Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"mitochondrial calcium uptake"”.
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Mitochondrial Calcium Uptake: LETM1 and MICU1 Are Mitochondrial Proteins That Regulate Mitochondrial Calcium Homeostasis and Cellular Bioenergetics
Mitochondrial calcium (Ca2+) uptake has been studied for over five decades, with crucial insights into its underlying mechanisms enabled by development of the chemi-osmotic hypothesis and appreciation of the considerable voltage present across the inner mitochondrial membrane (ΔΨm) generated by …
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Mitochondrial response to axonal injury
… to injury. A viral vector (AAV) containing a mitochondrially targeted fluorescent protein (mitoDsRed) as well as fluorescently tagged LC3 (GFP-LC3), an autophagosomal marker, was injected into primary motor cortex, to label the corticospinal tract (CST), of adult rats. The axons of the CST …
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Calcium-dependent mechanisms in the chicken retina
… channels. In this study, I show that inhibiting mitochondrial calcium uptake (MCU) caused a reversible reduction in the Ca2+ current amplitude. Replacing external Ca2+ with Ba2+ minimized the effects of blocking MCU indicating that the Ca2+ influx is the primary source of the inhibition. With …
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Activity-dependent mitochondrial signaling drives GLR-1 dynamics and behavioral sensitization in C. elegans
… of neuronal activity as well as subsequent calcium influx and its downstream signaling on synaptic AMPAR localization. However, how subcellular compartments, such as mitochondria, contribute to localized signaling, and how they affect AMPAR transport and delivery dynamics are still unknown. …
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Identification and functional characterisation of different inner mitochondrial membrane supercomplexes
… is densely packed with proteins necessary for mitochondrial activity, including oxidative phosphorylation (OXPHOS) complexes and transporters. Mitochondrial respiratory chain (MRC) complexes, which generate ATP by OXPHOS, associate in higher-order assemblies, known as supercomplexes (SC), that …
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The Effects of S-glutathionylation on the Structure and Function of the Mitochondrial Calcium Uniporter (MCU)
Most calcium (Ca2+) entry into the mitochondrial matrix is regulated by the mitochondrial calcium uniporter (MCU). The amino (N)-terminal domain (NTD) of MCU is a regulatory component of the channel. S-Glutathionylation of Cys97 on the MCU-NTD leads to robust MCU activation and increased matrix …