Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"mitochondria dysfunction"”.
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THE IMPACT OF VASCULAR SMOOTH MUSCLE CELL SENESCENCE ON MITOCHONDRIA DYSFUNCTION AND ANGIOGENESIS
INTRODUZIONE: L'aterosclerosi, principale causa della maggior parte delle malattie cardiovascolari, progredisce dalle strie lipidiche iniziali fino a placche avanzate e instabili che, se soggette a rottura, possono causare eventi potenzialmente letali. Un segno distintivo dell’instabilità della …
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Helicobacter pylori VacA as a mitochondrial targeted pathogenic effector
Mitochondria play a central role in life and death. Although mitochondrial dysfunction is at the core of many diseases, the mechanisms and consequences of mitochondrial targeting and dysfunction induced by pathogenic microbes is poorly understood. The vacuolating cytotoxin (VacA) of the human …
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HMG-CoA Reductase Inhibitors Act Synergistically with UCN-01 Through RAS Inhibition
… hours) and UCN-01 (100 nM, 18 hours) resulted in mitochondria dysfunction, procaspase 3 and 9 cleavage, and PAW degradation along with marked cytochrome C release and apoptosis. Although similar molecular mechanisms have not yet been confirmed in other cancers, our hypothesis holds that enhanced …
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Mitochondrial Dynamics Alteration in Astrocytes Following Primary Blast-Induced Traumatic Brain Injury
… presents a neuro-centric approach to the role of mitochondria dynamics dysfunction in bTBI; however, changes in astrocyte-specific mitochondrial dynamics have not been characterized. As a result of fission and fusion, the mitochondrial structure is constantly altering shape to respond to …
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An Integrated Omics Approach to Define the Molecular Mechanisms of Low Dose, High Charge, High Energy Irradiation (HZE) in Liver
… analysis (IPA), several pathways involved in mitochondrial function were altered after HZE irradiation. Lipids and metabolites also exhibited changes that are connected to mitochondrial function. Molecular assays for determining Complex I activity, mitochondria count and cardiolipin levels …
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Mas Receptor Agonism for the Treatment of Amyotrophic Lateral Sclerosis (ALS)
… (sALS). Glutamate mediated excitotoxicity, mitochondria dysfunction, neuroinflammation, increased oxidative stress, and the formation of protein aggregates are believed to be key mediators implicated in ALS pathology. To address this need, new targets may facilitate more effective drug …
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Role of protein kinase C isozymes in cellular senescence and reversal of senescence in response to 12-O-tetradecanoylphorbol-13 acetate (TPA) treatment in
… in the regulation of cellular senescence. Mitochondrial dysfunction is linked between age-related accumulation of oxidative damage and alterations of physiological function associated with senescence. Recent studies suggest that mitochondrial metabolism is upregulated in oncogene induced …