Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 66 for “"middle cerebral artery"”.
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Evaluating Longitudinal Motor Recovery in Non-Human Primates after Middle Cerebral Artery Occlusion
… sensorimotor recovery of NHPs following Middle Cerebral Artery Occlusion (MCAO) by assessing performance with both NHPSS and Kinarm. Additionally, magnetic resonance imaging (MRI) will be used to confirm stroke morphology, and volume, and examine its relationship with functional recovery. …
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Doppler ultrasound technique used to determine the blood flow viscosity in the middle cerebral artery of a canine animal model
The cerebral blood flow velocity in the middle cerebral artery of an canine animal model was measured using the Doppler Ultrasound technique. A transducer was designed with a 20 MHz piezoelectric crystal and used for the application. An in vitro calibration system was designed and machined for the …
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Comparison of transplantation modality of human mesenchymal stem cells expressing neurogenin1 in rat middle cerebral artery occlusion model: intra-arterial vs. intra-cerebral
… progression. In our previous study, intra-cerebral transplantation of neurogenin1-expressing MSCs (MSCs/Ngn1) in the animal stroke model dramatically improved neurologic deficits compared with the parental MSCs. However, intra-cerebral transplantation is an invasive method and inappropriate …
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Unraveling the Role of EphA4 in Immune-Mediated Arteriogenesis After Ischemic Stroke
… ischemic events often caused by occlusion of the middle cerebral artery (MCA). Pre-existing leptomeningeal collateral (LMC) vessels connect MCA branches to anterior or posterior arteries, situated along the brain's cortical surface or meninges, under healthy conditions these vessels remain dormant …
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Investigating white matter alterations and secondary neurodegeneration with MRI imaging and pathology in a mouse model of ischaemic stroke
… like the corpus callosum and thalamus after a middle cerebral artery stroke may contribute to cognitive decline. The aim of the current study was to examine remote grey and white matter alterations in anatomically connected brain regions following experimental cortical ischaemic stroke, with a …
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CHOLESTEROL INDUCED GENE EXPRESSION CHANGES IN THE BRAIN AND CEREBRAL VESSELS
… on gene expression changes in the brain and cerebral vessels, which may contribute to these disorders. Present findings showed that cholesterol exerted different acute and chronic effects on gene expression in both regions. Acute intracortical administration of oxysterols at low concentration …
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Role of Cofilin, an Actin Cytoskeletal Protein, in Ischemic Conditions: Potential Therapeutic Target for Ischemic Stroke
Cerebral ischemia or stroke is a condition associated with decreased blood supply to brain leading to death of neurons. It is associated with a diverse cascade of responses involving both degenerative and regenerative mechanisms. Actin cytoskeleton changes play a key role in mediating these …
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Effects of Cerebral Blood Flow and Temperature on Executive Function During Moderate Hyperthermia
… heat stress may be affected by changes in cerebral blood flow (CBF) as opposed to thermal perception changes. An end-tidal forcing system was used to maintain eucapnia and baseline CBF in the isocapnic trial during the hypocapnia-induced CBF reduction. Repeated measures analysis of variance …
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An electronically steered, wearable transcranial doppler ultrasound system
… Doppler (TCD) ultrasound system to measure cerebral blood flow velocity (CBFV) at the middle cerebral artery (MCA). TCD sonography has been clinically indicated in a variety of neurovascular diagnostic applications. Acceptance of conventional TCD methods, however, has been primarily impeded …
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The Effects of Dendro[60]Fullerene on Neurobehavioral Outcome and Cerebral Vascular Function After Traumatic Brain Injury
… in reactive oxygen species (ROS) that leads to cerebral vascular dysfunction. The reduction of ROS can preserve vascular function and lead to improved outcomes. The antioxidant carboxyfullerene nanoparticle, dendro[60]fullerene (DF-1) was examined as a potential therapy for TBI because of its …
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Importance of MAPK and PKC in cerebrovascular endothelin receptor changes
… of contractile ETB receptors in the ipsilateral middle cerebral artery (MCA) after experimental focal ischemia and a similar upregulation is also seen after organ culture of MCA. Furthermore, studies have shown an involvement of protein kinase C (PKC) and extracellular signal-regulated kinases …
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Effect of Isoflurane Post-treatment on tPA-exaggerated Brain Injury in a Rat Ischemic Stroke Model
… post-treatment on intracranial hemorrhage and cerebral infarction after tPA treatment for transient cerebral ischemia. Cerebral ischemia was modeled in male Sprague-Dawley rats (n = 32) by occluding the right middle cerebral artery for 1 hour (h), followed by intravenous tPA administration. …
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The Expression Profile of A Gwas Detected Gene (Ninj2) In The Brain of A Mouse Model of Ischemic Stroke
… a time-course from a transiently induced middle cerebral artery ischemic stroke in mice brains. We report an increase in the gene expression of NINJ2 in the ischemic and peri-infarct (ipsilateral) cortical tissues at 7 and 14-days after stroke. We also report an increase in the protein …
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Effect of head elevation on intracranial blood flow velocity following acute ischemic stroke
… effect of 30, 15, and 0 degree HOB elevation on middle cerebral artery (MCA) mean flow velocity (MFV) in a convenience sample of 20 patients presenting with acute ischemic stroke. Transcranial Doppler (TCD) sonography mounted by head frame was used to measure MCA MFV. Patients were on average …
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Brain activation following constraint-induced movement therapy using functional near infrared spectroscopy in stroke patients
… who experienced hemiparesis after a left middle cerebral artery (MCA) stroke. Participants’ upper extremity motor functioning following two weeks of CIMT was examined to determine if CIMT during stroke rehabilitation is associated with changes in neural activity.
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Efficacy of using robotics to characterize impaired upper-limb function in a non-human primate model of stroke
… macaques through transient 90-minute right middle cerebral artery occlusion. At 2.5 years post-stroke, neurobehavioural outcomes were assessed using a visually guided reaching (VGR) and a postural perturbation (PP) KINARM exoskeleton robotic task. Stroke NHP task parameters were compared to …
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The effect of sedentary behaviour on cardiovascular biomarkers in active, healthy adults
… ultrasound assessment of brachial and femoral artery flow-mediated dilation (FMD) and carotid artery intima-media thickness was conducted. Carotid-femoral pulse wave velocity and middle cerebral artery blood flow velocity were assessed via applanation tonometry and transcranial Doppler …
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Vascular receptor changes in ischemic stroke
… vascular endothelin and angiotensin systems in cerebral arteries. To study vascular receptor changes in ischemic stroke transient focal ischemia was induced in rats. In addition, rat cerebral arteries and arterial smooth muscle cells were cultured for further analysis of cerebrovascular receptor …
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Mathematical Models of Major Arterial Occlusion
The occlusion of a major artery constitutes a serious health concern as it can restrict blood flow and oxygen transport to dependent tissue regions. Fortunately, the vasculature surrounding the occlusion has mechanisms by which it can adapt to try to restore and maintain adequate perfusion to these …
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The Effects of Onion and Yuzu Extracts against Ischemia/Hypoxia-Induced Dysfunction of Blood-Brain Barrier
… during ischemia/hypoxia using the mouse middle cerebral artery occlusion (MCAO) model and hypoxia model. The possible underlying mechanisms are also investigated, especially those linked to the oxidative stresses. Onion extract (OE) and its major component, quercetin (Quer), as well as …
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