Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"mitochondrial DNA depletion"”.
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Whole Blood Mitochondrial DNA Depletion in Human Immunodeficiency Virus-Infected Children
… transcriptase inhibitors (NRTIs) interfere with mitochondrial DNA polymerase gamma causing significant toxic effects, including fatal lactic acidosis. Little is known about mitochondrial DNA (mtDNA) in human immunodeficiency virus (HIV) infected children who face a lifetime exposure to these …
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Exploring neurodegeneration in Ataxia-Telangiectasia
… (A-T) is a very rare autosomal recessive DNA repair disorder. The condition is characterised by a progressive neurodegenerative disorder. Cancer predisposition, immunodeficiency and respiratory disease can result in premature death. The life expectancy of a patient with A-T is 30 years …
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Modelling and investigating treatments of childhood inherited mitochondrial diseases in zebrafish.
Mitochondrial DNA depletion syndromes (MDDS) are a group of severe, individually rare, clinically heterogeneous disorders that primarily affect children. Affected tissues tend to be those with a high energy demand such as the central nervous system and skeletal muscle. MDDS stem from disruption to …
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Effect of mitochondrial respiratory defecton hepatocellular carcinoma :Involvement of mtOGG1 and NUPR1
Many solid tumor cells exhibit mitochondrial respiratory impairment. However, the mechanisms of such impairments in cancer development remain unclear. In this study, to investigate an effect of mitochondrial dysfunction on hepatocellular carcinoma, the two projects were studied. The first project …
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Mitochondriale Zytopathien : Aufarbeitung der unterschiedlichen Pathogenese ausgewählter mitochondrialer Zytopathien anhand von zwei Fallbeispielen
Mitochondrial cytopathies are a heterogeneous group of diseases with a pathogenesis which is still not completely understood. This paper shows the heterogeneity of mitochondrial diseases on the basis of two clinical cases, the problem of their clinical interpretation and the unanswered questions …