Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"microtubule inhibition"”.
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Anti-candida and Anti-virulence Activity of Essential Oils and Their Components
… to defects at the cell membrane. However, microtubule inhibition also plays a role in limiting hyphal growth. I explored the microtubule defects and how they relate to Kar3p, a member of the kinesin-14 family shown to be linked to microtubule stability. Interestingly, both tubulin and Kar3 …
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Synthesis Of Substituted Pyrrolo[2,3-D]Pyrimidines As Microtubule-Binding Agents and HSP90 Inhibitors
… background and recent advances in the areas of microtubule-binding agents and heat shock protein 90 (HSP90) inhibitors as anticancer agents are briefly reviewed. The work in this dissertation is centered on the synthesis of substituted pyrrolo[2, 3-d]pyrimidines as potential anticancer agents …
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Chemoligand therapy for metastatic castration-resistant prostate cancer
… fused into a single drug the benefits of microtubule inhibition and theranostics, which are both standard of care in mCRPC. To achieve this, the design of the drug built on the general structure of chelator-containing glutamate-ureido-based radiopharmaceuticals for radioligand therapy. …