Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"microtubule inhibitor"”.
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The role of tubulin in ganglioside-induced ramifications in cultured rat brain microglia
… in the absence or presence of cytoskeletal inhibitors and examined the resultant morphological changes. While LPS-induced ameboid shapes were blocked by all inhibitors, actin inhitibors and microtubule inhibitor, Ganglioside-induced ramifications were blocked by either paclitaxel or …
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Dysregulation of of phospholipid-specific phagocytosis by B1 B cells in diet-induced obese mice
… B1 cells and macrophages can be inhibited by the microtubule-inhibitor, Colchicine, in a dose-dependent manner. Most intriguingly, upon chronic high-fat diet (HFD) consumption by the host, B1 cell phagocytosis starts to lose antigen-specificity for PtC. Morphologically, some of these B1 B cells in …
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Mechanical Confinement and Heat as Drivers of Aneuploidy in Cancer
… losses These effects phenocopy nocodazole, a microtubule inhibitor, and transcriptional analysis identifies confinement-induced dysregulation of mitotic programs. These results introduce the concept of a mitotic memory, in which transient mechanical stress on mitotic cells leaves lasting …
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Chemoligand therapy for metastatic castration-resistant prostate cancer
… fused into a single drug the benefits of microtubule inhibition and theranostics, which are both standard of care in mCRPC. To achieve this, the design of the drug built on the general structure of chelator-containing glutamate-ureido-based radiopharmaceuticals for radioligand therapy. …
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Discovery of Novel Tubulin Inhibitors and Selective Survivin Inhibitors for Advanced Melanoma and Total Synthesis of Bioactive 20S-hydroxyvitamin D3
… develop new generations of bioavailable tubulin inhibitors targeting the colchicine binding site and selective small-molecule survivin inhibitors for treating advanced melanoma. Extensive structure-activity relationship (SAR) studies of lead molecules ABI-231 and UC-112 have been performed.</p> …