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Showing 1 to 20 of 29 for “"microglobulin"”.
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Beta2-microglobulin and antichromatin antibodies can be a disease activity markers in Systemic Lupus Erythematosus in Koreans
BACKGROUNDS: Beta2-microglobulin and antichromatin antibodies have been described in patients with systemic lupus erythematosus (SLE) and it has been suggested that their presence is associated with lupus disease activity. We have investigated the clinical significance of beta2-microglobulin and …
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THE LYSOSOMAL AMYLOID AGGREGATION OF B2-MICROGLOBULIN PROMOTES MULTIPLE MYELOMA PROGRESSION: A MOLECULAR FOCUS ON THIS PRO-CANCER MECHANISM
… functionalities. A widely studied example is β2-microglobulin (β2m), whose aggregation into amyloid fibrils underlies dialysis-related amyloidosis. Beyond this role, β2m also serves as prognostic factor for several hematological malignancies, including multiple myeloma (MM). Recent studies …
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A fluidized immunoadsorption device for removing beta-2-microglobulin from whole blood : a potential treatment for dialysis-related amyloidosis
… has been associated with the accumulation of 2-microglobulin (2m). Excluding transplantation, existing kidney replacement technologies are believed to remove insufficient quantities of P2m for the prevention of DRA, as they are non-specific and based on size-exclusion. A proposed DRA therapy is …
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The Characterization of Hemodialysis Membranes in Miniaturized Dialyzers
… ultrafiltration coefficient, clearance of Beta-2 Microglobulin (B2M), and SC of B2M.These outcomes suggest that the miniaturized dialyzers can effectively differentiate performance characteristics representing hemodialysis membrane and fiber design. This indicates that the miniaturized dialyzers …
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Role of nuclear factor kappa B (NFkB) in the vascular complications of diabetes.
… the role of NFĸB activation, HIF1-α and β2-microglobulin in U937 cells mRNA via culturing U937 under high glucose (HG) condition in different concentrations (5.5mM, 20mM and 40mM). The NFĸB and β2-microglobulin PCR product was not detected during incubations with various glucose …
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Effects of Long-term Strenuous Exercise on Oxidative DNA Damage and Proteinuria in Humans
… including urinary total protein, albumin, beta2-microglobulin, N-acetyl-beta-D-glucosaminidase, and creatinine. The overall results showed that there were significant whole-body DNA oxidation and post-exercise proteinuria after the half- and full-Ironman triathlon races, but these levels …
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Effects of Long-term Strenuous Exercise on Oxidative DNA Damage and Proteinuria in Humans
… including urinary total protein, albumin, beta2-microglobulin, N-acetyl-beta-D-glucosaminidase, and creatinine. The overall results showed that there were significant whole-body DNA oxidation and post-exercise proteinuria after the half- and full-Ironman triathlon races, but these levels …
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Massenspektrometrische Untersuchung posttranslationaler Modifikationen
… Klonierung eines der ausgewählten Proteine (ß2-Microglobulin) in E.coli mittels molekularbiologischer Techniken. Ziel der Klonierung war es festzustellen, zu welchem Zeitpunkt die zuvor entdeckten posttranslationale Modifikation im Rahmen der natürlichen Alterung von Proteinen auftritt.
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β2-mikroglobulino gryninimas ir skysčio-skysčio fazių atsiskyrimo tyrimai /
β2-microglobulin is an important component of the major histocompatibility complex class I (MHC-I) molecule, which is found on almost all nucleated cells. Its main role in the immune system is the presentation of peptide antigens to T cells. In addition to its physiological functions, β2M is …
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Characterization of the degradation of wild-type and mutant HFE proteins during stress signalling in the endoplasmic reticulum
… the interaction with its co-chaperone β2-microglobulin. The resulting misfolded protein is retained within the endoplasmic reticulum (ER) where it activates the Unfolded Protein Response (UPR) and is subjected to proteasomal degradation. The absence of functional HFE at the cell surface …
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Engineering Proteins Encoded by the Major Histocompatability Complex
… 2alpha3) and a light chain called beta2-microglobulin (12 kDa) that associates with the alpha3 domain. Peptides bind within a cleft formed by two helices of the alpha1 and alpha 2 domains. Peptide-MHC class I complexes are recognized by a receptor (T cell receptor, TCR) on cytotoxic T …
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Integrative genomic approaches to dissecting host-tumor and host-pathogen immune processes
… with cytolytic activity, including beta-2- microglobulin (B2M), HLA-A, -B and -C and Caspase 8 (CASP8), highlighting loss of antigen presentation and blockade of extrinsic apoptosis as key strategies of resistance to cytolytic activity. Genetic amplifications were also associated with high …
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Low molecular mass proteins as markers for renal function and dialysis efficiency
… result from our study showed that cystatin C, β2-microglobulin and β-trace protein can be used as markers for the efficiency of haemofiltration (HF) and haemodiafiltration (HDF). The elimination pattern of β-trace protein differs between HDF and HF and the free proteins might therefore be useful …
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Molecular and morphological studies on non-healing venous leg ulcers.
… Furthermore, a novel heme-scavenger, ?1-microglobulin, was identified in these ulcers. Taken together, the data suggests a possible link between bacterial presence, neutrophil activation and HBP-release in venous ulcers, which will help to explain the clinical observation of classic …
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Amyloid fibril structure of peptides and proteins by magic angle spinning NMR spectroscopy and dynamic nuclear polarization
… protein transthyretin (TTR); and P2- microglobulin (32m), a 99-residue protein associated with dialysis-related amyloidosis. The TTR(105-115) case exemplifies our efforts to characterize the hierarchy of structures present in the fibril form, including the organization of the Pstrands …
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Investigating biomarkers in clinical samples that are predictive of response in multiple myeloma
… (ZAG), Serum Amyloid A protein (SAA), Beta-2-microglobulin (B2M), had higher abundance level with fold changes of 1.31 (p=0.00044), 1.32 (p=0.0077), 1.48 (p= 0.0000022), 3.01 (p=0.006) and 1.96 (p=0.0015) fold increase in non-responders compared to responders, respectively. In contrast …
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An investigation into the effects of inorganic element status on the accumulation and deposition of amyloid in various diseases.
… in senile plaques of Alzheimer's disease and β2 microglobulin (β2M) deposition in dialysis related amyloidosis. The major factor for amyloidosis appears to be an increase in the production of amyloidogenic proteins, resulting in the amyloid β sheet deposits. It is clear that conformational …
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Studies of Structure, Dynamics, and Interactions of Amyloid Fibrils by Magic Angle Spinning Solid State NMR
… formed by an amyloid related protein, ß2-microglobulin. In both solution and solid state NMR studies, we identified significant and specific chemical shift perturbations, agreeing well with previous crystallography studies.
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Subcellular Fractionation Methods for the Quantification of Endogenous Protein in Human Liver Using Targeted Proteomics
… human liver neonatal Fc receptor and beta 2-microglobulin were enriched in a post-nuclear supernatant, and a UPLC-MRM method was developed and validated to quantify these two proteins. Our quantitative results and determination of interindividual variability will aid the future development of …
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Characterisation of TAPBPR in immune cells
… is likely interacting with HLA-F bound to β2-microglobulin (β2m). To unravel the biology behind this interaction, phenotyping was performed. HLA-F is thought to be recognised by leukocyte immunoglobulin-like receptors (LILRs) or killer-cell immunoglobulin-like receptors (KIRs), and only …
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