Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 31 for “"middle cerebral artery occlusion"”.
-
Evaluating Longitudinal Motor Recovery in Non-Human Primates after Middle Cerebral Artery Occlusion
… sensorimotor recovery of NHPs following Middle Cerebral Artery Occlusion (MCAO) by assessing performance with both NHPSS and Kinarm. Additionally, magnetic resonance imaging (MRI) will be used to confirm stroke morphology, and volume, and examine its relationship with functional recovery. …
-
Comparison of transplantation modality of human mesenchymal stem cells expressing neurogenin1 in rat middle cerebral artery occlusion model: intra-arterial vs. intra-cerebral
… progression. In our previous study, intra-cerebral transplantation of neurogenin1-expressing MSCs (MSCs/Ngn1) in the animal stroke model dramatically improved neurologic deficits compared with the parental MSCs. However, intra-cerebral transplantation is an invasive method and inappropriate …
-
Role of Cofilin, an Actin Cytoskeletal Protein, in Ischemic Conditions: Potential Therapeutic Target for Ischemic Stroke
Cerebral ischemia or stroke is a condition associated with decreased blood supply to brain leading to death of neurons. It is associated with a diverse cascade of responses involving both degenerative and regenerative mechanisms. Actin cytoskeleton changes play a key role in mediating these …
-
Efficacy of using robotics to characterize impaired upper-limb function in a non-human primate model of stroke
… macaques through transient 90-minute right middle cerebral artery occlusion. At 2.5 years post-stroke, neurobehavioural outcomes were assessed using a visually guided reaching (VGR) and a postural perturbation (PP) KINARM exoskeleton robotic task. Stroke NHP task parameters were compared to …
-
Mathematical Models of Major Arterial Occlusion
The occlusion of a major artery constitutes a serious health concern as it can restrict blood flow and oxygen transport to dependent tissue regions. Fortunately, the vasculature surrounding the occlusion has mechanisms by which it can adapt to try to restore and maintain adequate perfusion to these …
-
The Effects of Onion and Yuzu Extracts against Ischemia/Hypoxia-Induced Dysfunction of Blood-Brain Barrier
… during ischemia/hypoxia using the mouse middle cerebral artery occlusion (MCAO) model and hypoxia model. The possible underlying mechanisms are also investigated, especially those linked to the oxidative stresses. Onion extract (OE) and its major component, quercetin (Quer), as well as …
-
Therapeutic Targeting of Arteriogenesis Following Ischemic Stroke
… connections between distant arterioles of cerebral arteries. Under healthy conditions, these vessels are exposed to bidirectional blood flow, keeping them small and dormant. Following vascular obstruction, pial collaterals are exposed to unidirectional blood flow, triggering them to expand …
-
Unraveling the Role of EphA4 in Immune-Mediated Arteriogenesis After Ischemic Stroke
… resulting from ischemic events often caused by occlusion of the middle cerebral artery (MCA). Pre-existing leptomeningeal collateral (LMC) vessels connect MCA branches to anterior or posterior arteries, situated along the brain's cortical surface or meninges, under healthy conditions these …
-
Neurochemical Changes Following Stroke: Role In Neuroprotection And Cardiac Susceptibility
… enzyme, tyrosine hydroxylase (TH), following middle cerebral artery occlusion (MCAO) in adult male Wistar rats.;Five days following MCAO, the immunoreactivity for TH and neuropeptide Y (NPY) increased in the insular cortex (IC) within the peri-infarct zone. NPY also increased ipsilaterally in …
-
An investigation of the neuroprotective properties of fenamate NSAIDs, against experimental model of ischemic stroke
… in understanding the underlying pathogenesis of cerebral ischemia support the involvement of multiple biochemical pathways in the development of the ischemic injury.</p> <p>The work reported in this thesis was undertaken to investigate the hypothesis that fenamate NSAIDs have neuroprotective …
-
The role of mast cells in a mouse model of focal cerebral ischaemia
… mast cell deficiency prior to onset of transient middle cerebral artery occlusion (tMCAo) in rats resulted in a significant reduction in blood brain barrier (BBB) permeability, oedema and neutrophil recruitment. Therefore the hypothesis of this thesis was that mast cells are active in the acute …
-
Novel Protective Agents against Cerebral Ischemia/Reperfusion Injury.
… toxicity, exhibited anti-apoptotic properties on cerebral ischemia injury. HNG reduced infarct volume after ischemia/reperfusion injury with pre-treatment or post-treatment (i.c.v. and i.p.) in a middle cerebral artery occlusion model in mice and decreased neurological deficits induced by …
-
Investigating white matter alterations and secondary neurodegeneration with MRI imaging and pathology in a mouse model of ischaemic stroke
… like the corpus callosum and thalamus after a middle cerebral artery stroke may contribute to cognitive decline. The aim of the current study was to examine remote grey and white matter alterations in anatomically connected brain regions following experimental cortical ischaemic stroke, with a …
-
Gelatin nanoparticles for improved neuroprotection of intranasally delivered osteopontin in ischemic stroke
… administered OPN peptide to at least 6 h post-middle cerebral artery occlusion (MCAO). Our findings support the development of GNPs as a promising drug delivery platform for the intranasal treatment of ischemic stroke and, potentially, other neurologic disorders.
-
Development of intranasal therapeutic nanoparticles for the treatment of neurological disorders
… model drugs when administered up to 6 h after middle cerebral artery occlusion (MCAO) in a rat model. The specific properties of intranasal GNPs that confer these beneficial effects are poorly understood. Therefore, we sought to support the development of GNPs as a drug delivery platform for …
-
Deficits in Auditory, Cognitive, and Motor Processing Following Reversible MCAO in Mice: Understanding the Human Stroke Phenotype
… and/or bodily function resulting from a cerebral vascular accident (interruption of blood flow to the brain). Acute ischemic stroke is the third leading cause of death in the United States, and the leading cause of long-term functional disability in adults. Stroke-induced deficits may …
-
Targeting autophagy for improving stem cell function in brain repair
… after experimental stroke using a mouse model of middle cerebral artery occlusion (MCAO). Animals were split into 3 transplantation groups: vehicle control; MHP/shRNA Scramble control; and MHP/Atg7-KD; and stem cell functionality in the ischaemic brain was measured using functional behavioural …
-
Developing an adjunct therapy to mechanical thrombectomy in a murine model of stroke ischaemia reperfusion injury
… adjunct therapy to MT using the murine transient middle cerebral artery occlusion model (tMCAO). In this thesis, I have adapted the tMCAO to allow local drug administration during reperfusion via an intra-arterial polyimide-based microcatheter. I show that this novel model with the intra-arterial …
-
Optical-Resolution Photoacoustic Microscopy
… changes of cortical vasculature in a transient middle cerebral artery occlusion mouse model. I also explore the potential of OR-PAM for transcranial monitoring of amyloid plaque growth in an AD mouse model.
-
INVESTIGATION OF GENETIC FACTORS DETERMINING ISCHEMIC STROKE OUTCOME
… to use a surgically induced, permanent, focal cerebral ischemic stroke mouse model to investigate genetic factors of ischemic stroke outcome measured by infarct volume. This model is the middle cerebral artery occlusion (MCAO) model. First, we screened infarct volumes across 32 inbred mouse …
Page 1 of 2