Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 382 for “"microsatellite"”.
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Imputation of Microsatellite Markers With Tag SNPs
<p>Of the two most common forms of genetic variation in the human genome, Single Nucleotide Polymorphisms (SNPs) and Variable Number Tandem Repeat Polymorphisms (VNTRs), SNPs are much more easily and inexpensively assayed in a high-throughput manner. For this reason, we seek to explore methods that …
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Feasibility of Microsatellite Active Debris Removal Systems
… problem an investigation of the feasibility of a microsatellite active debris removal system was conducted. Through proposing a novel concept of operation, utilizing a grapple-and-tug system architecture, and by analyzing each resultant mission phase in the frame of a representative example, it …
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The Immune Microenvironment of Microsatellite Instable Endometrial Cancer
… tumor types have shown that tumors with high microsatellite instability (MSI-H) have increased immunogenicity and response to immunotherapy treatments compared to microsatellite stable (MSS) tumors. Patients with MSI-H EC may also benefit from these therapies; however, the tumor immune …
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Quantifying Intestinal Stem Cell Dynamics Using Microsatellite Sequencing
… leading to the contraction or expansion of a microsatellite during mitotic replication, can be employed to enable the detection of a single clone. Previous studies have shown that quantification of clone size over time allows inference of the functional stem cell number and stem cell …
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Novel Microsatellite Detection, Microsatellite Based Biomarker Discovery In Lung Cancer And The Exome-Wide Effects Of A Dysfunctional DNA Repair Mechanism
… In particular, repetitive sequences, called microsatellites (MST), which are tandem repeats of 1 to 6 bases, are known to be mutational hotspots and have been linked to diseases, such as Huntington disease and Fragile X syndrome. This work represents a significant effort towards closing this …
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Selection for Run1-Ren1 Dihybrid Grapevines Using Microsatellite Markers
… in a grapevine hybrid family using flanking microsatellite markers. Segregation of the powdery mildew resistance phenotype was evaluated under in vitro and greenhouse conditions independently of the genotype data. Combined analysis of phenotypic and genotypic segregations confirmed that Ren1 …
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Determining Feasibility of a Propulsionless Microsatellite Formation Flight Mission
<p>Benefits of developing missions with multiple formation flying spacecraft as an alternative to a traditional monolithic vehicle are becoming apparent. In some cases, these missions can lower cost and increase flexibility among other situational advantages. However, there are various limitations …
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Design and control of microsatellite clusters for tracking missions
… that could be accomplished using a cluster of microsatellites. This thesis addresses the design of microsatellite clusters to accurately track a target in a probabilistic suborbital occupancy corridor by pursuing the following: orbit determination using optimal measurement principles, cluster …
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Global Microsatellite Content Potentially Distinguishes Humans, Primates, Animals, and Plants
Microsatellites are highly mutable, repetitive sequences commonly used as genetic markers, but they have never been assayed en masse. Using a custom microarray to measure hybridization intensities of every possible repetitive nucleotide motif from 1-mers to 6-mers, we examined 25 genomes. Here we …
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Evaluation of microsatellite markers for parentage verification in South Africa Angora goats
… and lead to increased selection accuracy. Microsatellite markers were evaluated for inclusion into a parentage verification panel, to be applied in the South African Angora goat population. The panel of 18 microsatellite markers was constructed, optimized and tested in 200 South African …
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The human molecular clock and mutation process : a characterization using microsatellite DNA
… on studying human evolution through the use of microsatellites, which are simple repetitive sections of DNA of typically 1-6bp motifs (e.g. CACACACACA) that are highly polymorphic and highly mutable. The first aim is to establish that microsatellites are useful as reliable molecular clocks, such …
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Microsatellite-based genetic profiling for the management of wild and captive flamingo populations.
… lack of genetic data for flamingo populations. Microsatellites are loci composed of 2-6 base pair tandem repeats, scattered throughout higher eukaryotic genomes, often exhibiting high levels of polymorphism and heterozygosity. These loci are thus important genetic markers for identity, parentage …
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Comparative Analysis of Microsatellite and Mitochondrial Genetic Variation in <em>Ixodes Scapularis</em>
… nuclear, bi-parentally inherited markers such as microsatellite loci can provide additional information at a finer scale. Furthermore, previous studies were based on either limited sampling, which did not represent the whole geographic range of the tick, or were based on single molecular markers. …
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MICROSATELLITE ANALYSIS OF POPULATION STRUCTURE IN THE SANTA ANA SPECKLED DACE (RHINICTHYS OSCULUS)
… was to characterize and identify polymorphic microsatellite markers for <em>R. osculus</em> in which twenty-three were identified through Illumina pair-end sequencing. Seven of these loci were then used to examine the patterns of genetic variation and population structure that occurred within …
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Development and Characterization of Microsatellite Markers for the Grain Amaranths (Amaranthus spp. L.)
… a set of highly informative, reproducible microsatellite markers for the grain amaranths. A total of 1457 clones were sequenced from three genomic libraries enriched for the microsatellite motifs AAC, AAT and AC. Of these, 353 (24%) contained unique microsatellites. An additional 29 …
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Estimating Population Numbers of Black Bears (Ursus Americanus) in Eastern Kentucky Using Microsatellite Analysis
… 108 hair and scat samples were obtained. Eight microsatellite markers and one SRY marker were used to genotype and determine the sex of individual black bears. A minimum of thirty- nine different individuals (26 males and 13 females) were identified during the study period. Most of the …
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CHARACTERIZATION OF MICROSATELLITE LOCI AND PILOT POPULATION GENETIC ANALYSIS IN HICKORY SHAD, ALOSA MEDIOCRIS
… analysis of this species, employed 12 neutral microsatellite loci to estimate genetic diversity and population structure in tributaries of lower Chesapeake Bay, Virginia including James River and its tributaries (Appomattox and Chickahominy Rivers), Rappahannock River, and Pamunkey River. …
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Phylogeography of eastern leatherwood (Dirca palustris L.) resolved by chloroplast sequencing and microsatellite genotyping
… niche modeling, chloroplast sequencing, microsatellite genotyping, and phenotypic investigations to answer questions about the historical and contemporary distribution of populations and genes of D. palustris across the landscape of eastern North America. Ecological niche modeling …
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