Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"mitochondrial bioenergetics"”.
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Cardioprotective mechanisms targeting thiol redox homeostasis and mitochondrial bioenergetics
… and cardioprotection through the manipulation of mitochondrial thiol status. Hearts from exercised rats were better protected from ischemic insults, and this coincided with preserved thiol redox homeostasis and greater stability in mitochondrial bioenergetics. The maintenance of mitochondria thiol …
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Microtubule Regulation of Mitochondrial Bioenergetics in Cardiac and Skeletal Muscles
A novel model of mitochondrial bioenergetic regulation has been proposed whereby microtubules may directly influence the permeability of ADP into the mitochondria to stimulate the production of ATP. Specifically, tubulin, the structural unit of microtubules, physically inserts into the voltage …
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Arsenic Toxicity and Altered Mitochondrial Bioenergetics in Response to Oxidative Stress
… arsenic exposure and how cells cope with altered mitochondrial bioenergetics is an important building block for future studies on arsenic toxicity and for developing treatments for arsenic exposure.
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Exploring the Role of Mitochondrial Bioenergetics and Metabolism in Heart Failure
… the heart undergoes dramatic alterations in mitochondrial fuel metabolism and bioenergetics. As such, there is considerable interest in the delineation of regulatory events involved in the metabolic dysfunction of heart failure. Previous collaborative work identified three metabolic …
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Novologue Therapy Improves Mitochondrial Bioenergetics and Modulates Transcriptome Changes in Diabetic Sensory Neurons
… with scarce treatment options. Impaired neuronal mitochondrial bioenergetics contributes to the pathophysiologic progression of DPN and may be a focal point for disease management. We have demonstrated that modulating Hsp90 and Hsp70 with the small-molecule drug KU-32 ameliorates psychosensory, …
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Účinek agonistů nukleárních receptorů (FXR, CAR, aj.) na játra a hepatocyty za různých stavů
… pharmacological treatment options remainlimited.Mitochondrialdysfunctionrepresentsone of the key pathophysiological mechanisms involved in the development and progression of this disease. The farnesoid X receptor (FXR) is an important regulator of lipid, carbohydrate,and bile acid metabolism,and …
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SIRT1 ACTIVATION IMPROVES HEART FUNCTION THROUGH INHIBITION OF INFLAMMATION IN CHAGAS DISEASE
… oxidative/inflammatory stress and decreased mitochondrial bioenergetics. SIRT1 senses the redox changes and integrates mitochondrial metabolism and inflammation; and SIRT1 deficiency may be a major determinant in CCM. To test this, C57BL/6 mice were infected with Trypanosoma cruzi (Tc), …
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MULTI-OMICS PROFILING DECODES BACE2-DEPENDENT METABOLIC REWIRING IN METASTATIC MELANOMA
… oxidative stress, ultimately compromising mitochondrial bioenergetics. These perturbations progressively force cells to rely on glucose metabolism, unveiling a potential therapeutic vulnerability. Moreover, succinate dehydrogenase activity appears impaired, further exacerbating …
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Mitochondrial Dysfunction: A Mechanistic Link in the Progression from Normal Aging to Sporadic Alzheimer’s Disease
… are crucial for synaptic physiology, and mitochondrial dysfunction, especially of synaptic mitochondria, has been widely recognized as a hallmark pathological feature in both normal aging and sporadic Alzheimer’s disease (AD). Aging and sporadic AD are closely linked, with aging …
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Targeting neurodegenerative phenotypes and mitochondrial dysfunction in a Drosophila Melanogaster model of Parkinson’s Disease
… sleep disturbances, and autonomic dysfunction. Mitochondrial dysfunction, particularly involving Complex I of the electron transport system and mitophagy pathways, is significantly affected in the pathogenesis of PD. This study investigates the roles of NUBPL and PINK1 mutations in mitochondrial …
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Biochemical Thermodynamic Modelling of Cellular Bioenergetics: A Quantitative Systems Pharmacology Approach
… order to assess drug redox cycling and cellular bioenergetics. It is widely accepted that pharmacological activity of certain classes of drugs (e.g. anticancer, antimalarial) is related to their ability to accept one or two electrons. However, pharmacological activity via redox cycling is an …
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PERM1-Mediated Metabolic Crosstalk Between the Heart and Skeletal Muscle in Pressure Overload-Induced Heart Failure
… metabolic dysregulation; however, its underlying bioenergetics remain unclear. PERM1, a striated muscle-specific regulator of mitochondrial bioenergetics, is highly expressed in the heart and skeletal muscle. We previously demonstrated that PERM1 is downregulated in failing hearts; however, …
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The Effect of Alhagi maurorum Medik on Mitochondrial Function
Mitochondrial bioenergetics are crucial for the optimal activity of the cell and are emerging therapeutic targets for the treatment of several metabolic syndromes and cancer. Alhagi maurorum plant is traditionally used in several clinical conditions due to its potential anti-inflammatory, …
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Role of PERM1 in the Development of Insulin Resistance and Diabetic Cardiomyopathy During High-Fat Diet Feeding
… is a striated muscle-specific regulator of mitochondrial bioenergetics, predominantly expressed in skeletal and cardiac muscle. Our group has previously demonstrated that PERM1 is downregulated in both human and mouse failing hearts, and that Perm1-knockout mice exhibit reduced cardiac …
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Bioenergetic and Metabolic Signatures of Maternal Overnutrition in the Offspring Heart
… dysfunction. Programmed alterations in mitochondrial respiratory function, substrate metabolism and oxidative stress have been implicated in offspring cardiac alterations, however these bioenergetic and metabolic phenotypes remain poorly defined. This thesis aimed to investigate cardiac …
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Integrative multiomic insights into Alzheimer’s disease pathology
… a component of vitamin B, is essential for both mitochondrial bioenergetics and DNA repair through NAD<sup>+</sup>-consuming poly (ADP-ribose) polymerases (PARPs). I found that increasing the bioavailability of NAD<sup>+</sup> pharmacologically or by suppressing PARP is neuroprotective in fly …
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CHARACTERIZATION OF PLACENTAL AUTOPHAGY AND BIOENERGETICS, AND MATERNAL MICRORNAS PROFILING IN OBESE PREGNANCIES AND GESTATIONAL DIABETES MELLITUS
… by placental autophagy disturbances, mitochondrial (mt) dysfunctions and epigenetic alterations, which could contribute to the pathogenesis of pregnancy-related metabolic diseases. For these reasons the aim of this work was to characterize placental autophagy and mitochondrial …
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Cardiomyocyte-Specific Deficiency of Ketone Body Metabolism Promotes Accelerated Pathological Remodeling
… nuclear magnetic resonance, measurements of mitochondrial bioenergetics, and in vivo high-resolution echocardiographic quantification of hemodynamics. Because the liver is the source of circulating ketone bodies, studies examining myocardial ketone body metabolism are dependent on hepatic …
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Identification of Metabolic Markers as Potential Early Predictors of PFAS- Induced Immunotoxicity
… study, we investigated how PFAS exposure alters mitochondrial bioenergetics in activated B cells to understand potential PFAS-mediated B cell immunotoxicity mechanisms. We examined five PFAS compounds: PFOA and four short-chain PFAS, perfluoro-2-methoxyacetic acid (PFMOAA), …
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