Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"minimal inhibitory concentration"”.
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Selection and Characterization of Strains of Staphylococcus aureus Displaying Unusual Resistance to Aminoglycosides
… and significant discrepancies between the minimal inhibitory concentrations and minimal bactericidal concentrations of aminoglycosides have been observed (62,90,116). These observations suggest the presence of a small subpopulation of cells within the sensitive parent strain which are more …
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Discovery and functional study of a bioactive peptide QUB-1892 from the defensive skin secretion of The Edible Frog (Pelophylax eculentus)
… to purify and analyse the mature peptide. Its minimal inhibitory concentration (MIC) was obtained by using different micro-organisms and its haemolytic activity was tested by the use of horse red blood cells. The results of antimicrobial experiments showed that QUB-1892 was active only against …
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Isolation and Characterization of Active Ingredients from Nigella Sativa for Antibacterial Screening.
… For instance, the IC<sub>50</sub> and the Minimal Inhibitory Concentration (MIC) for <em>thymoquinone</em> were found to be 1.31 μg/mL and 3.6 μg/mL respectively, when tested against the gram-positive bacteria, <em>S. aureus</em>. It is also found that <em>thymoquinone</em> significantly …
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Bacteriostatic and bactericidal effects of antibiotics on Bacteroides
… strains. Drugs were considered bactericidal when minimal bactericidal concentration (MBC) to minimal inhibitory concentration (MIC) ratios were less than or equal to four. As expected, metronidazole, cefoxitin and penicillin were bactericidal. However, clindamycin and chloramphenicol, which other …
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Analysis of a novel antimicrobial peptide QUB-1746 from the skin secretion of the frog, Kassina senegalensis
… and analyze the mature peptide QUB-1746. Its minimal inhibitory concentration (MIC) was detected by using different micro-organisms and its haemolytic activity was tested by using horse red blood cells. MTT assay tested two human lung cancer cell lines, H23 and H157, for effects. The results …
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The discovery and functional study of a bioactive peptide, QUB-3273, from the skin secretion of the frog, Odorrana schmackeri
… sequence was synthesised and purified. The minimal inhibitory concentration (MIC) of QUB-3273 was 16 µM (Escherichia coli, E. coli), 32 µM (Staphylococcus aureus, S. aureus), and 64 µM (Candida albicans, C. albicans), respectively. The results showed consistency with the bioactivities of …
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The discovery and functional study of a novel bioactive peptide, QUB-2561, from the defensive skin secretion of the Central American red-eyed leaf frog, Agalychnis callidryas.
… coli and the yeast, Candida albicans. The minimal inhibitory concentration and minimum bactericidal concentration of QUB-2561 against the three above microorganisms were both 2 µM, at which the haemolytic effect of QUB-2561 on horse red blood cells was only 2.53%.<br/>The study of the novel …
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Small Molecules and Their Conjugates with Peptides: Chemical Strategies to Tackle Resistant Bacteria
… prepared and its activity measured through its minimal inhibitory concentrations (MIC). Further optimisations were attempted to understand factors affecting the MIC. The results lead to a conjugate with proven cleavage by β-lactamase and an improved MIC value compared to the non-cleavable …
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An antimicrobial peptide QUB-1925 from scorpion venom of Androctonus bicolor: molecular cloning of biosynthetic precursor-encoding cDNA and bioactivity study
… to induce a very low level of haemolysis at the minimal inhibitory concentration (MIC) of 8 μM ( against S.aureus) and 32μM (against E.coli), respectively. Moreover, QUB-1925 exhibited weak anti-proliferative activities against the human cancer cell lines PC-3, H-23, and U251MG. These data …
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Antibacterial Activities of Cannabidiol Against Two Major Oral Pathogens
… nicotine and P. gingivalis, were evaluated. The minimal inhibitory concentration (MIC), minimal biofilm inhibitory concentrations (MBIC), and minimal bactericidal concentrations (MBC) of CBD were assessed. CBD concentrations ≥ 2.5 μg/ml exhibited significant inhibition (p<0.001) against S. mutans …
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Η ΕΠΙΔΡΑΣΗ ΤΗΣ ΤΑΥΤΟΧΡΟΝΗΣ ΧΟΡΗΓΗΣΗΣ ΦΑΙΝΥΛΒΟΥΤΑΖΟΝΗΣ Η ΙΝΔΟΜΕΘΑΚΙΝΗΣ ΣΤΑ ΕΠΙΠΕΔΑ ΤΗΣ ΚΕΦΑΛΥΡΙΝΗΣ ΣΤΟΝ ΟΡΟ ΚΑΙ ΣΤΑ ΟΣΤΑ ΤΗΣ ΚΑΤΩ ΓΝΑΘΟΥ
… AND MANDIBLE WERE ESTIMATED BY THE METHOD OF MINIMAL INHIBITORY CONCENTRATION (MIC). FROM THE RESULTS AND STATISTICAL ANALYSIS THE FOLLOWING CAN BE CONCLUDED: A) THE INCREASE OF LEVELS OF CEPHAPIRIN IN SERUM AND MANDIBLE AFTER SIMULTANEOUS ADMINISTRATION OF PHENYLBUTAZONE WAS STATISTICALLY …
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Etude de l'activité antifongique des bactéries lactiques isolées de produits alimentaires fermentés et caractérisation de leurs métabolites inhibiteurs
… LC11 were selected among 116 for their strongest inhibitory activity and their broad inhibitory spectrum against food moulds. The 4-fold concentrated supernatant of L. plantarum VE56 and W. paramesenteroides LC11 had the strongest inhibitory activity to compare to W. cibaria FMF4B16. The …
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A novel bioactive peptide from the skin secretion of the Chinese brown frog, Rana chensinensis
… solid phase peptide synthesis and subjected to minimal inhibitory concentration (MIC) assay using different microorganisms, MTT assay using different kinds of cancer cell lines, and haemolytic activity assay using horse red blood cells. The resultsobtained from three individual experiments …
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The discovery and biological activity evaluation of a novel peptide, QUB-3229, from the defensive skin secretion of the Chinese piebald odorous frog, Odorrana schmackeri
… the fungi, Candida albicans (C. albicans). The minimal inhibitory concentration (MIC) values were 16, 8 and 32 μM, respectively. The peptide showed bactericidal activities against the bacteria, but not against the fungi even at the highest tested concentration. The 10% haemolytic concentration …
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The mode of action of Epicoccum derived antimicrobials
… ICMP 19927 through agar diffusion assays, minimal inhibitory concentration (MIC) assays, time-to-kill assays, flash column chromatography, and nuclear magnetic resonance (NMR) spectroscopy. In addition, attempts were made to elucidate its mode/s of action by the combination of …
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Synthesis and Antimicrobial Activity of Half-Sandwich Ir(III), Rh(III), and Co(III) Complexes
… normal cellular processes at up to 40 times the minimal inhibitory concentration (MIC). A study of the MOA or mechanism of action revealed the ability of the amino acid complexes to affect the peptidyl transferase region on the 23s ribosomal subunit of M.smegmatis. This was accomplished by …
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Synthesis, Characterization, Critical Micelle Concentration and Antimicrobial Activity of Two-headed Amphiphiles
… to give the 2CCbn series. The critical micelle concentrations (CMC) were measured by the pyrene-based fluorescent probe method. The pyrene excited at 345 nm and fluoresces with maxima at 374 nm (I1) and 385 nm (I3). The stock solution and the dilution series for each amphiphiles were made in …
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Establishment of a Long Term Cell Culture Model for Testing Anti-Infectives against Mycobacterium avium subsp. paratuberculosis
… JD in cattle, sheep, and goats have only been minimally effective, and there are only medications to treat the symptoms of mycobacterial infections associated with CD in humans. Along with not being able to cure MAP infections, there is no established laboratory animal model for testing …
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Characterization of lactic acid bacteria from Nono, a Nigerian naturally fermented milk product
… tolerance to different acidic pH and bile salt concentrations to characterise their resistance to gastric acid and bile. The survival of the isolates at different acidic pH varied according to the isolates and incubation time, Lactobacillus fermentum followed by Lactobacillus senioris survived …
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Copper tolerance of Listeria monocytogenes strain DRDC8.
… on copper tolerance by DRDC8 was also examined. Minimal inhibitory concentration (MIC) and growth experiments showed that inactivation of cutR, pCT0018 or pCT0019, or removal of plasmid-encoded genes by curing DRDC8 of plasmid DNA, had a significant effect on copper tolerance. In addition, loss …
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