Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"microfluidic screening"”.
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Generating artificial metalloenzymes containing new-to-nature organometallic cofactors via controlled ligand exchange and microfluidic screening technologies
… Further, the development of a high-throughput microfluidic screening platform is presented, with the aim to facilitate efficient directed evolution. The first chapter gives a theoretical description of the matter covered by this thesis and reviews the relevant fields, including considerations …
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A dielectrophoretic, microfluidic device for sorting lipid-producing organisms used as bio-oil sources
In this thesis, we present a microfluidic screening device for selecting high-lipid-content cells from a heterogeneous population. The device utilizes dielectrophoresis (DEP) to simultaneously sense and sort individual cells based on their internal lipid content. Microorganisms such as yeast, …
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The Identification and Development of Small Molecule Inhibitors of Amyloid β Aggregation
… therapeutics. A variety of issues with current screening methods, including lack of reproducibility, high reagent consumption and spectral interference from the test molecules, can limit efforts to identify new small molecule inhibitors. Furthermore, the lack of robust, time- and cost-efficient …
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High-throughput protein engineering tools for efficient exploration and quantitative mapping of protein fitness landscapes
… and isolation of desired phenotypes through screening or selection, has had a profound impact on society. It has led to the development of key pharmaceuticals, precision gene editing tools that target previously incurable diseases, and biocatalysts for the production of active pharmaceutical …