Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 32 for “"microglial cell"”.
-
CX3CR1 Neuroimmune Microglial Cell Forkhead Box Class O1 (FoxO1) Contributions to Metabolic Homeostasis
In the central nervous system (CNS), microglial cells are neuroimmune cells that act as the brain’s sentinel macrophages to protect and maintain a homeostatic functional state for a healthy brain. In this thesis, I will discuss how neuroimmune microglial cells contribute to systemic metabolic …
-
Obesity and neuroinflammation : the impact of adipocyte-derived extracellular vesicles on microglial cell signalling
… neuroinflammation is poorly understood. Extracellular vesicles (EVs) are nanoparticles released from most cell types and aid in cell-cell communication. Adipocyte-derived extracellular vesicles (AT-EVs) are known to be involved in interorgan crosstalk during obesity and therefore may be a key …
-
Role of ICAM-1, a cell adhesion molecule, in morphological changes of BV2 microglial cell
Microglial cells, the major immune effector cells in the central nervous system, are activated in various brain injuries. Lipopolysaccharide (LPS), found in the outer membrane of Gram-negative bacteria, one of the major activator of microglia induces morphological changes and activation of the …
-
Comparison of Biochemical mechanisms of cigarette smoke and heated tobacco aerosol toxicity on microglial cell function under physiological and pathological conditions [Confronto dei meccanismi biochimici della tossicità del fumo di sigaretta e dell'aerosol di tabacco riscaldato sulla funzione delle cellule microgliali in condizioni fisiologiche e patologiche]
… del tabacco riscaldati (HTP) sulla funzione microgliale, concentrandosi sui profili tossicologici, sulle risposte infiammatorie e sullo stress ossidativo utilizzando condizioni di esposizione standard ISO e clinicamente rilevanti. La vitalità cellulare, la produzione di specie reattive …
-
The involvement of microglial activation in schizophrenia
Abnormal activation of brain microglial cells is widely implicated in the pathogenesis of schizophrenia. The disrupted balance of microglia phenotypes has been hypothesized to influence the clinical course of the disease and affect symptom severity. Previously, the pathophysiology of microglial …
-
Steroid induced neuroprotection of damaged photoreceptor cells
… Norgestrel was shown to protect against retinal cell death in two distinct mouse models of retinal degeneration: in the Balb/c light damage model and the Pde6brd10 (rd10) model. Little was known of the molecular workings of this compound however and thus this study aimed to elucidate the …
-
STRESS GRANULES MODULATE SYK TO CAUSE MICROGLIAL DYSFUNCTION IN ALZHEIMER’S DISEASE
Microglial cells in the brains of Alzheimer’s patients are recruited to amyloid beta (Aβ) plaques and exhibit an activated phenotype, but are defective for plaque removal by phagocytosis. To explore the molecular basis for these phenomena, I hypothesized that defects in the functions of the …
-
Dearomative hydroboration-enabled synthesis of idarubicinone and synthesis of minor cannabinoids and their metabolites
… the production of cytokines in a BV-2 mouse microglial cell line under inflammatory response.
-
The in vitro effects of chemokines on microglia: Implications for multiple sclerosis.
… central nervous system (CNS), are the primary cell to respond to injury in the brain, both in inflammation e.g. in multiple sclerosis (MS), and in trauma. Microglia can be activated in vitro by proinflammatory cytokines such as IFNgamma and TNFalpha and respond by secretion of cytokines, …
-
Effects of dietary intervention on inflammation and intrauterine growth restriction in neonatal piglets
… were sacrificed at PD14 and complete blood cell counts with differential, fatty acid profile, and fatty acid metabolite profiles of brain tissue were generated, and microglial cells were isolated and stimulated with 10 ng/mL LPS. In study 2, piglets were given a 10 µg/kg i.p. injection of …
-
Uncovering Functional Alzheimer’s Disease Variants and Their Effector Genes through Single-Cell CRISPRi Screening and 3D Genomics
… promoter-focused Capture C from brain-relevant cell models. We identified 89 candidate causal SNPs and 69 effector genes. Second, we designed a single-cell CRISPRi screen to perturb 74 candidate regulatory regions and assessed their transcriptional response in the human microglial cell line, …
-
Apolipoprotein E alters the association of neuroinflammation with Alzheimer's disease
… within a community based aging cohort (n = 186). Cellular density of Iba1, a marker of microglia, was positively associated with tau pathology as measured by AT8 immunostaining (B = 0.459, p = 0.028) in e4 positive participants but not in e4 negative participants. Analysis of cytokines implicated …
-
The Role of Neuroinflammation in Alzheimer's Disease
… bind to pattern recognising receptors on glial cells in the brain, causing the production and release of pro-inflammatory messengers, which contribute to disease progression. By studying the relationship between protein aggregation and neuroinflammation at early stages, we can begin to uncover …
-
Aging Exacerbates the Brain Response to a Peripheral Immune Stimulus
… of aged mice, which suggests constitutive microglial cell activation. This was accompanied by an increase in magnitude and duration of IL-1beta, IL-6, and TNFalpha mRNA following LPS. Because excessive pro-inflammatory cytokines can cause dendritic retraction which may enhance …
-
Mechanisms of cytosolic DNA sensing and neuroinflammation in ataxia-telangiectasia
… in ATM kinase, a master regulator of the cellular response to DNA damage, including DNA double stand breaks and oxidative stress. A-T is a multisystemic disease that manifests in the CNS as cerebellar degeneration, leading to debilitating ataxia. ATM deficiency and the consequential …
-
The bioactive role of omega-3 endocannabinoid epoxide regioisomers
… activation as well as neuroinflammation in BV-2 microglial cells. Our studies indicate that these eCB epoxides activate cannabinoid receptors with distinct receptor selectivity. They also show anti-inflammatory action by reducing nitrite production in lipopolysaccharide (LPS) stimulated BV-2 …
-
Investigating the effects of TREM2, APOE and PILRα variants on microglial functions and neuronal loss
Microglia are the primary immune cells of the central nervous system (CNS). They utilise a host of signals, receptors, and processes to maintain homeostasis and to resolve exogenous and endogenous insults in the brain. Mounting evidence over recent years has highlighted the central role of …
-
THE ANTI-INFLAMMATORY AND PRO-NEUROGENIC ROLE OF PPARα IN MODULATING RADIATION-INDUCED BRAIN INJURY
… hippocampal neurogenesis and inhibiting microglial activation following WBI represent key strategies to minimize WBI-induced morbidity. Peroxisomal proliferator-activated receptors (PPARs) are ligand-activated transcription factors that possess anti-inflammatory properties. We hypothesize …
-
The Effect of Resveratrol on Lipopolysaccharide-induced Dopaminergic Deficits and BV-2 Cell Activation
… (Ling et al., 2002). Activation of the extracellular regulated kinases, ERK1/2 and ERK5, the downstream targets in the mitogen-activated protein kinase (MAPK) pathway, has been shown to be involved in the dysregulation of the inflammatory process (Cuschieri and Maier, 2005). Consequently, …
-
CD33 and TREM2 regulation of microglial functions
… CNS development, homeostasis and pathology, and microglial dysfunction has been associated with several neurodegenerative diseases. CD33 and triggering receptor expressed on myeloid cells 2 (TREM2) are microglial receptors, variants of which affect Alzheimer’s disease (AD) risk, and therefore are …
Page 1 of 2