Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 67 for “"microfluidic channel"”.
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Dielectrophoretic manipulation of biological and non-biological analytes in a microfluidic channel
… and high-gradient strong ac electric field. A microfluidic device equipped with dielectrophoretic gates arranged perpendicular to the flow was designed and fabricated at Sandia National Laboratories. Experiments were conducted on flowing suspensions over a broad range of flow and electric field …
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Measurement of flow in a microfluidic channel in response to application of voltage
… the flow of Electrorheological fluid in a microfluidic channel in response to a gradient in an electric field: MATLAB simulation and microscopy experiments. Electrorheological fluid, which is composed of particles suspended in a liquid, has the property of changing its viscosity under the …
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Integration of photonic and passive microfluidic devices into lab-on-chip with femtosecond laser materials processing
… tilted 3D geometry with one arm crossing a microfluidic channel and enables spatially resolved sensing of changes in the refractive index of the content inside the channel with a limit of detection as low as 1x10 4 RIU. Another major technique in femtosecond laser materials processing is …
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Embedded Passivated-electrode Insulator-based Dielectrophoresis
… field strength and capture efficiency within the microfluidic channel while alleviating direct contact between the electrode and the fluid. The EπDEP chip contains embedded electrodes within the microfluidic channel covered by a thin passivation layer of only 4 μm. The channel was designed with …
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Micro-impedance cytometry
… detection and a wide range of impedance-based microfluidic devices have been reported. Despite the number of contributions and the achievements of this field, micro-impedance cytometry still suffers from a lack of sensitivity and specificity compared to traditional flow cytometry, which limits …
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On-chip multi-dimensional biomolecule separation using multi-layer microfabricated valves
… multi-dimensional biomolecule separation in a microfluidic channel. The new methods couple isoelectric focusing (IEF) with high ionic strength capillary electrophoresis (CE) by active micro valve control in a microchip. Several experiments demonstrating independent 2D separation were performed, …
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Development of adhesive bonding and functional testing systems for in-process inspection of hot embossed microfluidic devices
Microfluidics has emerged as an increasingly popular field with a wide-variety of applications such as medical diagnostics, drug development, and DNA analysis. The transition of microfluidic devices from research to industry has stimulated interest in producing them at low costs and high volumes. …
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Preliminary investigation on optical cavity-based biosensor using double-sided tape.
… rates of diseases like cancer. Biosensors and microfluidics can aid in making detection more affordable and accessible. Our team has developed a foundational optical cavity-based biosensor capable of biomarker detection using low-cost fabrication methods, components, and a differential …
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Biocompatible silicon nitride thin films for self-rolled-up microtube technologies: guiding neurons
… easily fabricated and can be integrated into a microfluidic channel (or become the channel itself) which can be easily integrated into an intravenous or catheter tube for diagnostics. Taking advantage of SiNx’s insulting properties allows conductance-based biosensors to be integrated into the …
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Thermoplastic bonding of microfluidic substrates
The assembly of microfluidic components for lab on a chip (LOC) applications that are manufactured from commodity thermoplastics is challenging. A survey of plastic welding techniques validates that contour transmission laser welding is the most viable and commercially demonstrated option for …
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A malaria diagnostic system based on electric impedance spectroscopy
… electric impedance spectroscopy (EIS) on a microfluidic device as a means of malaria diagnosis. This work introduces a microfabricated probe with microfluidic channel, and a high speed impedance analyzer circuit board. Combination of microfluidic device and circuit board resulted in a …
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Real time, integrated, paper based temperature sensor for lab on a chip device
… to sense and control the temperature in microfluidic systems. The primary challenge has been the twin problem of integration and accuracy using minimal equipment while keeping it simple. In this study, an equipment free fabrication of the temperature sensor using filter paper impregnated …
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Characterization of Mixing in a T-style Microfluidic Chip
… is to characterize the mixing that occurs in a microfluidic chip. To characterize the mixing, the minimum length to complete mixing and evolution of mixing will be investigated. There are two types of mixing that occur within a microfluidic channel, diffusion and advection. In the beginning of …
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Suspended microchannel resonators for ultralow volume universal detection
… unique scaling properties of the suspended microchannel resonator (SMR) are exploited to show universal detection in a 10 pL analysis volume with a density detection limit of ~1 ([mu]g/cm³ (10 Hz bandwidth) and a linear dynamic range of six decades. Analytes with low UV extinction coefficients …
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Suspended microchannel resonators for biomolecular detection
… in nanoliter sized samples. Integrating microfluidic detection and sample-preparation can greatly leverage experimental efforts in systems biology and pharmaceutical research by increasing analysis throughput while dramatically reducing reagent cost. Microfabricated resonant mass sensors …
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Basic Study Of Micromachined Dep (dielectrophoretic) Manipulator
… manipulator, the fabrication and packaging of microfluidic structure with the microelectrode is crucial for reliable analysis. A combination of SU-8 photoresist and polydimethylsiloxane polymer was used for this purpose. Besides, the DEP manipulator, preliminary study on a Coulter counter was …
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A multiplex platform based on cellular barcoding for measuring single cell drug susceptibility
… viability or growth rate. Previously, the serial microfluidic mass sensor arrays have been used to measure single-cell mass accumulation rates over ~20 minute intervals to assess drug susceptibility. Here, we present a multiplexing platform that allows evaluation of multiple drug response …
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Design and fabrication of a microneedle for the implantation of floating microstimulators
… microstimulators pumped out by fluid through a microfluidic channel
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Self-rolled-up microtube technology for cellular outgrowth guidance and monitoring
… easily fabricated and can be integrated into a microfluidic channel (or become the channel itself) which can be easily integrated into an intravenous or catheter tube for diagnostics. In this dissertation, the advantages of silicon nitride (SiNx) based s-RuMs are investigated and outlined, …
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Sensing Molecular Adsorption Through Interfacial Electron Scattering in Atom -Scale Junctions
… gap was lithographically defined, and a microfluidic channel was aligned over the inter-electrode gap. The inter-electrode gap was reduced with electrodeposition, which was terminated at an atom-scale junction by setting a comparator to trigger a relay at a current corresponding to a …
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