Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"midbrain dopaminergic neurons"”.
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Identification and characterization of genes expressed by the midbrain dopaminergic neurons
The midbrain dopaminergic (mDA) neurons are the main source of dopamine in the brain. The goal of this study was to identify and characterize genes effective during the intermediate period between induction and full differentiation of the mDA neurons. The generation of En chimeric animals permitted …
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Generation of midbrain dopaminergic neurons in vivo and in vitro: the role of Neurogenin2
… (PD) is a neurodegenerative disorder where dopaminergic neurons of the substantia nigra (SNc) in the mesencephalon are progressively eliminated. The ensuing loss of dopaminergic innervation of the basal ganglia manifests itself as severe motor deficits in PD patients. Clinical trials have …
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Towards cell replacement therapy in Parkinson’s disease. Proteoglycans and Nogo-A as modulators of axonal growth in midbrain dopaminergic neurons
… This is caused by progressive degeneration of dopaminergic neurons (DNs) in the midbrain (substantia nigra pars compacta), which innervate the striatum. Although initially efficacious, the therapeutic effect of various anti-parkinsonian pharmacological treatments is limited to five to ten …
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Role of basic fibroblast growth factor in the development of sensitization to the effects of amphetamine
… in its effects on locomotor activity, reward and dopaminergic function. The precise mechanisms responsible for this persistent drug-induced sensitization are unknown, but evidence suggests that neuroadaptations initiated in the cell body region of midbrain dopaminergic neurons and dependent on …
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Effect of Parkinson’s disease-related alpha-synuclein abnormalities on the maturation of distinct iPSC-derived neuronal populations
… of Lewy pathology and the degeneration of the midbrain dopaminergic neurons from the substantia nigra pars compacta. Lewy pathology mainly consists of filamentous aggregated alpha-synuclein and familial forms of PD can be caused by genetic alternations in the SNCA gene encoding alpha-synuclein. …
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The role of the dopaminergic neurotrophin growth/differentiation factor-5 in the developing rat ventral midbrain
… been shown to be a trophic factor for embryonic midbrain dopaminergic neurons in vitro (Krieglstein et al. 1995) and after transplantation to adult rats in vivo (Sullivan et al. 1998). GDF-5 has also been shown to have neuroprotective and neurorestorative effects on adult dopaminergic neurons in …
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Investigating Parkinson’s Disease human iPSC-derived models through single-cell gene expression
… Directed differentiation protocols of iPSC to midbrain dopaminergic neurons enables the study human midbrain Dopamine(DA) neurons, the primary neuronal group affected in Parkinson's Disease(PD), in-vitro. Despite their increasing adoption and disease modeling potential in neuroscience research, …
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Development of single-molecules techniques to study native α-Synuclein aggregates
… The iPS cells were differentiated into midbrain dopaminergic neurons, the primary neuronal subtype associated with the pathogensis of PD and the conditioned media was collected and used as an analogue of cerebrospinal fluid. Initial, investigations focused on utilising amyloid binding …