Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"microsatellite instability"”.
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The Microsatellite Instability High Endometrial Tumor Microenvironment and Identifying Predictive Biomarkers of Response to Pembrolizumab
<p>Objective: Half of patients with microsatellite instability high (MSI-H) endometrial cancer are treatment-refractory to pembrolizumab. We sought to evaluate the MSI-H endometrial tumor samples to examine differences in the tumor microenvironment (TME) and identify transcriptomic signatures …
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Know Thy Cell-Free DNA: Early Detection of Microsatellite Instability Using Ultra-Low-Pass Cell-Free DNA Sequences
Microsatellites are short segments of repeated DNA motifs (i.e., base pair patterns) that are widespread in our genomes. Microsatellites are inherently more mutable than other genomic locations, and since cancer cells undergo many more cell divisions, microsatellites are useful for distinguishing …
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Clinical importance of microsatellite instability and promoter methylation of DNA in colorectal cancer // Клинично значение на микросателитната нестабилност и промоторното метилиране на ДНК при колоректален карцином
Проучват се проспективно 189 пациента с колоректален карцином (КРК), от които 98 българи и 81 германци. Събрани са данни относно фамилната обремененост с карцином, локализацията на КРК по хода на дебелото черво, хистологията и стадия по TNM класификацията. При 82 пациенти е проследена 5 г. …
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TREMELIMUMAB AND DURVALUMAB COMBINATION FOR THE NON-OPERATIVE MANAGEMENT OF MICROSATELLITE INSTABILITY HIGH RESECTABLE GASTRIC OR GASTROESOPHAGEAL JUNCTION CANCER: RESULTS OF COHORT 1 OF THE MULTICENTRE, SINGLE-ARM, MULTI-COHORT, PHASE II INFINITY STUDY
Introduzione: Nel carcinoma gastrico o della giunzione gastroesofagea (GC/GEJC), resecabile è ormai dimostrato il potente valore prognostico positivo e il potenziale valore predittivo per la mancanza di beneficio dalla combinazione di chemioterapia adiuvante/perioperatoria della presenza di alta …
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Global Microsatellite Content Potentially Distinguishes Humans, Primates, Animals, and Plants
Microsatellites are highly mutable, repetitive sequences commonly used as genetic markers, but they have never been assayed en masse. Using a custom microarray to measure hybridization intensities of every possible repetitive nucleotide motif from 1-mers to 6-mers, we examined 25 genomes. Here we …
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DISSECTING RESISTANCE TO IMMUNOTHERAPY IN MSS COLORECTAL CANCER
… exhibiting DNA mismatch repair deficiency and microsatellite instability (MSI) often display favorable responses to immune checkpoint inhibitor (ICI) therapies, in contrast to mismatch repair proficient and microsatellite stable (MSS) tumors. While the high mutational burden and elevated …
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Mutational analysis of the DNA mismatch repair genes, hMLH1 and hMSH2, in South African colorectal cancer patients
… of DNA mismatch repair genes, the presence of microsatellite instability (MSI) was investigated. In total 40 patients presented with MSI-H tumours, 27/109 (24,8%) tumours from black patients and 13/110 (11,8%) tumours from Caucasian patients. The proportion of MSI-H tumours from black patients …
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Mechanism of acquired temozolomide resistance in glioblastoma
… classical markers of MMR deficiency, namely microsatellite instability and a mutator phenotype. Our results suggest that the involvement of MMR deregulation in mediating TMZ resistance is likely to be much more prevalent than previously appreciated. Additionally, we have employed …
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From Education to Tumour Characteristics in Colorectal Cancer: An Analysis of the Pathways.
… to tumour characteristics (stage, grade, microsatellite instability (MSI), and site) that are associated with CRC prognosis. Data came from the Ontario Familial Colon Cancer Registry. Pathways were evaluated for effect modification by sex and two indicators of CRC genetic susceptibility …
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The Immune Microenvironment of Microsatellite Instable Endometrial Cancer
… tumor types have shown that tumors with high microsatellite instability (MSI-H) have increased immunogenicity and response to immunotherapy treatments compared to microsatellite stable (MSS) tumors. Patients with MSI-H EC may also benefit from these therapies; however, the tumor immune …
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Novel genomic technologies and molecular diagnostics in Colorectal Cancer
… into groups according to the presence of microsatellite instability (MSI) and chromosomal instability (CIN). Of the 51 CRCs, 13.73% were MSI and 86.27% were microsatellite stable (MSS). The frequency of KRAS mutations in MSI-H and in MSS cancer was 28.57% and 40.91%, respectively. To …
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KRAS Codon 12 and Codon 13 Mutations in Relation to Overall Survival among Colorectal Cancer Patients: A Systematic Review and Meta-Analysis
… not study-specific estimates were adjusted for microsatellite instability (MSI) status explained part of this heterogeneity (p < 0.01) and revealed that associations were more modest in the presence of adjustment for MSI status (pooled HR = 1.21, 95% CI: 1.07–1.36, 9 studies, p-het = 0.09) and …
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Clinical Significance of Homologous Recombination Deficiency Score Testing In Endometrial Cancer
… patient samples were tested for HRD score, microsatellite instability (MSI) and high mutation load (HML) using a next generation sequencing assay targeting the coding regions of 43 genes and 54,091 genome wide single nucleotide polymorphisms (SNPs) developed by Myriad Genetics. The HRD score …
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Harnessing CRISPR-Cas9 screens to identify functional genetic interactions
… CRISPR-Cas9 screens in cancer models of microsatellite instability (MSI) and made headway into identifying novel genetic interactions that can drive resistance or hypersensitivity to WRN-depletion. This work amplifies the evidence for WRN-depletion as a promising new avenue for …
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Evaluation of novel prognostic factors In ovarian carcinoma
… of prognostic significance. For eighteen cases, microsatellite instability (MSI) was evaluated by using fluorescently labeled primers at nine loci. LOH was a common event in ovarian carcinoma but MSI was infrequent. Molecular and clinical marker multivariate analysis indicated: (a) residual …
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The role of deficient mismatch repair system in Lynch syndrome and the increased risk of colorectal cancer
… MMR system often results in the phenotype microsatellite instability (MSI) which is a strong diagnostic indicator of Lynch syndrome. The connection between Lynch syndrome and defects in mismatch repair genes have had important implications in the diagnosis and treatment of Lynch syndrome …
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Common genetic variance at the SMAD9 colorectal cancer risk locus influences tumour mutational phenotype
… revealed a relative depletion of highly mutated microsatellite instable (MSI) tumours on the risk allele background. This was verified in a meta-analysis of 5 independent cohorts (OR=0.73, 95%CI 0.63-0.86, p=1x10-4). Separate case-control studies for MSI and microsatellite stable (MSS) CRC risk …
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A cohort study of sex differences and prognostic biomarkers in colorectal cancer
… independently, in male, but not in female, CRC. Microsatellite instability (MSI) correlated to distinctive clinicopathological features, cyclin D1 expression, and independently predicted a good prognosis in stage III-IV CRC. Moreover, beta-catenin overexpression correlated independently with a …
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Characterizing Chromosomal Aberrations in Cells Deficient for Both ATM and MSH2
… two to five months of age and have increased microsatellite instability, which predisposes <em>MSH2<sup>-/-</sup></em> mice to carcinomas. However, mice deficient in both ATM and MSH2 are unable to survive beyond postnatal day 21 (P21). The observed lethality in …
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