Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 57 for “"microtubule-associated protein"”.
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Identification and characterization of BEN1, a novel microtubule associated protein in fission yeast
… It showed that Ben1p localized to cytoplasmic microtubules. We generated ben1Δ. cells by replacing it with a copy of ura4<sup>+</sup>. We observed that 20% of the cells were undergoing division. Next we observed the effects that deleting ben1<sup>+</sup> would have on the functions of Mto1p and …
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Kidney tubulogenesis in human renal organoids: an investigation into the contribution of the microtubule-associated protein DCDC2
… demonstrate that both actin filaments and the microtubules, two major cytoskeletal systems, undergo drastic rearrangements across the MET process in kidney organoids. Both cytoskeletal systems are controlled by a large variety of regulators. Such as proteins affecting nucleation, polymerisation …
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USING B-STRAND AND B-HAIRPIN PEPTIDOMIMETICS INDUCED BY CONSTRAINED AMINO ACIDS TO MODULATE THE AGGREGATION OF THE MICROTUBULE ASSOCIATED PROTEIN TAU: DESIGN, SYNTHESIS AND EVALUATION
… by the presence of abnormal aggregates of Tau protein, leading to the formation of neurofibrillary tangles (NFTs) within neuronal cells. Tau, a protein associated with microtubules (MTs), plays a crucial role in regulating the dynamics of MTs and facilitating proper axonal transport in neurons. …
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DECIPHERING THE FUNCTION OF HURP IN REGULATING MICROTUBULE DYNAMICS AND CHROMOSOME MOVEMENT
… chromosome segregation. HURP is an important microtubule-associated protein for stabilizing and bundling the mitotic spindle. Depletion of HURP delays the mitotic progression, but the underlying mechanism remains unknown. Our research identifies a new interaction partner of HURP in regulating …
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Design and Synthesis of CDK-5 and MEK-5 Inhibitors and Synthesis towards Tubulysin Analogs
CDK-5 is associated with hyperphosphorylation of the microtubule-associated protein tau, formation of neurofibrillary tangles, and possibly an acceleration of the neurodegenerative progression of Alzheimer's disease. C6-O linked benzimidazoles and C-4 benzamide and phenylacetamide benzimidazoles …
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RNA-based therapeutic approaches for FTDP-17
… differential splicing caused due to mutations in Microtubule associated protein tau (MAPT) gene (Esther et al., 2002). This PhD thesis focuses on developing RNA-based therapeutic approaches to address FTDP-17. CHAPTER 1 introduces a broad range of topics such as splicing mechanism, …
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Studies of hyperphosphorylated tau aggregation and cytotoxicity
Diffusible aggregates of the microtubule-associated protein tau have been challenging to assemble and characterize, despite their important role in the development of tauopathies. We found that sequential hyperphosphorylation by protein kinase A in conjugation with either glycogen synthase kinase …
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Immunological investigations into synaptic plasticity
… chick brain using antisera to the cytoskeletal proteins (Xtubulin and microtubule-associated protein 2 following passive avoidance training and 3) using antibodies to synaptically-enriched antigens to map time- and locus-specific changes in hippocampal subfields following long-term potentiation …
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Identification of binding protein with kinesin18B
Microtubules play an important role in intracellular transport of vesicles and organelles in higher eukaryotic cells. This transport depends on the activity of motor proteins that interact with microtubules. Most kinesins move cargoes outwards toward the cytoplasmic membrane. Members of the kinesin …
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A molecular analysis of the relation between TDP-43 and tau pathology
Tau is a microtubule associated protein found in inclusions in tauopathies including Alzheimer's disease. One known cause of neurodegeneration is an excess of exon 10 inclusion in tau mRNA which is caused by several mutations in the MAPT gene, encoding tau. Processing of the Amyloid Precursor …
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Dual Roles for NBR1 in Bone Remodelling and Autophagosomal Protein Degradation
… of BRCAJJ is a ubiquitously expressed scaffold protein that mediates intracellular functions through protein-protein interactions. The C-terminal UBA domain of Nbrl binds mono- and polyubiquitinated chains whilst the N-terminal PB1 domain interacts with the structurally similar protein p62. The …
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Genetic Characterisation of Neurodegenerative disorders
… of these susceptibility genes, MAPT, that of the microtubule associated protein, tau, is an important genetic risk factor for neurodegenerative diseases. There are two major MAPT haplotypes at 17q21.31 designated as H1 and H2. In order to dissect the relationship between MAPT variants and the …
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Small Molecules Targeting and Modulating Toxic Tau Oligomeric Strains
… aggregation and accumulation of tau, a microtubule-associated protein. Tau aggregates are heterogeneous and can be divided into two major groups: large metastable neurofibrillary tangles (NFTs) and oligomers. Recently, it has been shown that tau oligomers are highly toxic in vitro and …
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Autophagy gridlock in tauopathy
… of intracellular aggregates containing the microtubule associated protein tau. Bulk degradation of aggregation-prone proteins can occur via autophagy. Here, we utilized the previously developed model of human tauopathy in Drosophila to examine how autophagy modulates human tau toxicity and …
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Using Microscopy to Examine Mechanisms of Cell Division
… during cell division requires the assembly of a microtubule-based mitotic spindle. In the research presented here, I examined two aspects of mitotic spindle morphogenesis. First, I looked at how chromosomes attach to microtubules in mitosis. The capture of microtubule plus-ends by kinetochores …
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Inhibition of Alzheimer’s type toxic aggregates of tau with fungal secondary metabolites
Tau is a microtubule-associated protein that is typically found in the axons of neurons. The aggregation of the tau is a significant event in many neurodegenerative diseases including Alzheimer's disease. In these disease tau dissociates from microtubules and begins to form toxic insoluble …
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Using Drosophila to study the contribution of human kinases to tau toxicity
The major neuropathological feature associated with tauopathies is the aggregation of the microtubule associated protein tau within neurons. Aberrant phosphorylation events on tau contribute to the aggregation during disease. The kinases and the phosphorylation sites on tau responsible for the …
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Disease-modifying effects of human small heat shock proteins in zebrafish models of neurodegeneration
… characterised by the build-up of misfolded proteins and degeneration of brain structures. Tauopathies are a collective of >20 such diseases featuring abnormally aggregating tau, a microtubule-associated protein normally acting to stabilise these protein cargo tracks. There is currently no …
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UNDERSTANDING THE PATHOLOGICAL EFFECTS OF EXOGENOUS MONOMERIC TAU PROTEIN AND THE DEVELOPMENT OF NOVEL TREATMENTS FOR ALZHEIMER’S DISEASE
Microtubule-associated protein tau (tau) is known to play a role in Alzheimer’s disease (AD) through pathways resulting in the gradual formation of neurofibrillary tangles. The uptake of monomeric tau from the extracellular medium, and its aggregation at low pH inside of neurons has previously been …
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The role of Ena/VASP and associated proteins in regulation of neuronal morphology and filopodia architecture
… remain poorly understood. The Ena/VASP family of proteins function as key signaling molecules that influences actin reorganization in response to environmental cues, and has been implicated in many aspects of development. My work has focused on defining the mechanisms by which the brain-specific …
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