Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"missing-self recognition"”.
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Genetic Investigation of MHC-independent Missing-self Recognition by NK Cells
… laboratory is to explore the MHC-independent “missing-self” branch of NK recognition, and more specifically, the NKR-P1B:Clr-b receptor-ligand system and its role in bone marrow transplantation. In the first results chapter, we generated hybridoma clones producing monoclonal antibodies against …
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Modulation of Clr-b Ligand for the Inhibitory NKR-P1B NK Cell Receptor in Response to Transformation and Genotoxic Stress
… through germline-encoded receptors. The recognition of targets undergoing genotoxic stress or transformation by NK cells has been limited to the upregulation of stimulatory NKG2DL and “missing-self” recognition of MHC-I. The ligand pair NKR-P1B:Clr-b participates in “missing-self” …