Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"mitochondrial ADP/ATP carrier"”.
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Investigating the substrate binding mechanism of the mitochondrial ADP/ATP carrier
Mitochondrial ADP/ATP carriers catalyse the equimolar exchange of ADP and ATP across the mitochondrial inner membrane, providing metabolic energy for the cell. Crystal structures of the inhibited cytoplasmic-open and matrix-open states support an alternating access mechanism, involving a …
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Probing the conformational changes of the yeast mitochondrial ADP/ATP carrier
The mitochondrial ADP/ATP carrier in the inner mitochondrial membrane imports ADP and exports ATP by switching between two conformational states. In the cytoplasmic state, which can be locked by carboxy-atractyloside, the substrate binding site is accessible to the cytoplasm, whereas in the matrix …
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Mitochondrial ATP production and energy-buffering in the human pathogen Trypanosoma brucei
… plays a vital role in the cellular energy (ATP) provision of the human pathogen Trypanosoma brucei. ATP is produced in the mitochondrial matrix from ADP and inorganic phosphate by substrate-level and oxidative phosphorylation. To maintain the cellular energy provision, ATP has to be exported …
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Structure and regulatory mechanism of human uncoupling protein 1
Uncoupling protein 1 (UCP1) in the mitochondrial inner membrane is responsible for the thermogenic properties of brown adipose tissue. In response to cold exposure, UCP1 is activated by free fatty acids and catalyses proton leak, dissipating the proton motive force, which mitochondria use to drive …
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The role of mitochondrial transporters in human physiology and adverse drug effects
… prescribed medications often cause off-target mitochondrial dysfunction, but the underlying molecular mechanisms are largely unknown. Mitochondrial transport proteins form a significant class of potential off-targets that remain largely unexplored. The main aim of this thesis is to evaluate the …