Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"misfolding disease"”.
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A study of the elongation of fibrils of the Alzheimer's amyloid beta protein with a coarse-grained force field
Alzheimer’s disease (AD) is a brain disorder named after the German psychiatrist Alois Alzheimer, who first described the disease in 1906. AD is a form of dementia, characterized by impairment of memory and other intellectual abilities, caused by the loss of neurons and synapses (the structures …
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Biomolecular function and failure across length scales
… fundamental biological questions and enable disease biomarker detection. These advancements enable the discovery of previously unexplored emergent protein functions arising from condensation, such as the formation of electrochemical gradients and antimicrobial activity. Furthermore, this …
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Advances in Microfluidics and DNA Nanotechnology for Biomolecular Analysis
… which are implicated in the pathogenesis of misfolding diseases. In this study, micro-electrophoresis enables the fractionation of heterogeneous protein mixtures in free solution, an operation that is combined with single-molecule microscopy for high-resolution analysis. In a complementary …
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Development of Original and Notable Techniques for Protein Analysis, Native Identification, and Characterisation
This thesis is a compilation of multiple techniques developed to characterise solutions of proteins, or proteins themselves. Proteins are the building blocks of life, and thus they are interesting to study for a deeper understanding of the mechanisms of life but also for developing diagnostic tools …
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Nanolithography and nanoscopy methods for the study of biological samples in confined spaces
Alzheimer’s, Parkinson’s and Huntington’s disease all belong to the group of amyloid pathologies also called protein misfolding diseases. Since the first discovery of amyloid fibrils of the aggregated protein tau in inclusion of Alzheimer brains samples, research has focussed on how amyloids form …