Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"microvascular function"”.
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Microvascular Function and Remodeling Due to Chronic Changes Within the Skeletal Muscle Microenvironment
… to the microenvironment impacted the appropriate microvascular remodeling responses to alterations in flow. The skeletal muscle microenvironment was altered through manipulation of TIMP1 expression or glucocorticoid (GC) levels. Furthermore, blood flow was altered via femoral artery (FA) ligation …
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Resting Microvascular and Autonomic Function in Relation to Age and Sex Hormone Concentrations
… progesterone, testosterone and age on resting microvascular and autonomic function in younger and older males and females. Microvascular function was assessed with reactive hyperemia using the microvascular function index (MFI) technique (5mins baseline, circulatory occlusion and reperfusion) …
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Correlation Between Serum Bilirubin Level and Coronary Microvascular Integrity in Diabetic Patients
… for the relation of bilirubin level and coronary microvascular function in diabetes. This study investigates whether bilirubin can preserve coronary microvascular integrity in diabetes, by assessing thecoronary flow velocities after successful percutaneous coronary intervention (PCI). METHODS: …
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The impact of maternal obesity on vascular and metabolic function throughout pregnancy.
… Using non invasive techniques microvasular function was measured at each visit. Fasting bloods were taken. This assessment allowed us to observe microvascular function, inflammatory response, dislipidaemia and changes in fatty acid composition with advancing gestation and the degree of …
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Effects of Tea on Peripheral and Cerebral Micro- and Macrovascular Function in Humans
… the vascular endothelium. Termed endothelial dysfunction, this early marker of atherosclerosis has become a focus of interest for identifying individuals at risk of a profound cardiovascular insult, particularly arising from lifestyle choices such as physical inactivity and calorie-rich diets. …
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Vascular and Neuro-Inflammatory Modulation Following Resistance Training in Young African American and White Men
… co-morbidities. Altered vascular and autonomic function has been implicated in the pathogenesis of cardiovascular diseases in this population. We sought to examine the effect of resistance exercise training on vascular and autonomic function in young African American and white men. Several …
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Evaluation of alterations in cardiovascular structure and function in end-stage renal failure.
Background: Chronic renal dysfunction is associated with myriad alterations in cardiovascular structure and function, resulting in markedly elevated rates of cardiac and vascular morbidity and mortality. Utilising advances in cardiovascular magnetic resonance imaging (CMR), we evaluated the …
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Vascular Function in Women and Children Following a Pregnancy Complicated by Preeclampsia
… to measure postpartum and offspring vascular functional alterations associated with preeclampsia in pregnancy and to improve the accuracy and clinical applicability of laser perfusion imaging. Our studies of postpartum women reveal that those with prior severe preeclampsia display heightened …
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Effect of a polyphenol-rich diet on vascular function and other markers of cardiovascular risk
… the effect polyphenol-rich foods on vascular function tests of known prognostic significance and a range of cardiovascular endpoints in hypertensive patients. The study described in this thesis was based on the hypothesis that increasing overall polyphenol dietary intake, through increasing …
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Physiological effects of exercise in patients with peripheral vascular disease
… 2 of this thesis were to compare cutaneous microvascular function between post-surgical varicose-vein patients and age-matched healthy controls and to investigate whether or not any impairment of function is alleviated by acute and chronic lower-limb exercise. The results suggest that …
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Novel cardiovascular risk factors in childhood
… with phenotypes of atherosclerosis and systemic microvascular dysfunction (Study II-III); exposure to environmental tobacco smoke (ETS) affects heart rate variability (HRV), and whether this association is influenced by diabetes-risk HLA (Study IV). The aim of study V was to investigate in an …
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Determining whether plasma levels of KATP channels are related to vascular function
… play an important role in regulating vascular function. They are also expressed in blood but their relationship with vascular function is unknown. This study aims to investigate the previously unknown relationship between levels of KATP channels in blood and vascular function in normal healthy …
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Mineralocorticoid receptor involvement in vascular dysfunction associated with vascular injury
… recently been implicated in cardiovascular dysfunction associated vascular injury. Specifically, MR blockade has been shown to treat coronary microvascular dysfunction in obesity and has been implicated in the regulation of capillary density in ischemic conditions. The fundamental mechanisms …
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Differential effects of fatty acids on the endothelium
Background: Endothelial dysfunction is a major factor in the development of atherosclerosis, thrombosis and heart disease. Evidence suggests dietary fat composition may modify cardiovascular risk, as well as surrogate markers of cardiovascular risk such as blood pressure, arterial stiffness and …
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Nonlinear Dynamics of Microcirculation and Energy Metabolism for the Prediction of Cardiovascular Risk
… i.e. oxidative stress and endothelial dysfunction. Examples of methods used for this task are the laser Doppler flowmetry (LDF) and laser fluorescence spectroscopy (LFS), which respectively allow tracing blood flow and the amounts of the coenzyme NAD(P)H (nicotamide adenine dinucleotide) …
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Full Field Laser Perfusion Imaging and Post Occlusive Reactive Hyperaemia in the Skin Microcirculation: A Biomarker of Cardiovascular Disease Risk?
… of the skin microcirculation. Endothelial dysfunction is the earliest detectable functional indicator of cardiovascular disease (CVD), contributing to the development of atherosclerosis. Assessment of endothelial function provides a powerful method to identify patients at risk of developing …
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Insulin resistance and cardiovascular function - Observational, translational and interventional studies
Background: Microvascular disease is now recognized as an important driver for cardiovascular mortality and morbidity. Diabetic patients are known to suffer from this condition, leading to e.g. coronary ischemia as well as kidney dysfunction. Accumulating evidences indicate that the vascular …
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Endothelial NADPH oxidases as regulators of coronary microvascular dysfunction in diabetic cardiac remodeling
… describes distinct structural and functional changes in the heart driven by metabolic and microvascular abnormalities. Microvascular dysfunction appears at an early stage as a result of impaired endothelial function, at least in part due to hyperglycaemia-induced production of …
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CARDIOVASCULAR CONSEQUENCES AFTER SPINAL CORD INJURY AND THE EFFECTS OF ELECTRICAL STIMULATION
… clothing garment on macrovascular (femoral) and microvascular (skin) perfusion and oxygen consumption in people with SCI. This particular method of ES has significant clinical potential because it can be applied for longer periods and in a home based environment. Eight participants with a motor …