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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 76 for “"mitochondrial biogenesis"”.
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Switching the Fate of mRNAs for Mitochondrial Biogenesis
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Role of Nudix-Hydrolase ASMTL in Modulating Mitochondrial Biogenesis of Cancer Cells
… correlated with 14-3-3 interaction-dependent mitochondrial localization of ASMTL. Analyzing mitochondrial function suggests that ASMTL is imperative in the TP53 dependent BAX-BCL2 pathway, which is turned on by inefficient repair of mtDNA damage. Furthermore, after screening 2040 compounds, we …
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Non-canonical roles for STAT1 and STAT2 in mitochondrial biogenesis and fasting homeostasis.
… that STAT1 and STAT2 inhibit the expression of mitochondrial encoded mRNAs by activating type I interferons (IFNβ) under basal conditions. STAT1-/- livers also exhibit elevated levels of nuclear encoded components of the electron transport chain (ETC). Treatment of wild-type mice with IFNβ …
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Molecular Regulation of Mitochondrial Biogenesis in Exercised and Fasted Human Skeletal Muscle: an Examination of Emerging Regulatory Protein
… is widely accepted as the “master regulator” of mitochondrial biogenesis – an increase in mitochondrial content – and much research has been devoted to understanding PGC-1alpha's role in mitochondrial remodeling. However, several studies have demonstrated the dispensability of PGC-1alpha for …
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Yeast Ataxin-2, A Protein with Many Friends: Identification of a Novel Role for Pbp1 in Mitochondrial Biogenesis
… a respiratory environment forces the cell to use mitochondrial respiration, and as a result, mitochondrial biogenesis is induced. Puf3 functions as a glucose sensor in yeast to support mitochondrial biogenesis in respiratory conditions. It facilitates a rapid stabilization of its target …
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Effects of dietary stimulators of metabolism and mitochondrial biogenesis in vitro and in vivo: Implications for metabolic disease
… in metabolism, metabolic gene expression and mitochondrial content. Additionally, human subjects ingested either placebo or RF in a double-blind placebo controlled fashion and metabolic rate and blood pressure were measured at 3 time points for 3 hours post-ingestion. Results: RF enhanced …
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Characterization of the Saccharomyces cerevisiae gene MGP1, a novel member of the ras gene superfamily that functions in the mitochondrial biogenesis
<p>This dissertation characterizes Mgp1p, a mitochondrial protein that functions in mitochondrial biogenesis. Mgp1p is the first protein related to the p21[superscript] H-ras oncoprotein shown to function in mitochondria;The Saccharomyces cerevisiae gene MGP1 was isolated based on its ability to …
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The Effect of Leucine Supplementation on Biomarkers of Mitochondrial Biogenesis and Protein Synthesis in Soleus Muscle of Rats Fed a High-Fat Diet
<p>Mitochondrial dysfunction is a contributing factor to the advancement of various diseases including obesity, diabetes, and cardiovascular disease. Impairment in mitochondria brings about a diminished mitochondrial number and oxidative capacity. Leucine is known to stimulate muscle protein …
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An in vitro investigation of the molecular effects of aging and exercise signaling within human skeletal muscle cells
… muscle may still be suboptimal due to potential mitochondrial dysfunction and oxidative stress. The purpose of the study was to invesitgate the molecular effects of aging in myoblasts related to cell homeostasis, myogenesis, and mitochondrial biogenesis and whether general exercise signaling via …
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Extracellular Superoxide Dismutase Protects Cardiomyocytes During Hyperoxia
… the transcription of nuclear genes important for mitochondrial biogenesis---nuclear respiratory factors (NRF-1 and NRF-2) and their co-regulator PGC-1α---leading to expression of mitochondrial transcription factor A (Tfam), which regulates mitochondrial transcription and replication. Hyperoxia …
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AMP- Activated Protein Kinase (AMPK) Activation for the Treatment of Mitochondrial Disease
… kinase (AMPK) is a kinase that can initiate mitochondrial biogenesis and mitophagy. We hypothesized that treating cells harbouring low numbers of mtDNA with an AMPK activator (5-Aminoimidazole-4-carboxamide ribonucleoside; AICAR) would ameliorate the decrease in ETC activity and improve mtDNA …
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High intensity exercise induced regulation of the microRNA biogenesis pathway
… and adapt to physiological stress, cells rely on mitochondrial biogenesis – the process of creating new components of the mitochondrial reticulum. Recent studies suggest that microRNAs (miRNA) – small noncoding RNA molecules that fine-tune gene expression by silencing mRNAs through translational …
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MITOCHONDRIAL DNA COPY NUMBER AND AUTOPHAGY IN THE AGING BRAIN AND IN AN ALZHEIMER MOUSE MODEL
Decreased mitochondrial function is associated with aging and is an early step in Alzheimer's disease (AD). Autophagy also declines with age and is required for degradation of dysfunctional mitochondria but it is not known whether autophagosomal formation is overactive and/or degradation of …
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Examining the relationship between mitochondrial dysfunction and Parkinson's disease pathology: a review on potential risk factors and treatments for parkinsonism
… neurotransmission. Past evidence indicates that mitochondrial dysfunction plays a significant role in the progression of degenerative pathologies in the brain. In this review, genetic factors and biochemical mechanisms representative of healthy mitochondrial structure and function are examined to …
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Insulin-like growth factor 1 effects on mitochondrial dynamics and mitophagy in cancer
… in some pathologies, whether it is essential for mitochondrial homeostasis in tumour cells remains mostly unknown. Mitochondria are key organelles for energy production, and, therefore, cancer cells rely on mitochondrial maintenance to support rapid cell proliferation. In this thesis, the effects …
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Exercise-induced cell signalling responses of human skeletal responses of human skeletal muscle: the effects of reduced carbohydrate availability
… endurance exercise induces skeletal muscle mitochondrial biogenesis. However, the optimal training stimulus and nutritional intervention for which to maximize mitochondrial adaptations to endurance exercise is not well known. Developments in molecular techniques now permit the examination of …
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Muscle adaptations to post-exercise cooling
… reduced muscle metabolism might attenuate mitochondrial biogenesis via inhibiting AMPK activation or via a decrease in the Q10 effect. Conversely, cooling in cell and rodent models has been shown to up-regulate the expression of the transcriptional coactivator PGC-1α, which is implicated in …
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Effects of Quercetin Supplementation on Physical and Mental Functions in Older Adults
… decline and multiple adverse health outcomes. Mitochondrial dysfunction and chronic inflammation have been recognized as potential biological mechanisms in contributing to fatigue in the elderly. Since the past decade, efforts to understand the molecular basis of disease prevention, health …
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EFFECTS OF HISTONE DEACETYLASE INHIBITORS ON ENERGY METABOLISM
… development of T2DM. In skeletal muscle, loss of mitochondrial function is evident in some insulin-resistant subjects years before they develop diabetes. Mitochondria are particularly important for skeletal muscle function, given the high oxidative demands imposed on this tissue by intermittent …
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Nutritional Manipulation of Exercise Induced Skeletal Muscle Cell Signalling: Implications for Acute Training Adaptations
… sessions in an attempt to simultaneously promote mitochondrial biogenesis, muscle protein synthesis (MPS) and improve net muscle protein balance. The aim of this thesis was to assess the effects of reduced CHO but high protein availability on the regulation of molecular pathways associated with …
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