Wwox in cellular function using Drosophila melanogaster genetic modelling
… to regulate cellular homeostasis in cells with mitochondrial dysfunction, with a requirement for the active site of its shortchain dehydrogenase/reductase (SDR) enzyme. Other genetic effectors of the mitochondrial dysfunction were also identified as candidates for further investigation into the …
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Identification of cellular functions of cardiolipin as physiological modifiers of barth syndrome
… is an anionic phospholipid synthesized in the mitochondrial inner membrane. Perturbation of CL metabolism leads to Barth syndrome (BTHS), a life threatening genetic disorder. I utilized genetic, biochemical and cell biological approaches in yeast to elucidate the cellular functions of CL. …