Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"mineralocorticoid"”.
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Mineralocorticoid receptor involvement in vascular dysfunction associated with vascular injury
Mineralocorticoid receptor (MR) signaling has recently been implicated in cardiovascular dysfunction associated vascular injury. Specifically, MR blockade has been shown to treat coronary microvascular dysfunction in obesity and has been implicated in the regulation of capillary density in ischemic …
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A Mineralocorticoid-Dependent Effect of Prestress on Avoidance Responding in Rats
… fluid, a procedure which is known to inhibit mineralocorticoid secretion. Injection of mineralocorticoid, in either adrenalectomized rats or intact NaCl-maintained rats, renewed the effect of prestress and had no effect on the subjects' response rates in sessions not preceded by prestress. …
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Molekulare Mechanismen der Aldosteron-Wirkung und Interaktionen des Mineralocorticoid-Rezeptors in Nierenzellen
Im Rahmen dieser Arbeit sollten Interaktionen des Mineralocorticoid-Rezeptors (MR) sowie Regulationsmechanismen des MR durch Aldosteron in Nierenzellen untersucht werden. In früheren Versuchen am Institut für Klinische Pharmakologie Mannheim wurde die schnelle (2h) Aldosteron-induzierte …
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Analysis of the role of the mineralocorticoid receptor in renal principal cell sodium reabsorption in vivo
Germline inactivation of the mineralocorticoid receptor (MR) gene in mice results in early postnatal lethality due to massive loss of sodium and water associated with impaired epithelial sodium channel (ENaC) activity in kidney and colon. The aim of the present study was the analysis of the role of …
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Investigation of different blood pressure regulating systems in kininogen-deficient BNK rats
… in BNK rats are in fact attributable to enhanced mineralocorticoid action. The renal mineralocorticoid receptor (MR) displayed an overexpression and several mutations that might be responsible for altered affinity and responses toward aldosterone and other ligands, e.g. DOC and corticosterone. …
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Role of serotonin in the regulation of aldosterone secretion from the rat adrenal gland
… role of serotonin in the control of mineralocorticoid secretion still remains to be elucidated.
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Sympathetic nervous system in the development of mild DOCA-salt hypertension
… of human hypertension. Recent evidence points to mineralocorticoids as a cause of sympathetic overactivity in hypertension. In the studies for this dissertation, low dose deoxycorticosterone acetate along with high salt in drinking water with both kidneys intact was used as a model (mild DOCA-salt …
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Dietary Electrolytes and their Influences on Plasma Aldosterone Concentration
… excretion, and plasma levels of aldosterone, a mineralocorticoid hormone that has been linked to incidence hypertension, in a cohort of healthy children and young adults. We found that higher plasma aldosterone level was associated with lower sodium excretion in the urine, in blacks and whites, …
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Sgk1 como mediador de los efectos deletéreos del receptor de mineralocorticoides
The mineralocorticoid receptor (MR) plays a central role in mineral homeostasis, extracellular volume control and blood pressure regulation. However, MR is expressed in others tissues not directly related with these processes, where it can be activated by both mineralocorticoids and …
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Corticosteroid hormone action in the cardiovascular system
… an important target of corticosteroid hormones. Mineralocorticoid receptor antagonists provide cardiovascular protection and are now routinely used in disorders such as primary hyperaldosteronism, resistant hypertension and congestive heart failure (CHF) but the underlying molecular mechanisms of …
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Role of 11β-hydroxysteroid dehydrogenase type 2 in protection against inflammation during atherogenesis: studies in the Apoe-/- /11β-HSD2-/- double knockout mouse.
… and progression of cardiovascular disease. Mineralocorticoid receptor (MR) over-activation has been implicated in atherosclerosis. In mineralocorticoid-target tissues, 11β- Hydroxysteroid dehydrogenase type 2 (11β-HSD2) inactivates glucocorticoids, conferring aldosterone specificity upon the …
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Pathophysiological role of aldosterone in cardiac remodelling after myocardial infarction
… genetic and neurohormonal factors, including the mineralocorticoid hormone aldosterone, are implicated in its pathogenesis. Aldosterone antagonism reduces cardiovascular morbidity and mortality in patients with advanced chronic HF and survivors of large AMI who develop HF and/or are diabetic. …
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Exploring the Glucocorticoid Actions of 1α-Hydroxycorticosterone (1α-OH-B) in the Elasmobranch Fishes
… acts as both the primary glucocorticoid (GC) and mineralocorticoid (MC) in these fishes, a dual role analogous to that of cortisol in the teleost fishes. The MC characteristics of 1α-OH-B are well supported, but data supporting its GC functions are lacking. In this study, the putative GC actions …
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Renal Epithelial Sodium Channel (ENaC) Regulation of Pregnancy Mediated Hemodynamic Adaptations: Mechanistic Insights
… was abolished by pretreatment with the mineralocorticoid receptor antagonist, eplerenone. These findings demonstrate that the increased α ENaC subunit of pregnancy is associated with a mineralocorticoid-dependent increase in ENaC activity. The plasma volume increased progressively during …
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Human aldosterone synthase and 11[beta]-hydroxylase: studies on the relationship of structure and function and their clinical implications
… hypertension due to abnormally high levels of mineralocorticoid, DOC. Mutations have been identified which destroy aldosterone synthase 18-hydroxylase activity or 18-oxidase activity or both, resulting in lack of aldosterone. Structure-function studies have identified aldosterone synthase …
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The role of p90 ribosomal S6 kinases (RSKs) in Steroid signalling
… glucocorticoid, estrogen, progesterone and mineralocorticoid receptors). These proteins regulate gene expression thus are involved in crucial biological processes, including organ development and maintenance, the immune system, neuroprotection and metabolic homeostasis. Importantly, SRs are …
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Regulation of Functional Expression of Mechanosensitive Trpv4 Channel In The Distal Nephron By Dietary Potassium and Sodium Intake
… aldosterone action, since saturation of systemic mineralocorticoid signaling with DOCA, a precursor of aldosterone, had little effect on TRPV4 protein abundance in the kidney. Confocal immunofluorescence in split-opened DNs showed that high K<sup>+</sup> and Na<sup>+</sup> intake resulted in …
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Characterization of Rapid Nongenomic Cortisol Signalling in Rainbow Trout Liver
… receptors, glucocorticoid receptor (GR) and mineralocorticoid receptor (MR), whereas the nongenomic cortisol response involves rapid changes to downstream second-messenger signalling cascades independent of gene regulation. However, nongenomic glucocorticoid signalling remains poorly …
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Exploring the bidirectional interface between stress and innate immunity: a focus on glucocorticoid and TLR4-MyD88 signalling
… that the priming effect on IL-1β was mediated by mineralocorticoid receptor (MR) signalling, while immunosuppressive actions were mediated by glucocorticoid receptor (GR) signalling. Study 3 further assessed glucocorticoid actions on non-cytokine innate immune responses via measurements of cell …
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Comparing Healthcare Resource Utilization and Costs in HFPEF patients using SGLT2-inhibitor Combination Treatments: A Retrospective Claims Analysis
… therapy, with the addition of either mineralocorticoid receptor antagonists (MRAs) or angiotensin receptor-neprilysin inhibitors (ARNIs) as adjunctive therapy. However, real-world evidence comparing healthcare resource utilization (HCRU) and costs between these combination therapies …
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