Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"minocycline"”.
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Analysis of Minocycline as a Radioprotectant
… emergencies and anticancer radiotherapy. Minocycline, a semisynthetic tetracycline derivative, has anti-inflammatory, free radical scavenging, anti-apoptotic and antiangiogenic properties with exceptional penetration into the CNS. These qualities make it a viable candidate for use in …
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Pulmonary disposition and pharmacokinetics of minocycline in the adult horse
… pharmacokinetics and pulmonary disposition of minocycline in horses after a single intravenous (IV) and intragastric (IG) dose and after multiple IG doses. The study hypotheses were that: minocycline would be present in the pulmonary epithelial lining fluid (PELF) and bronchoalveolar lavage …
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A Pre-Clinical Assessment of Minocycline For Treatment of Chronic Neuropathic Pain After Spinal Cord Injury
… treatments for SCI-dependent CNP.</p> <p>Minocycline, an FDA-approved antibiotic, has been widely prescribed for the treatment of acne for several decades. However, recent studies demonstrate that minocycline has neuroprotective properties in several pre-clinical rodent models of CNS …
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Identification and biophysical characterization of two intralysosomal pigments with free-radical properties and their synthetic models: Human neuromelanin and the minocycline-induced thyroid pigment
… by administration of the tetracycline antibiotic minocycline. Using bovine eye melanin as a control, neuromelanin is found to be an atypical melanin that is poorly modeled by synthetic DA melanin, whereas the thyroid pigment does not qualify as a melanin but is similar to a pigment formed by …
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Multiple Myeloma and Its Treatment Alter Peripheral Nervous System Structure and Function
… study subsequently evaluated the efficacy of minocycline in the prevention of treatment-emergent bortezomib-induced peripheral neuropathy in a double-blind, placebo-controlled, randomized phase I clinical trial by assessing QST and patient reports. The placebo group did not show changes in …
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Mechanisms of Astrocyte Contribution to Bortezomib-Induced Peripheral Neuropathy
… astrocytes and whether changes were prevented by minocycline, an anti-inflammatory drug that vi prevents glial activation, and 3) quantified changes in connexin 43, GLT-1, and GLAST to assess whether astrocytic glutamate transport may be altered in BIPN. The results observed in the first aim were …
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Effect of Antibiotic Pastes on Chemical Structure and Microhardness of Radicular Dentin
… composed of metronidazole, ciprofloxacin, and minocycline. A modified triple antibiotic paste (MTAP) that replaces minocycline with clindamycin has recently been suggested to avoid the tooth discoloration and potential demineralization from minocycline. The effect these pastes have on radicular …
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Characterization of a Nanoparticle Drug Delivery System for the Treatment of Inflammation in Spinal Cord Injury
… efficacy of a well-known anti-inflammatory drug, minocycline, through a NPs delivery tool selectively targeted to microglia/macrophage. We developed and tested a new drug delivery nanocarrier (minocycline loaded in poly-ε-caprolactone NPs, PCL Mino) <i>in vitro</i> and <i>in vivo</i>. …
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The Role of Extracellular Matrix and Matrix-Degrading Proteases in Neonatal Hypoxic-Ischemic Injury
… MMPs, or the anti-inflammatory compound minocycline, could provide neuroprotection when administered at a delayed time point after insult, and to compare the efficacy of AG3340 with that of the well-known anti-inflammatory compound minocycline. Data showed that both compounds effectively …
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Macrophage recruitment in DRG contributes to sensory axon regeneration after conditioning injury
… Continuous infusion of macrophage deactivator minocycline to L5 DRG for 7 days after CI significantly reduced the number of macrophages, and almost completely abolished expressions of proinflammatory cytokines, neurotrophic factors, regeneration associated genes (GAP-43) and oncomodulin at 7 …
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A Role for Microglia Activation in Modulating Behavior in a Variable Stress Model for Depression
… pro-inflammatory activation of microglia with minocycline, a tetracyclic antibiotic, did not prevent the stress effects on behavior. Surprisingly, prior pro-inflammatory activation of microglia with lipopolysaccharide (LPS), an endotoxin from gram-negative bacteria, was protective against …
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Acute, Low-Grade Inflammation elevates White Matter Sensitivity to Ischaemia
… response with the clinically available drug minocycline eliminated the elevated white matter sensitivity to ischaemia following acute, low-grade inflammation. <br/>This study therefore identified that the increase of white matter sensitivity to ischaemia caused by acute, low-grade …
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Investigating the role of neuroinflammation in a mouse model of L-Dopa induced dyskinesia and exploring the anti-dyskinetic potential of a cannabinoid receptor agonist
… and the anti-inflammatory treatment regime of minocycline/indomethacin. Strikingly, all treatment regimes were anti-dyskinetic and concomitantly reduced neuroinflammatory alterations. In summary this thesis was able to show a correlation between neuroinflammatory processes and a dyskinetic …
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Migration of olfactory ensheathing cells grafted into adult rat spinal cord
… the microglial reactivity was dampened using minocycline; and v) OECs survived grafting into cerebrospinal fluid (i.e. subarachnoid space) and migrated into the neuropil of the brain and spinal cord. The major conclusions are that OECs can respond to migratory signal(s) arising as a result of …
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Neonatal Hyperbilirubinemia: <i>in vivo</i> Characterization of Mechanisms of Bilirubin Neurotoxicity and Pharmacological Treatments
… Finally, the administration of minocycline (MNC), an antibiotic with neuroprotective and anti-inflammatory properties, partially prevented lethality by hyperbilirubinemia and rescued animals by significantly reducing neurodegenerative and neuroinflammatory features that …
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Disease mechanisms and markers of progression in cerebral small vessel disease
… aims to answer this question by testing whether minocycline can inhibit activated microglia and stabilise the blood-brain barrier, and I presented baseline data from the trial.
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Mechanisms of microglia induced retinal degeneration
… due to uncontrolledmicroglial activation, I used minocycline to control microglia activation in ourLysMCre-SOCS3fl/flCX3CR1GFP/GFP mice at the age of 5 months (before the onset ofretinal neuronal degeneration) for 3 consecutive months in Chapter 5. The treatmentsignificantly supressed microglial …
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Contribution of microglial reactivity to olfactory ensheathing cell migration in vivo
… the cytokine injection and cell graft; and iv) minocycline treatment both dampened microglial reactivity and significantly reduced the number of migrating DiI+ve OECs. The major conclusions are that the migration of OECs within the adult rat spinal cord occurs in response to migratory signal(s) …
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Axonal Damage in Repetitive Concussive Traumatic Brain Injury: Characterization and Contributing Factors
… None of the compounds tested--including minocycline, (RS)-2-Chloro-5-hydroxyphenylglycine (CHPG), brilliant blue g (BBG), and microRNA-124 (miRNA-124)--were able to reduce the number of iba-1-positive microglia present in the corpus callosum after injury, which were quantified by …
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