Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"mir-200"”.
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Assessing the temporal role of miR-200 loss in murine models of NSCLC
… (EMT) and immune evasion. The microRNA 200 family is a master regulator of EMT and is implicated in immune regulation. In this study we have developed a novel genetically engineered mouse model (GEMM) and derived primary cell lines from them to explore the role of microRNA-200 in early …
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Antagonistic Roles of miR-199a-3p/miR-214 and the miR-200 Family in the Regulation of Uterine Contractility During Pregnancy and Labor
… understood. Recently, we discovered that miR-200 family members, miR-200b and miR-429, and their target, transcription factor ZEB1, serve as P4/progesterone receptor (PR)-mediated regulators of uterine quiescence during pregnancy (Renthal et al., 2010). In the present study, we identified …
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The Role of Snail Homolog 1 in Embryonic Stem Cell Differentiation
… of ES cell-associated microRNAs, including the miR-200 family. The miR-200 family is down-regulated in a Wnt-dependent manner during ES cell differentiation. We find that maintenance of miR-200 expression prevents EMT and stalls differentiating ES cells at an epiblast-like stem cell: EpiSC) …
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The Regulation of Microrna Biogenesis By Ribosome-Interacting Proteins
<p>MicroRNA (miRNA) are small, non-coding RNAs that affect gene expression through degradation of complementary mRNA targets or inhibition of translation. As they affect approximately 50% of all cellular processes, miRNA are tightly regulated by the cell through transcriptional and …
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Microrna-200 Regulates Ecm-Dependent Β1-Integrin/Fak Signaling and Cancer Cell Invasion
<p>The microRNA-200 family is known to be a master regulator of the epithelial-to-mesenchymal transition, partially through its double-negative feedback loop with the transcriptional repressor Zeb1, yet the mechanisms on how miR-200 controls the invasive phenotype are not fully understood. Recent …
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Post-Transcriptional Regulation by microRNAS in Pregnancy and Parturition
… we uncovered a new regulatory pathway whereby miRNAs serve as hormonally-modulated and conserved mediators of contractile gene regulation in the pregnant uterus from mouse to human. Using miRNA and gene expression microarray analyses of uterine tissues, we identified a conserved family of …
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The hybrid epithelial/mesenchymal phenotype and its implications in cancer metastasis
… EMT/MET – interconnected feedback loops among miR-34, miR-200, ZEB, SNAIL families – to predict that it can act as a ‘three-way’ switch enabling three phenotypes – epithelial (high miR-200, low ZEB), mesenchymal (low miR-200, high ZEB) and hybrid E/M (medium miR-200, medium ZEB). Second, GRHL2 …
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The Role of Cancer-Associated Fibroblasts In Lung Tumorigenesis
… through the suppression of the microRNA-200 (miR-200) family. Cancer-associated fibroblasts (CAF) enhance tumorgrowth and invasion by secreting VEGF-A that binds to VEGFR1, a processrequired for tumor growth and metastasis in mice and correlated with a poorprognosis in lung adenocarcinoma …
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Novel Regulators of Cellular Secretion Alter The Tumor Microenvironment to Drive Metastasis
… (1) Oncogenic targets of epithelial micro-RNAs (miRNAs) are epigenetically de-repressed upon loss of the miRNAs during epithelial-to-mesenchymal transition (EMT) and in cancer. EMT confers plasticity and fitness to cancer cells promoting their survival through the metastatic cascade. This cascade …
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The Role of The Epithelial-To-Mesenchymal Transition (Emt) In Lung Cancer Progression
… the transcription factor Zeb1 and the microRNA-200 family (miR-200). Furthermore, these studies demonstrated that mesenchymal lung cancer cell invasion and metastasis are dependent on interaction with the extracellular matrix (ECM). In addition to metastasis, EMT has been implicated in …
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ZEB1 is a central mediator of the Epithelial-Mesenchymal Transition
… phenotype in the same cells. ZEBI and miR-200 were known to reciprocally regulate each other, but their relative importance to the EMT phenotype had never been directly tested. I found that ZEB1 induced EMT regardless of miR-200c levels, thereby excluding the model in which miR-200c …
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Novel Regulators of Somatic Cell Reprogramming
… was linked to BMP-dependent induction of miR-205 and the miR-200 family of microRNAs. These studies thus defined a multi-step mechanism that incorporates a BMP-miRNA-MET axis during somatic cell reprogramming. Next I focused on the two later phases of reprogramming, maturation and …
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Epithelial to Mesenchymal Transition As A Predictor of Response to Polo-Like Kinase 1 Inhibition-Induced Apoptosis In Non-Small Cell Lung Carcinoma
… The induction of an epithelial phenotype using miR-200 expression increased resistance to PLK1 inhibition, whereas the induction of a mesenchymal phenotype using ZEB1 expression or TGF-β increased PLK1 inhibition–induced apoptosis. To elucidate the mechanisms of resistance to PLK1 inhibition, …
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The P63 Isoform ∆Np63Α Inhibits Epithelial – Mesenchymal Transition By Promoting The Expression of Mir-205 In Human Bladder Cancer Cells
… highlight the role of microRNAs belonging to the miR-200 family and miR-205 in preventing EMT through suppression of ZEB1 and ZEB2. p53, the homologue of p63, is implicated in regulating EMT by modulating the expression of miR-200c; however, the mechanisms underlying miR-205 control remain …
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Functional miRNA-based Phenotypic Screening as a tool to delineate HIV-host interactions and facilitate Novel Drug Discovery
… of novel anti-HIV therapies. microRNAs (miRNAs) are short noncoding RNA molecules that function as part of the endogenous RNA interference system which governs post transcriptional gene regulation. Current knowledge has placed miRNAs at the crux of HIV-host interactions, yet the …
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The Role of microRNAs in Bladder Urothelium Development and Tumorigenesis
… and progress to muscle invasion). MicroRNAs (miRNAs) are single-stranded non-coding RNA molecules, approximately 21-23 nucleotides in length, that regulate gene expression. Since their discovery in 1993, they have emerged as major mediators of cellular functions and tissue homeostasis. …
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AN INVESTIGATION OF POTENTIAL MECHANISMS UNDERLYING CHEMOSUPPRESSIVE EFFECTS OF DIETARY FLAXSEED IN THE LAYING HEN MODEL OF OVARIAN CANCER
… decreased by flaxseed, including E-cadherin and miR-200, suggesting that flaxseed impedes the activity of an aberrantly activated developmental program that controls gland formation during ovarian cancer progression. Lack of nuclear accumulation of ZEB1 protein in tumor cells suggests that this …