Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"microvascular networks"”.
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Direct ink writing of microvascular networks
Nature is replete with examples of embedded microvascular systems that enable efficient fluid flow and distribution for autonomic healing, cooling, and energy harvesting. The ability to incorporate microvascular networks in functional materials systems is therefore both scientifically and …
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Embedded microvascular networks for electronically reconfigurable materials
Microvascular networks in biological systems carry out various functions, such as damage repair, temperature regulation, and nutrient transport. Biological vasculature has inspired the use of microfluidic networks in various synthetic materials to achieve similar functionality such as …
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Microvascular Networks for Continuous Self -Healing Materials
… events in a continuous self-healing coating on a microvascular substrate. A three-dimensional, interconnected microvascular network in the substrate serves as a delivery system for healing materials to heal damage in a polymer coating. Two approaches to microvascular delivery are explored: one …
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Directed Assembly of Three-Dimensional Microvascular Networks
The construction of 3-D microvascular networks enables microfluidic devices with unparallel geometric complexity. In one example, a 3-D microfluidic mixing device was demonstrated with square-spiral mixing towers isolated within the vascular network by a secondary photopatterning process. These …
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Nonlinear dynamics of blood flow in simple microvascular networks
… hematocrit, and blood velocity can occur in microvascular networks in the absence of biological control. In this paper, both analytical and numerical methods have been used to investigate the nonlinear dynamics of microvascular blood flow in simple networks. First, the steady state solutions …
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Late Effects of Ionizing Radiation on Normal Microvascular Networks
… in changes in the structure and function of microvascular networks in normal tissue. Previously, we reported on the early effects of ionizing radiation on microvascular networks at 3, 7, and 30 days post-irradiation [1-3]. Data from the early time points suggested that ionizing radiation …
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Engineered, perfusable, human microvascular networks on a microfluidic chip
… a reliable platform for engineering perfusable, microvascular networks on-demand using state of the art microfluidics technology. We have demonstrated the utility of this platform for studying cancer metastasis and as a test bed for drug discovery and analysis. In parallel, this platform enabled …
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Self-healing materials and multinozzle printheads with embedded microvascular networks
Microvascular networks are pervasive in biological systems, assisting in the repair of tissue damage, regulation of temperature, and efficient distribution of nutrients. Emulating these functional attributes in engineering contexts such as self-healing materials, microfluidic temperature …
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Rapid formation of cell-mediated microvascular networks in collagen, fibrin, and puramatrix provisional matrices
… of tissue engineering is to develop blood vessel networks to deliver oxygen and nutrients to thick, metabolically-demanding, dynamically remodeling artificial tissues. There is also extensive interest in the possibility of delivering vascular cells for therapy of ischemic diseases. To address …
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Assessment of in vitro engineered microvascular networks and their application in the treatment of chronic wounds
… have developed a method for engineering microvascular networks in vitro using various microfabrication techniques. This paper discusses the current state of the research and technical challenges to overcome before commercializing the technology. The feasibility of using the networks in …
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Self-healing laminated composites from prepreg fabrics
… for creating a self-healing material is to embed microvascular channels which can deliver healing agents from an external reservoir. These pervasive channels can transport large amounts of healing agents to fracture planes with the aid of an external pump, but segregated channels can suffer from …
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A Low-cost Microvascular Phantom for Photoacoustic Imaging Using Loofah
… are inadequate for mimicking the complex microvascular structures found in human tissue due to their inability to replicate varying sizes and distri- butions of vasculature. This limitation underscores the need for a new material capable of replicating intricate microvascular networks. In …
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Bioinspired microvascular self-healing in polymers and composites
… in solid polymer systems through in situ microvascular delivery. However, translation of these capabilities to load-bearing materials has been limited due to the delicate, sacrificial templates used to construct the inverse vasculatures. This dissertation outlines further development of in …
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Microvascular composites as a multifunctional material for electric vehicles
… accomplish this multifunctional objective using microvascular fiber-reinforced composites. Batteries are sandwiched between carbon fiber/epoxy panels containing embedded microchannels. Coolant flow enables active cooling while the composite material provides strength, stiffness, and …
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The Effect of Red Blood Cell Velocity on Oxygenation Measurements using Resonance Raman Spectroscopy
… oxygen saturation at multiple sites in selected microvascular networks. Using this system, resonance Raman spectroscopy was employed to measure hemoglobin oxygen saturation gradients in arterioles and venules of the rat mesentery in vivo. In several in vitro experimental conditions, there was a …
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In vitro study of cancer cell extravasation in microfluidic platform
… within the bone-like matrix. Next, functional microvascular networks were generated in the microfluidic system through vasculogenesis with addition of mural cells and pro-angiogenic factors to better replicate the normal physiological vasculature of the remote site for metastasis. Lastly, the …
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Multi-stage polymer systems for the autonomic regeneration of large damage volumes
… gaps up to 9 mm in diameter. The combination of microvascular networks and a new healing chemistry demonstrates an innovative healing system that significantly exceeds the performance of traditional methods.
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Microvascular materials for adaptive electronic structures
Biologically-inspired microvascular networks have found many uses in synthetic materials, including self-healing, thermal management, and electromagnetic reconfiguration. In particular, reconfigurable radio-frequency (RF) systems enabled by microvascular networks containing conductive liquids …
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MICRO-CT EVALUATION OF MSC/HUVEC/HSC-MEDIATED ANGIOGENESIS IN LARGE PCL-ßTCP CONSTRUCTS IMPLANTED IN NUDE MICE
Stable vascular networks are prerequisite for scaffold-guided reconstruction of large voluminous bony defects. However, induction of angiogenesis remains a major challenge for bone-tissue engineering. The present in vivo study evaluates human umbilical cord derived vascular endothelial cells …
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Biophysical modeling of hemodynamic-based neuroimaging techniques
… by performing Monte Carlo simulations over real microvascular networks and oxygen distributions measured in vivo on rodents, at rest and during forepaw stimulation, using two-photon microscopy. Our model reveals for the first time the specific contribution of individual vascular compartment to …
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