Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 56 for “"microglial cells"”.
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Conjugated linoleic acid isomers anti-neuroinflammatory effects on activated microglial cells
… cell line, which are the resident immune cells in the CNS that play a key role in sustaining neuronal activity and immune balance. BV-2 cells were exposed to 25 μM of c9,t11-CLA, t10,c12-CLA, or oleic acid (OA) for 24 hours, after which they were stimulated with lipopolysaccharide (LPS). …
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Cell death and Pro-inflammatory Cytokine Release of Rat Microglial Cells by Naegleria fowleri
… cytopathic activity and cytotoxicity against rat microglial cells by the morphological observation and 51Cr release assay. In the present study, to determine whether a pathogenic N. fowleri lysate shows the cytopathic effects against primary cultured rat microglial cells, the morphological changes …
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LIPID COMPOSITION OF MICROGLIAL CELLS AND EFFECTS OF A REMYELINATION-PROMOTING ANTIBODY ON THE SPHINGOLIPID PATTERNS
… death are caused by the autoimmune attack of T cells that cross the blood-brain barrier resulting in the formation of sclerotic plaques (Pearce, 2005, Lubetzki and Stankoff, 2014). In the early stages of the disease, damaged myelin is to some extent repaired, however the process is inefficient …
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Extracullular Atp Regulates Il-1beta Release From Microglial Cells Via Purinergic Receptor After In Vitro Trauma
Traumatic brain injury (TBI) induces a state of microglialactivation, which includes upregulation of macrophage functions and release inflammatory mediators such as certain inflammatory cytokines. Current literature suggests that interleukin-1Beta is an important cytokine mediator, which is …
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Cytopathic Effects of a Pathogenic Naegleria fowleri and an Anti-Nfa1 Antibody on Rat Microglial Cells
… tissue invasion, the adherence of amoeba to host cells is most important. The nfa1 gene (360 bp) was previously cloned from a cDNA library of pathogenic N. fowleri by immunoscreening, and produced a 13.1 kDa recombinant protein (rNfa1) that showed the pseudopodia specific localization by …
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The pathogenesis of murine retroviral-induced noninflammatory spongiform polioencephalomyelopathy: Neuronal degeneration is indirectly mediated by resident microglial cells
… lymphocytes, (3) CNS capillary endothelial cells, and (4) CNS pericytes and microglia. Splenic megakaryocytes, platelets, and cell free viremia contributed to systemic dissemination of virus to the CNS. Resident microglia served as the major reservoir and amplifier of virus infection in the …
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CANNABINOIDS DELTA-9-TETRAHYDROCANNABINOL (THC) AND CP55,940 ABLATE SPECIFIC CHEMOKINE AND CYTOKINE INFLAMMATORY RESPONSE IN BV-2 MOUSE MICROGLIAL CELLS ACTIVATED WITH HIV-1 PRO-INFLAMMATORY PROTEIN TAT
… inflammatory response on BV-2 mouse microglia cells caused by Tat. Within the constraints of the experiment, no major effects of cannabinoid treatment were observed at the level of the proteome as tested by two-dimensional gel electrophoresis . In contrast, these cannabinoids ablated the …
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The mechanism for paraquat toxicity involves oxidative stress and inflammation : a model for Parkinson's disease
… for paraquat-induced cytotoxicity to BV-2 microglial cells. Paraquat-induced ROS production was attenuate by inhibitors for NADPH oxidase, protein kinase C and extracellular signal-regulated kinases 1/2. Under inflammatory conditions, microglial cells respond to cytokines by induction of …
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CX3CR1 Neuroimmune Microglial Cell Forkhead Box Class O1 (FoxO1) Contributions to Metabolic Homeostasis
In the central nervous system (CNS), microglial cells are neuroimmune cells that act as the brain’s sentinel macrophages to protect and maintain a homeostatic functional state for a healthy brain. In this thesis, I will discuss how neuroimmune microglial cells contribute to systemic metabolic …
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Periventricular white matter damage in the post-natal brain in hypoxic conditions
… white matter (PWM) damage in neonates. Microglial cells and astrocytes play a crucial role in inflammatory response. This study investigated their role in PWM damage (PWMD) in hypoxic conditions. The potential mechanisms by which amoeboid microglial cells (AMC) and astrocytes induce …
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Obesity and neuroinflammation : the impact of adipocyte-derived extracellular vesicles on microglial cell signalling
… To understand the effects of AT-EVs on microglial cells and if this may be a contributing factor in the link between obesity and neuroinflammation. We hypothesise that AT-EVs will enhance the expression of pro-inflammatory signalling (pNF-κB expression) within microglial cells.Methods: …
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STRESS GRANULES MODULATE SYK TO CAUSE MICROGLIAL DYSFUNCTION IN ALZHEIMER’S DISEASE
Microglial cells in the brains of Alzheimer’s patients are recruited to amyloid beta (Aβ) plaques and exhibit an activated phenotype, but are defective for plaque removal by phagocytosis. To explore the molecular basis for these phenomena, I hypothesized that defects in the functions of the …
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Characterization of cathepsin B cysteine protease from Naegleria fowleri excretory-secretory proteins exerting immunomodulatory effects
… and both mechanisms lead to death of host cells. Several proteins secreted from N. fowleri are likely to be associated with contactindependent pathogenic mechanism of the amoeba. The excretory and secretory proteins of N. fowleri (Nf-ESPs) include phospholipase, proteases, peroxiredoxins …
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The bioactive role of omega-3 endocannabinoid epoxide regioisomers
… activation as well as neuroinflammation in BV-2 microglial cells. Our studies indicate that these eCB epoxides activate cannabinoid receptors with distinct receptor selectivity. They also show anti-inflammatory action by reducing nitrite production in lipopolysaccharide (LPS) stimulated BV-2 …
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Studies on the Damage Associated Molecular Patterns (DAMPs)-induced Inflammatory Events in the Brain Immune Cells
… molecules released by activated or necrotic cells and extracellular matrix (ECM) molecules that are upregulated upon injury or degraded following tissue damage. Recently, the list of DAMPs candidate molecules is getting longer and DAMPs has been proposed to have multifaceted functions in …
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Role of ICAM-1, a cell adhesion molecule, in morphological changes of BV2 microglial cell
Microglial cells, the major immune effector cells in the central nervous system, are activated in various brain injuries. Lipopolysaccharide (LPS), found in the outer membrane of Gram-negative bacteria, one of the major activator of microglia induces morphological changes and activation of the …
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The role of cytosolic phospholipase A2 in microglial signaling pathways during neuroinflammation
… injury. Microglia are the primary innate immune cells in the central nervous system (CNS). These cells are the first line of defense against foreign pathogens, and the exhibit multiple physiological roles including removing cellular debris and maintaining tissue homeostasis. Pathologic activation …
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TREM-2 Expression and Regulation in Inflammation and Ischaemia
Triggering receptor expressed on myeloid cells – 2 (TREM-2) is a receptor expressed mainly in myeloid cells. TREM-2 is involved in the resolution of inflammation through dampening Toll-like receptor (TLR) induced pro-inflammatory cytokine secretion and phagocytic functions. It is increased in …
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The Regulation of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 2 (SHP-2) in Brain Microglia
… the gangliosdies-, LPS-, and IFN-γ induced microglial activation. In both rat primary microglia and murine BV2 microglial cells, curcumin effectively suppressed the gangliosides-, LPS-, or IFN-γ-stimulated induction of COX-2 and iNOS, important enzymes that mediate inflammatory processes. …
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Gangliosides와 oxidized low density lipoprotein (oxLDL) 에 의한 신경교세포의 활성조절 및 그 기전에 대한 연구
… Inflammatory Responses in Brain Microglial Cells 19 1. Gangliosides Induce Nuclear Factor Binding to GAS/ISRE Elements 19 2. Gangliosides Induce the Phosphorylation of STAT1 and STAT3 23 3. Gangliosides Induce Phosphorylation and Activation of JAK1 and JAK2 25 4. Gangliosides …
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