Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"midostaurin"”.
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Concomitant Inhibition of Flt3 and Mcl-1 In Flt3 Mutated Acute Myeloid Leukemia
… S63845 synergizes with the FLT3 inhibitor midostaurin for potent anti-leukemic effect in preclinical human models of FLT3-ITD mutated acute myeloid leukemia (AML). Acute Myeloid leukemia (AML) is a neoplastic blood disorder defined by a characteristically rapid growth rate and altered …
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Therapeutic Potential of Protein Kinases and Their Downstream Targets Following Traumatic Cervical Spinal Cord Injury
… a clinically approved protein kinase inhibitor—midostaurin—to alleviate secondary pathogenesis. While the results showed great promise, more targeted strategies would be necessary to minimize off-target effects and enhance effectiveness. Hence, gene therapy was used to modulate a downstream …
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Doxorubicin combined with phytochemicals as pro-apoptotic agents and protein kinase inhibitors for the treatment of acute myeloid leukaemia
… in clinical trials leading to the approval of Midostaurin for the treatment of AML. However, drug resistance and kinase selectivity are still challenges faced by current FLT3 inhibitors. The aim of this study was to investigate in vitro, the anti-leukaemic effect of phytochemicals that are …