Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 31 for “"microvesicles"”.
-
The role of microvesicles in cancer and viral infection
Microvesicles are shed constitutively, or upon activation from both normal and malignant cells. Although recent studies have reported various nonlytic virus release mechanisms, this mode of virus transmission to secondary sites of infection has remained unclear. This study identified that Coxsackie …
-
The role of microvesicles in EMT and tumour microenvironment
Microvesicles are heterogeneous population of micro-particles released constitutively and upon induction from healthy and unhealthy cells. The role of cancer cell derived-MV in intercellular communication gains an intensive aria of research. The influence of leukaemia cell derived-MVs in this study …
-
The role of prostate cancer microvesicles in epithelial mesenchymal transition
Microvesicles (MVs) are shed to the extracellular environment upon activation by both normal and diseased cells. Increasing evidence has shown that cancer cellderived MVs carry pathogenic components, such as proteins, messenger RNAs, microRNAs, long non-coding RNAs, DNAs, lipids, and …
-
Erythrocytes derived microvesicles : their characterisation and potential role as delivery vectors
… depending on their biogenesis and size. Microvesicles (MV) are a subtype of EV and are released under optimal cell conditions and/or upon stimuli. In this study, the influence of erythrocyte derived MV (eMV) on the growth of THP-1 and Jurkat cell lines was observed. HeLa cells and those …
-
The role of PADs in the biogenesis of prostate cancer microvesicles which play a dysfunctional role on DC biology and the therapeutic potential of skeletal muscle microvesicles on prostate cancer cells
Microvesicles (MVs) are small, plasma membrane derived vesicles that are shed constitutively or upon activation from both normal and malignant cells. Apart from physiological roles, MVs have also been implicated to play a role in various pathologies particularly cancer. Aspects of MV biogenesis and …
-
HOW MICROVESICLES ARE "BUDDING" INTO THE CANCER CONVERSATION: THE ROLE OF GLYCOCALYX-INDUCED MEMBRANE BENDING
… contribute to tumor progression and metastases. Microvesicles, a specific EV subtype, directly shed from the plasma membrane, but how this occurs is not fully elucidated. To help address this, there is a need for consistent convention and methodology to clearly differentiate and fully …
-
Mechanistic Studies On the Role of Polyamines and Microvesicles in Tumor Growth and Hypoxia-mediated Angiogenesis
… mechanistic roles of polyamines and microvesicles in tumor biology and hypoxia-mediated angiogenesis. We considered the option of inhibiting cancer cell proliferation by the combination of polyamine synthesis inhibition with phage display-derived antibodies targeting the polyamine …
-
On the Role of Polyamines and Microvesicles in Tumour Development. Regulation by Hypoxia and Implications for Therapeutic Intervention of Cancer.
… regulation of polyamines and tumour cell-derived microvesicles (MVs), both of which have been associated with tumour development. It was initially demonstrated that epitope-specific interference of cell surface heparan sulphate proteoglycans (HSPGs) by anti-HS antibodies inhibits the …
-
Development of novel isolation methodologies for microvesicles and exosomes, as potential biomarkers for health (Therapeutic Lifestyle Changes), and use of microvesicle-delivered β-Gly in erythroleukaemia
Both MVs and exosomes are isolated by similar methodologies such as differential centrifugation of cell culture supernatant (S/N), filtration, floating on chemical gradients or using antibody labelled magnetic beads. Hence, the isolation techniques, commonly in use, provide low levels of …
-
Host modulation of excessive innate immune responses
… thesis describes a novel defense mechanism of microvesicles against the gram-positive bacterium Streptococcus pyogenes. We show that procoagulant microvesicles are released after stimulation of pheripheral blood mononuclear cells with M1 protein from S. pyogenes. These microvesicles bind to the …
-
The Influence of Membrane Lipid Order on Cell Shape and Microvesiculation in Human Erythrocytes
… shedding of the cell membrane in the form of microvesicles. We hypothesized that both the shape transition and microvesiculation are influenced by microscopic membrane physical properties such as lipid order. To test this hypothesis, membrane properties were manipulated by varying the …
-
Biochemical and physiological analysis of microvesicle subtypes
… of extracellular vesicles: in particular microvesicles (MVs). The characterisation utilised novel applications of existing protocols, demonstrated for the first time within this thesis, resulting in an up-to-date and greatly improved series of techniques for the analysis of microvesicles. …
-
Role of vascular remodeling in the accumulation, clearance, and biodistribution of biomolecular factors in melanoma
… including cytokines, exosomes, proteases, and microvesicles, mediate pathological signaling and have emerged as putative therapeutic targets. However, SF bioavailability in distributed tissues and the impact of disease progression on their dissemination profiles and exposure to various immune …
-
Cellular Trafficking of Single and Multistage Vectors
… stage nanoparticles were found to be secreted in microvesicles which can act as mediators of transfer of particles across the endothelium and between different endothelial and cancer cells.</p>
-
Exosome-Mediated Protection Against Oxidative Stress: A Connection Between NRF2 And Exosomes
… into exosomes [1]. Exosomes are extracellular microvesicles that are secreted by cells in response to a variety of stimuli, including many stressors. Exosomes serve as a transport mechanism for proteins, RNA, DNA, and other molecules. Therefore, we hypothesized that exosome loading and release …
-
Gene Delivery to the Blood-Brain Barrier for Ischemic Stroke Therapy
… / Pluronic P84 (P84) and exosomes (EXOs) / microvesicles (MVs)) to deliver brain-derived neurotrophic factor (BDNF) plasmid DNA (pDNA), a functional gene encoding a neurotrophin. In the first project, our data showed that DNA nanoparticles (NPs) with 0.03% P84 was a promising formulation to …
-
Impact of human blood plasma-derived protein corona on extracellular vesicle uptake
… Exosomes (EXOs), ca 50-100 nm in diameter and microvesicles (MVs), ca 100-1000 nm in diameter, having different intracellular origin, are the two main subpopulations of EVs. EVs have been demonstrated to carry a range of proteins and nucleic acids subsequently delivered to recipient cells, …
-
New Types of Morpho-Physiological Changes in Cells Exposed to Nanosecond Pulsed Electric Field
… cell permeabilization to induce staining of microvesicles and pseudopod-like blebs (PLB). The results show that microvesiculation develops in HL60 and U937 cells in response to Ca<sup>2+</sup> presence during nsPEF exposure. Microvesiculation does not depend on colloid-osmotic swelling (COS). …
-
Tissue Transglutaminase And Its Role In Human Cancer Progression
… and intermediate filament protein keratin-19. Microvesicles (MVs) derived from human cancer cells are receiving a good deal of attention because of their ability to participate in the transfer of signaling proteins between cancer cells and to contribute to their invasive activity. Here I show …
-
Nonlinear optical microscopy and spectroscopy by pulse shaping of a coherent fiber supercontinuum
… lipid degradation, and distribution of microvesicles are identified and correlated by multimodal imaging. The proposed technology presents simplicity and applicability, and may have a broader impact in biomedical research and fundamental science.
Page 1 of 2