Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"midbrain-hindbrain boundary"”.
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Neuromeric organization of the midbrain-hindbrain boundary region in zebrafish
… compartments. The units of the vertebrate hindbrain, the rhombomeres, serve as the best-studied examples of neuromeres. Here, the lineage restriction mechanism has been found to function on the basis of differentially expressed adhesion molecules. To date, hard evidence for the existence of …
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Mechanism of cell adhesion at the midbrain-hindbrain neural plate in the teleost Danio rerio
… or eventually death of the organism. The midbrain-hindbrain boundary (also termed isthmic organizer) is a region of high interest as well in early as also in later development. The isthmic region carries organizer identity by the expression and subsequent release of FGF8. False patterning …
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Development of the Mesencephalic Trigeminal Nucleus in the Zebrafish
… numbers, suggesting that Fgf signalling from the midbrain/hindbrain boundary inhibits development of the MTN in the midbrain. When the Wnt pathway was up-regulated there was also an increase in MTN neuron number. Based on the results from these experiments a model is proposed, in which Fgf …
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Basal constriction : shaping the vertebrate brain
… bend in the vertebrate neural tube, the midbrain-hindbrain boundary constriction (MHBC). The MHBC forms between 17 and 24 hours post fertilization in zebrafish, concomitant with, but independent of ventricle inflation. Cells shorten to 75% the length of the surrounding cells prior to …
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The formation and function of the brain ventricular system
… in the embryonic zebrafish. We found that the midbrain-hindbrain boundary acts as a barrier preventing CSF movement between the midbrain and hindbrain, while CSF moves freely between the midbrain and forebrain. Additionally, the heartbeat contributes to CSF movement increasing mixing between …
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The role of pou2/spiel-ohne-grenzen (spg) in brain and endoderm development of the zebrafish, Danio rerio
… a distinct part of the embryonic brain called midbrain-hindbrain boundary (MHB), a region that acts as an organizer for the adjacent brain regions, is established in vertebrates. spiel-ohne-grenzen (spg) is one mutant which interferes with MHB development. Here, I addressed the role of pou2 in …
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Temporal and spatial controls of cell fate specification in the cerebellum
… from two adjacent organising centres, the midbrain-hindbrain boundary (isthmus) and the roof plate of the fourth ventricle. Two major precursor pools give rise to all the cells of the cerebellum: the ventricular zone and the cerebellar rhombic lip. The rhombic lip comprises a dorsal …
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Identification and characterisation of novel zebrafish brain development mutants obtained by large-scale forward mutagenesis screening
… defective in development and function of the midbrain-hindbrain boundary (MHB), an organiser region that patterns the adjacent brain regions of the midbrain and the hindbrain. In the first screen, I could identify 10 specific mutants based on morphology and the analysis of the expression …
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Co-factors of LIM-HD transcription factors in neural development and axon pathfinding in zebrafish
… in vivo and impairs the formation of eyes and midbrain-hindbrain boundary. In addition, SSDP1b knock down impairs trigeminal and Rohon-Beard sensory axon growth. N-SSDP1 can partially rescue the inhibition of axon growth induced by DN-CLIM. These results reveal specific functions of SSDP1 in …
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Multi-omics characterisation of mouse gastrulation and organogenesis at single-cell resolution
… coherence of cell types, the emergence of the midbrain-hindbrain boundary and gut tube organogenesis. Strikingly, we demonstrated that the spatial patterning of the gut tube is associated with distinct organ primordia. The spatial atlas uncovers axes of resolution that cannot be reconstructed …
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Patterning of the embryonic vertebrate Brain in Response to Fibroblast Growth Factor Signaling
… two regions of the brain, the forebrain and the midbrain-hindbrain region, affecting cellular processes as diverse as cell proliferation, differentiation, and axonal targeting. The goal of this study was to better understand the mechanisms by which Fgf signaling regulates pattern formation and …