Global ETD Search
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Showing 1 to 20 of 286 for “"microspheres"”.
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Sonochemically-produced proteinaceous microspheres
… into liposomes to coacervation into polymeric microspheres. Previously, Suslick and coworkers have used high-intensity ultrasound to generate nonaqueous-filled serum albumin microspheres. The mechanism involved the oxidation of cysteine residues by sonochemically generated superoxide to form …
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Glass microspheres for medical applications
"Radioactive dysprosium lithium borate glass microspheres have been developed as biodegradable radiation delivery vehicles for the radiation synovectomy treatment of rheumatoid arthritis. Once injected into a diseased joint, the microspheres deliver a potent dose of radiation to the diseased …
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Microspheres and Nanoparticles From Ultrasound
In the case of titania microspheres, they are rapidly taken up into the cytoplasm of mammalian cells and nearly noncytoxic. Small molecules like Rhodamine and DHED (dehydroevodiamine HCl; Alzheimer's disease therapeutic) can be delivered along with them. Furthermore, synthesis of carbon …
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Polymer microspheres for vaccine delivery
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1996.
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Oral uptake and distribution of microspheres
… initially with Fluoresbrite™ carboxylate latex microspheres (0.87 m diameter) which were administered orally to rats. Microsphere numbers within blood samples were then quantified using fluorescence microscopy or FACS technology. These studies were prone to quantitative error, but indicated that …
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The Biomedical Applications of Protein Microspheres
Microspheres were produced containing a core of aqueous or organic liquids (i.e., microcapsules) or air (i.e., microbubbles). The microspheres were stabilized by a 60--100 nm protein shell (approximately 10 molecules). The small microsphere diameter (<5 microns) permitted the intravenous injection …
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Disulfide Cross -Linking in Protein Microspheres
Microspheres composed of either thiol-modified myoglobin or albumin have been extensively examined by a combination of techniques including SDS-PAGE, SEC, and MALDI mass spectrometry peptide mapping. Electrophoresis and chromatography confirm the presence of higher molecular weight protein units as …
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Core -Shell Microspheres for Biomedical Applications
… imaging agents. Core-shell protein or polymer microspheres are biocompatible vesicles that have been used to meet the goal of transporting drugs or contrast agents to diseased tissues via the circulatory system. They consist of a hydrophobic core surrounded by a protein or polymer shell. …
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Stability of proteins within biodegradable microspheres
… particular, poly(lactic-co-glycolic acid) (PLGA) microspheres have been extensively studied for controlled-release protein delivery. However, significant issues arise in formulating such delivery systems since few proteins have been successfully encapsulated and released from these microspheres. …
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Improved swellable polymer microspheres for chemical sensing
<p>Derivatized lightly crosslinked polymer microspheres that swell and shrink as a function of pH have been investigated to develop polymeric transduction elements for fiber optic sensors and other sensors. The microspheres were immobilized in hydrogels forming a membrane. The membranes look turbid …
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Production and Surface Modification of Protein Microspheres
… covalently linked to the surface of the albumin microspheres. A flow cytometry assay with KB cells, which express high levels of folate receptor, was unable to detect specific targeting of the microspheres under flow cytometry conditions.
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Crush Strength Analysis of Hollow Glass Microspheres
Porous Wall Hollow Glass Microspheres (PWHGMs) were developed by the Savannah River National Laboratory. What makes these microspheres unique is the interconnected porosity spread throughout their wall allowing various materials to travel from the surface to the hollow interior. With their …
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Silica Microspheres Functionalized with Self-assembled Nanomaterials
… of nanomaterials deposited onto the silica microspheres. In particular, we fabricate multiple functional microspheres with different ISAM film thickness and Au NPs density. We find that the Q factors of these microspheres are mainly limited by optical absorption in the case of the ISAM film, …
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Magnetoacoustic chemical sensors based on swellable polymer microspheres
… sensors based on swellable polymer microspheres. The magnetoacoustic sensor was used to monitor viscosity of starch solution, water loading, and 2-hydroxyethyl methacrylate polymerization.</p><p>Poly(vinylbenzyl chloride) (polyVBC) microspheres were prepared by suspension …
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Enzyme microspheres for biosensing and cell signaling perturbation
Concentration of lactate in human blood or saliva is an important indicator for cardiac diseases. Conventional measurement of analytes in complex solution usually requires separation, which is time consuming. To bypass these problems, we developed enzyme based sensor arrays that rapidly and …
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Enzymatically active microspheres for self-propelled colloidal engines
<p>Micro- and nano-motors have attracted numerous attentions from various scientific areas due to their potential applications. Most studies on self-propelled colloidal engines have exploited catalytic decomposition of hydrogen peroxide to drive the motor. Since the hydrogen peroxide is caustic, it …
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The delivery of bioactive proteins using biodegradable microspheres
In this project, antigen-containing microspheres were produced using a range of biodegradable polymers by single and double emulsion solvent evaporation and spray drying techniques. The proteins used in this study were mainly BSA, tetanus toxoid, F1 and V, Y. pestis subunit vaccines and the …
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CNS delivery of antisense oligodeoxynucleotides using biodegradable microspheres
… for a sufficient duration. Biodegradable microspheres have previously been developed for the potential systemic delivery of antisense oligodeoxynucleotides and offer an excellent strategy for central administration of antisense oligodeoxynucleotides, providing a sustained-release delivery …
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Methods to Tailor Protein Microspheres for Biomedical Applications
… the core, shell, and surface of the protein microspheres. In addition, I have shown that the size of these spheres can be reduced from the micron scale to the nano scale. These modifications have thus improved the versatility and the applicability of the microspheres to a variety of …
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Elucidation of Drug Release Mechanisms in PLGA Microspheres
… elucidate mechanisms of drug release in PLGA microspheres. We showed the effect of microsphere size and presence of an antacid on the stability and release of plasmid DNA from PLGA microspheres. We demonstrated that the use of Mg(OH)2 as a stabilizing excipient affected the surface porosity of …
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