Global ETD Search
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Showing 1 to 6 of 6 for “"mitochondrial DNA copy number"”.
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Mitochondrial DNA Copy Number, Insulinemic Potential of Lifestyle, and Colorectal Cancer
… containing an independent genome, i.e., mitochondrial DNA (mtDNA). It has been increasingly recognized that mtDNA copy number (mtDNAcn) is a biomarker for mitochondrial function and cellular oxidative stress. To date, the few studies that have assessed associations between mtDNAcn and CRC …
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MITOCHONDRIAL DNA COPY NUMBER AND AUTOPHAGY IN THE AGING BRAIN AND IN AN ALZHEIMER MOUSE MODEL
Decreased mitochondrial function is associated with aging and is an early step in Alzheimer's disease (AD). Autophagy also declines with age and is required for degradation of dysfunctional mitochondria but it is not known whether autophagosomal formation is overactive and/or degradation of …
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The Effect of Mitochondrial Dynamics on Cell Cycle Progression
… were collected and analyzed for the changes in mitochondrial DNA copy number and mitochondrial mass. We found that mitochondria mass gradually increased from G1 phase to mitotic phase and reduced back at the returning G1 phase. However, mtTFA, NRF-1, PRC, known as transcriptional factors …
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Mitochondrial function in atherosclerosis and vascular smooth muscle cells
Abstract Mitochondrial function in atherosclerosis and vascular smooth muscle cells Johannes Reinhold Atherosclerosis is the leading cause of death in the Western world. Although mitochondrial DNA (mtDNA) damage has been implicated in atherosclerosis, it is unclear whether the damage is sufficient …
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Investigating the Effects of Markers of Biological Stress on the Association between Adverse Childhood Experiences and Central Artery Stiffness
… of biological stress—telomere length (TL) and mitochondrial DNA copy number (mtDNAcn). Here, the potential effects of TL and mtDNAcn on the association between ACEs and central artery stiffness were examined. It was hypothesized that TL and/or mtDNAcn would be associated with both ACEs and …
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Identification of Mitochondrial Defects and Metabolic Consequences in Lynch Syndrome-Related Endometrial Cancer
<p>Lynch syndrome (LS), defined by mutations in DNA mismatch repair genes including <em>MSH2</em>, carries a 60% lifetime risk of developing endometrial cancer (EC). Mismatch repair deficiency (MMRd) causes hypermutability, which is assumed to be the main driver of LS-related EC development. …