Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"microglia activation"”.
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Tau pathology, microglia activation, and network dysfunction in Alzheimer’s disease
Tau pathology and neuroinflammation are key etio-pathogenetic mediators of Alzheimer’s disease (AD). Network dysfunction has also been reported in AD and linked to cognitive impairment. However, it is unclear how tau pathology and neuroinflammation contribute to network dysfunction and cognitive …
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Molecular and Genetic Analysis of Parkin in Microglia Activation and Inflammation-Related Neurodegeneration
… can be significantly attenuated by impairment of microglial activation. In addition, previous studies from our lab reported that parkin-/- mice are more susceptible to inflammation-induced degeneration of nigral DA neurons. Therefore, inflammatory responses are a critical determinant of DA …
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Role of miR-19a-3p and miR-19b-3p in microglia activation and neuroinflammation
… to 60% of individuals with SCI. Following SCI, activation of microglia, the immune cells of the central nervous system, triggers neuroinflammation through the production of pro-inflammatory cytokines, contributing to neuropathic pain. The relationship between inflammation and pain is …
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A Role for Microglia Activation in Modulating Behavior in a Variable Stress Model for Depression
… both the peripheral and central immune systems. Microglia are the resident immune cells in the brain and changes in their morphology and state of activation in response to stress have been reported in a number of brain regions, however most studies examined only male subjects. In our studies we …
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Evaluating Microglia Dynamics in Blast and Impact-Induced Neurotrauma and Assessing the Role of Hemostatic Nanoparticles in Microglia Activation
… disparities has yet to be elucidated. Microglia dynamics play a key role in initiating the inflammatory response after injury, as microglia become activated by undergoing morphological changes that influence their function in the injured brain, and unique signaling pathways influence …
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Progress Towards Understanding Of Mechanisms Of Action Of Potent Multifunctional Disease Modifying Therapeutics For Parkinson's Disease & Investigating The Methamphetamine-Induced Striatal Microglia Activation.
… THE METHAMPHETAMINE-INDUCED </p> <p>STRIATAL MICROGLIA ACTIVATION</p> <p>by</p> <p>MRUDANG MANOJKUMAR SHAH</p> <p>December 2013</p> <p>Advisor: Dr. David Thomas</p> <p>Major: Pharmaceutical Sciences</p> <p>Degree: Doctor of Philosophy</p> <p>Methamphetamine is a highly abused, addictive and …
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Blood-Brain Barrier Permeability and Inflammation in Cerebral Small Vessel Disease
… role. We hypothesised that BBB permeability and microglia activation would be increased in SVD and explored the relationship between these processes and other imaging, cognitive and blood markers. Methods: A PET/MR system was used to acquire simultaneous dynamic contrast enhanced MRI with Patlak …
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Mechanisms of DNA double strand break-mediated neurotoxicity in neurodegenerative disease
… is significantly associated with immune activation in excitatory neurons. Spatial transcriptomics reveal that regions of CK-p25 brain tissue dense with DSB-bearing neurons harbor signatures of inflammatory microglia, which is ameliorated by NFκB knock down in neurons. Inhibition of NFκB …
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Neuroprotective and immunomodulatory properties of the new PPARγ agonist MDG548: an in vitro and in vivo study in PD models
… Parkinson’s disease (PD) neuropathology. Skewed microglia activation with pro-inflammatory prevailing over anti-inflammatory phenotypes may contribute to neurotoxicity via the production of cytokines and neurotoxic species. Therefore, microglia polarization has been proposed as a target for …
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The involvement of microglial activation in schizophrenia
Abnormal activation of brain microglial cells is widely implicated in the pathogenesis of schizophrenia. The disrupted balance of microglia phenotypes has been hypothesized to influence the clinical course of the disease and affect symptom severity. Previously, the pathophysiology of microglial …
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Unraveling the Effects of Nicotine-Derived Nitrosamine Ketone (NNK) on Healthy and Neurodegenerative Brain via Intravital Imaging and Multiscale Ex Vivo Imaging Approaches.
… of NNK on the blood brain barrier (BBB)or microglial immune cells of the brain as they relate to the vasculature. To investigate microglial and vascular responses to intranasal NNK in vivo, we combined the use of a transgenic mouse (CX3CR-1GFP) with intravital neuroimaging. We show that NNK …
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Inflammatory Mechanisms And Vulnerability For Major Depression: From Animal Models To Drug Treatment
… of relapse. Growing evidence suggest that the activation of the inflammatory/immune system contributes to the pathogenesis of depression. Indeed, depressed patients exhibit increased levels of inflammatory markers in both the periphery and the brain, and high comorbidity exists between major …
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Study of proteins after recovery from bacterial infection
… effect of Bacillus Calmette–Guérin (BCG) on the microglia of mice after recovery from infection is incompletely understood. Microglia cells of mice were collected from two groups, mice infected with BCG vs. control mice (BCG vs. control). The objective of this study was to compare the proteins …
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Traumatic Injury-Induced Cell Responses in Human Cortical Organoids
… to injury, the weight-drop impact results in microglia activation characterized by microglia ramification and expression of complement C3, CD68 and NF-kB. Surprisingly, this impedes rather than increases the proliferation of glial progenitors and astrocytes in 150 DIV cortical organoids. Our …
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Transient receptor potential vanilloid 1 exhibits neuroprotective effects in LPS-induced dopaminergic neuronal death in the suabstantia nigra in vivo.
… dopaminergic (DA) neuronal degeneration, microglia activation, inflammatory mediator expression and infiltration of peripheral immune cells in the SN. Additionally, we surveyed whether CAP would have ability to DA neuronal protection against LPS and how CAP regulates the inflamed …
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Glia-mediated mechanisms of HIV-1-gp120-induced Synaptic Degeneration
… synaptic degeneration. Because gp120 induced microglial activation, we further tested the hypothesis that microglia contribute to gp120-induced synaptic degeneration. We found that blockage of microglial activation abolished the synapse loss induced by gp120. Fractalkine (FKN; a.k.a.CX3C …
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Male-specific mechanisms in a murine model of nociplastic pain
… injury site in females and by reactive spinal microglia in males. Further investigation into the male-specific mechanisms underlying the nociplastic pain state revealed that activation of spinal microglia drives the postinjury vibration stimulation-triggered transition to a nociplastic pain …
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Male-specific mechanisms in a murine model of nociplastic pain
… injury site in females and by reactive spinal microglia in males. Further investigation into the male-specific mechanisms underlying the nociplastic pain state revealed that activation of spinal microglia drives the postinjury vibration stimulation-triggered transition to a nociplastic pain …
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Histone deacetylase inhibitors as novel neuroprotective agents in in vitro and in vivo models of Parkinson’s disease
… reduced the number of astrocytes and activated microglia suggesting a positive anti-inflammatory effect. The effects of the HDAC-Is were then assessed in the 6-hydroxydopamine- and LPS-lesioned mouse models of PD. Both SAHA and VPA protected dopaminergic neurones and decreased the number of …
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The Role of Tumor Necrosis Factor (TNF) in Microglial Activation and Progressive Degeneration of Dopaminergic Neurons
… deficits. Given the potential contribution of microglial activation to PD and the suggestion that anti-TNF therapies in the CNS may exert neuroprotective effects on vulnerable dopaminergic neuron populations, I also investigated the role of TNF in regulating microglia effector functions to …
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