Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"microvascular network"”.
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Tumor cell extravasation in an in vitro microvascular network platform
… to study tumor cell extravasation from in vitro microvascular networks formed via vasculogenesis. Various techniques to yield optimal networks were assessed in order to achieve an appropriate balance between vascular growth, remodeling and stabilization. These include the application of various …
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Engineered, perfusable, human microvascular networks on a microfluidic chip
… a reliable platform for engineering perfusable, microvascular networks on-demand using state of the art microfluidics technology. We have demonstrated the utility of this platform for studying cancer metastasis and as a test bed for drug discovery and analysis. In parallel, this platform enabled …
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DESIGNER COLLAGEN-FIBRIL BIOGRAFT MATERIALS FOR TUNABLE MOLECULAR DELIVERY
… currently is the formation of a functional microvascular network as part of an engineered tissue graft. Despite many advances in tissue engineering methods, the field still awaits biograft designs that enable neovascularization at clinically relevant size scales. Critical to the design of …
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Microvascular Networks for Continuous Self -Healing Materials
… events in a continuous self-healing coating on a microvascular substrate. A three-dimensional, interconnected microvascular network in the substrate serves as a delivery system for healing materials to heal damage in a polymer coating. Two approaches to microvascular delivery are explored: one …
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Engineering functional blood vessels in vivo
… demonstrated the formation of functional microvascular network by co-implantation of human umbilical cord vein endothelial cells (HUVECs) and 10 T 1/2 cells, a line of mouse embryonic fibroblasts. To translate this concept to the clinic, we need to utilize cells that can be secured and …
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An immune-competent microvascularized human lung-on-chip device for studying immunopathologies of the lung
… lung tissue model comprises of a 3D, perfusable microvascular network underneath a mature, differentiated epithelium at an air-liquid interface. With this model, we demonstrate that a conventional lung-on-chip (LOC) that lacks immune cells induces limited cytokine response to severe influenza …
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IN-VITRO VASCULARIZED TISSUE EQUIVALENTS FROM HUMAN EMBRYONIC STEM CELL-DERIVED ENDOTHELIAL AND VASCULAR SMOOTH MUSCLE CELLS
… is the formation of functional vascular networks. Secondly, these applications require scalable production of homogeneous populations of vascular cells that include endothelial cells (ECs) and vascular smooth muscle cells (vSMCs). Human embryonic stem cells (hESCs) are virtually an …
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Mechanical characterization and self-healing in synthetic vascularized materials
… fluids throughout the material volume using a microvascular network of microchannels that serve as conduits of flow and permit fluid transport throughout the material volume, in much the same way that vascular systems transport nutrients and biochemical components throughout living organisms. …
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Signaling Induced by Inflammatory Mediators in the Rodent Pulmonary Microvasculature
… of the development of the response: increased microvascular permeability. Because of the architecture and the size of the pulmonary microvascular network, the lungs have a resident, sequestered population of leukocytes that are able to rapidly respond to injury or infection, but may also …
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Self-healing materials and multinozzle printheads with embedded microvascular networks
Microvascular networks are pervasive in biological systems, assisting in the repair of tissue damage, regulation of temperature, and efficient distribution of nutrients. Emulating these functional attributes in engineering contexts such as self-healing materials, microfluidic temperature …
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Direct ink writing of microvascular networks
Nature is replete with examples of embedded microvascular systems that enable efficient fluid flow and distribution for autonomic healing, cooling, and energy harvesting. The ability to incorporate microvascular networks in functional materials systems is therefore both scientifically and …
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Blood-brain barrier model on a microfluidic chip for the study of tumor cell extravasation
… barrier model, we designed an in vitro microvascular network platform formed via vasculogenesis, using endothelial cells derived from human induced pluripotent stem cells, primary human brain pericytes, and primary human brain astrocytes. The vasculatures formed with brain pericytes and …
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The Influence of Structure and Surface Biochemistry on Cell Function and Angiogenesis in Collagen Scaffolds
… that can be vascularised successfully. Capillary networks facilitate processes that are essential for tissue survival including the supply of nutrients to cells and waste exchange. Therefore, in order to prevent core degradation of tissue-engineered grafts, it is important to provide appropriate …
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Microvascular materials for adaptive electronic structures
Biologically-inspired microvascular networks have found many uses in synthetic materials, including self-healing, thermal management, and electromagnetic reconfiguration. In particular, reconfigurable radio-frequency (RF) systems enabled by microvascular networks containing conductive liquids …
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Late Effects of Ionizing Radiation on Normal Microvascular Networks
… in changes in the structure and function of microvascular networks in normal tissue. Previously, we reported on the early effects of ionizing radiation on microvascular networks at 3, 7, and 30 days post-irradiation [1-3]. Data from the early time points suggested that ionizing radiation …