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Showing 1 to 20 of 112 for “"microvasculature"”.
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Engineered, functional, human microvasculature in a perfusable fluidic device
… for the generation of functional, human, microvasculature. Using different fabrication methods, we developed both a micro-fluidic system (0.1 - 1 mm tissue dimensions) - used for high throughput disease modeling assays, and a meso-fluidic system (I - 10 mm tissue dimensions) - for …
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Computational Modeling of Intracapillary Bacteria Transport in Tumor Microvasculature
The delivery of drugs into solid tumors is not trivial due to obstructions in the tumor microenvironment. Innovative drug delivery vehicles are currently being designed to overcome this challenge. In this research, computational fluid dynamics (CFD) simulations were used to evaluate the behavior of …
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Signaling Induced by Inflammatory Mediators in the Rodent Pulmonary Microvasculature
<p>Acute lung inflammation (ALI), stemming from a disproportionate and detrimental immune response, may arise from or complicate other disease states, leading to the often-fatal acute respiratory distress syndrome (ARDS). Because of the many culpable factors and differing points of induction, …
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Engineered microvasculature platforms to study tumor-host-matrix interactions during metastatic seeding
Distant metastases, which result in >90% of cancer related deaths, is enabled by hematogenous dissemination of tumor cells via the circulation. In particular, tumor cell extravasation is thought to be an essential and potential rate-limiting step, as most metastases are found in the extravascular …
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On-Chip Engineered Human Lymphatic Microvasculature for Physio-/Pathological Transport Phenomena Studies
… these limitations, we developed a 3D lymphatic microvasculature model, that physiologically emulates the lymphatic structure and function, within a microfluidic system that allows for high spatial-temporal control over the biological transport phenomena to study cellular events. For the first …
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Impacts of Empagliflozin (EMPA) Treatment on Skeletal Muscle Microvasculature in Type 1 Diabetic Rats
… empagliflozin (EMPA), has any impact on the microvasculature in SM. T1D was induced in eight-week-old male rats using streptozotocin (65 mg/kg, n=21). Twenty-one rats were given daily insulin and 11 of 21 rats also consumed EMPA (30 mg/kg/day) for 14 days. Twelve healthy non-diabetic rats …
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The retinal microvasculature as an early indicator of chronic disease risk in older populations
It has previously been suggested that the measurement of retinal blood vessel parameters could provide an increased understanding of chronic systemic diseases with a vascular component. This easy, non-invasive imaging modality provides an indication of microvascular health that may reflect ongoing …
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Assessment of Morphology and Hemodynamics in Normal and Remodeled Microvasculature with Parameter Sensitivity Analysis
The goal of this study was to compare the morphological and hemodynamic characteristics of normal and remodeled vascular networks in the mouse gracilis muscle. To this end, previously developed models to assess flows and vascular branching were used to assess the normal and remodeled …
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The Influence of Dietary Fat on The Cerebral Microvasculature: Compositional, Prostaglandin Synthetic, and Permeability Studies
… phenomena in the cerebral cortex and microvasculature the following studies were conducted. Rats fed purified diets containing 10% corn, hydrogenated coconut, or linseed oils through two generations were sacrificed and the following items measured: fatty acyl composition of …
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Mapping Anisotropic Tissue Fiber and Microvasculature Architecture With Diffusion MRI: Application to Skeletal Muscle and White Matter
… characterization of anisotropic tissue fiber and microvasculature architecture in vivo, and their tissue-specific implementation in two areas of particular radiological interest: the skeletal muscle in the calf and the white matter in the brain. At the MR spatial encoding level, imaging techniques …
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Integrated Multimodal Analysis: Evaluating the Impacts of Chemotherapy and Electroporation-Based Therapy on Lymphatic and Blood Microvasculature in Cancer
… tumor cells, affect the lymphatic and blood microvasculature in the tumor, surrounding fat pad, tumor draining lymph node (TDLN) using multiple analysis methods. This occurred through three main methods 1) identification of oxidative stress effects of chemotherapeutic application of …
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Endothelial dysfunction in rheumatoid arthritis: the role of inflammation and classical cardiovascular disease risk factors on the microvasculature and the macrovasculature
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease of the joints with predominant symptoms of pain, swelling and stiffness. Patients with RA are at increased risk of cardiovascular disease (CVD). The exact mechanism for this is unknown, but RA disease-related inflammation has been …
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MICRO-CT EVALUATION OF MSC/HUVEC/HSC-MEDIATED ANGIOGENESIS IN LARGE PCL-ßTCP CONSTRUCTS IMPLANTED IN NUDE MICE
… tomography (micro- CT). The formation of microvasculature was significantly higher in the MSC-HUVEC and MSC-HSC constructs than those seeded with MSC alone or cell-free constructs. Volumetric analysis showed that MSC-HUVEC constructs contained 250% more microvasculature than cell-free …
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Fabrication of tissue scaffolds using projection micro-stereolithography
… features of the in vivo liver is the extensive microvasculature which allows for the delivery of nutrients and metabolites without exposing hepatocytes to de-differentiating fluidic shear stresses. A new liver tissue scaffold design able to capture this histological organization may therefore …
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THE VASCULAR RESPONSE WITHIN THE ISLET DURING BETA CELL DEVELOPMENT AND REGENERATION
… performed to observe the ontogeny of changes to microvasculature, endocrine tissue, and growth factors over the subsequent 40 days. Normal islet development involved remodelling of the islet vasculature around weaning which may involve nestin+ cells. Destruction of β cells resulted in a …
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Changes in microvascular hematocrit during post-occlusive reactive hyperemia: descriptions and mechanisms
… in red blood cell concentration in the microvasculature, i.e., microvascular hematocrit. In Chapter 4 comparisons were made between brachial artery blood flow, cutaneous and skeletal muscle flux and T[Hb+Mb]. The conduit artery response was faster than the microvascular responses in all …
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Neutrophil biomechanical properties and immune function in health and inflammatory disease
… to neutrophil trafficking, a novel microfluidic microvasculature mimetic was developed. An endothelial flow assay was used to image neutrophils interacting with endothelial cells. Finally, the complete proteomes and phosphoproteomes of LDGs and normal dense neutrophils (NDNs) were obtained from …
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Design and potential clinical impact of a noninvasive thermal diffusion sensor to monitor human peripheral microvascular perfusion in real-time
… assessments of the human microcirculation. Human microvasculature includes the arterioles, capillaries, and venules that supply tissues with nutrients, circulate humoral products, and remove waste. The process of circulatory distribution is an efficient and highly structured process that …
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