Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"middle-aged rats"”.
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THE EFFECT OF MELATONIN IN PROTECTING AGAINST THE BEHAVIORAL CONSEQUENCES OF CHRONIC HYPOPERFUSION IN MIDDLE-AGED FEMALE RATS
… use of the 2-vessel occlusion (2VO) procedure in rats, which limits cerebral blood flow (CBF) through bilateral arterial ligation. Therefore, the current study investigated whether chronic melatonin would attenuate 2VO induced behavioral deficits in middle-aged female rats. Thirty 9- to …
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Non-proteolytic roles of the ubiquitin-proteasome system in memory formation across the lifespan
… of K63 polyubiquitination in the hippocampus of aged male rats reversed contextual fear memory impairments, whereas similar manipulations in middle-aged rats with normal memory had no effect, highlighting the age-specific role of K63 polyubiquitination in memory. Conversely, the amygdala …
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Estrogenic modulation of place and response learning via specific receptor-mediated mechanisms
… on the cognitive task and neural systems engaged. Estrogens generally enhance learning and memory for tasks that are sensitive to function of the hippocampus but impair the performance of tasks that tap the dorsal striatum. These memory systems do not act in isolation but rather appear to …
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The role of Igf2 methylation and histone ubiquitination in age-related memory decline
… Administration of IGF2 to the hippocampus of aged animals has been shown to improve memory, and decreased levels of IGF2 have been detected in AD patients. However, whether changes in epigenetic regulation of this gene contribute to age-related memory decline is yet to be explored. There are …